Solid Phase Preparation of 1,3‐Disubstituted Indazole derivatives

Abstract

The immobilization and reactions of indazol-3-carboxylic acid on the solid phase is described. These reactions are of importance since many biologically active compounds contain an indazole core. Here, indazole 3-carboxylic acid was efficiently anchored onto the solid phase via a protecting group strategy. The indazolic NH was then derivatized to sulfonamides, ureas, amides, carbamates, and amines. Depending on compound class yield and purity varied but was generally high.