Solid-phase rearrangement of aminals of 5-halofurfurals to 5-N,N-dialkylamino-furfurlyidene-N,N-dialkylimmonium salts

Novikov, V. N.

doi:10.1007/bf00506358

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2023

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“…Examples include 5-fluorouracil and 5-chlorouracil, which were among the first pharmacologically active derivatives that have been generated. 4 5 During the last several decades, modifications have been made to the C5 position of the uracil structure to enhance its pharmacological and pharmacokinetic properties. These modifications have led to derivatives with increased bioactivity and lower toxicity.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Synthesis of 5-(Hetero)aryl Uracil Derivatives

Wang

Liu

et al. 2023

Synlett

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C5-Aryl/heteroaryl uracil-based compounds have attracted continuous interest because of their wide biological potential. In this review we outlined the primary synthetic methods used to prepare designated uracils, all of which were often combined to synthesize target compounds with potential biological activities. Significance of each approach and its limitation were also summarized. 1 Introduction 2 Coupling of pre-functionalized uracils with (hetero)aryl reagents 3 Coupling of functionalized uracils with unactivated aromatic (hetero)cycles 4 Coupling of unactivated uracil/uridine with functionalized aromatic (hetero)cycles 5 Direct coupling of unactivated uracils with unactivated aromatic and heterocycles 6 Summary and Prospects

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Section: Introductionmentioning

confidence: 99%