Solid-phase photosensitizers based on fullerene C_60 for photodynamic inactivation of viruses in biological liquids

Белоусова, И. М.; Danilov, O. B.; Murav'eva, T. D.; Kiselyakov, I. M.; Rylkov, V. V.; Kris’ko, T. K.; Киселев, О. И.; Zarubaev, Vladimir V.; Сироткин, А. К.; Piotrovskii, L. B.

doi:10.1364/jot.76.000243

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…However, they retained some ability to inactivate viruses under illumination by visible light. [19] Designed in our work heterogeneous sensitizers possess high activity in virus photoinactivation. [42,43] Samples S10-p-AlPc3, S25-p-AlPc3 and S75-p-AlPc3 (loading of the support by the AlPc3 -5 µmol•g -1 ) were used in these studies.…”

Section: Photodynamic Inactivation Of Virusesmentioning

confidence: 99%

“…Thus, for photodynamic inactivation of viruses, a suspension of fullerene C 60 has been suggested. [19] Monomeric fullerenes are known to efficiently produce singlet oxygen upon irradiation in organic media showing strong potential for photodynamic action in biological systems. Contrariwise, suspensions of aggregated fullerenes in water have very low yield of singlet oxygen.…”

Section: Photodynamic Inactivation Of Virusesmentioning

confidence: 99%

“…Nevertheless, during the past two decades interest to photodynamic inactivation of microorganisms in water and biological fluids, including use of heterogeneous singlet oxygen sensitizers, was renewed mostly due to emergence of antibiotic resistant pathogens. [13] Thus, recently the photobactericidal activities of some heterogeneous systems, such as bound to silica gel and cellulose porphines, [14,15] porphyrin and phthalocyanine photosensitizers incorporated into chitosan, [16] tetracationic porphyrin encapsulated within silica microparticles, [17] polyazaheterocyclic Ru II coordination compound adsorbed at porous silicone, [18] a suspension of fullerene C 60 , [19] were tested.…”

Section: Introductionmentioning

confidence: 99%

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Heterogenized metallophthalocyanines for photodynamic microorganism inactivation: an overview of our experience

Kuznetsova¹,

Kaliya²

2015

MHC

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Heterogeneous systems synthesized by grafting of phthalocyanines to aminopropyl silica gel can exhibit high photobactericidal and photovirucidal activity. In this review, recent works of Russian group in the field are summarized. Ways to achieve low aggregation degree and high ability in singlet oxygen generation for immobilized phthalocyanine as well as effects of charge of attached phthalocyanine, support pore size, length of spacer between dye and silica upon efficacy of heterogeneous sensitizers in photodynamic microorganism inactivation are considered.

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Section: Photodynamic Inactivation Of Virusesmentioning

confidence: 99%

Section: Photodynamic Inactivation Of Virusesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Heterogenized metallophthalocyanines for photodynamic microorganism inactivation: an overview of our experience

Kuznetsova¹,

Kaliya²

2015

MHC

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“…Ничтожно малая растворимость фуллерена в водных системах является, с одной стороны, благоприятным фактором, облегчающим его удаление после фотодинамического воздействия на биологическую систему, а с другой, фактором, снижающим эффективность фотосенсибилизации (ФС). Поэтому много усилий предпринималось для создания и исследования устойчивых золей на водной основе, сохраняющих ФС-свойства [9]. Для этого применялись как поверхностно-активные вещества [10], так и водно-мицеллярные коллоиды [11].…”

Section: Introductionunclassified

Спектральное Исследование Фотодинамических Процессов В Системе C-=sub=-60-=/SUB=--(н-метилпирролидон)-кислород

Kislyakov

Белоусова²,

Киселев³

et al. 2021

Оптика И Спектроскопия

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The processes of photoexcitation and energy transfer in an air-saturated solution of fullerene C60 in n-methylpyrrolidone are studied. With femtosecond laser pumping at a wavelength л(p) = 520 nm, transient absorption spectra were obtained in the range 470-750 nm. Broadband absorption is observed at л > 650 nm as a result of aggregation of fullerene molecules, characterized by a short decay time of the picosecond scale. The analysis of the time dependencies indicates the presence of several processes. Within the proposed interpretation, we state a remarkable reduction in the time of singlet-triplet intersystem crossing with an increase of nanocluster size while the rapid quenching of the singlet state varies only slightly. The quantum yield of the triplet state can therefore increase, reaching 0.14. The phosphorescence spectra of singlet oxygen with a maximum at л = 1276 nm were measured with LED excitation at various wavelengths in the range 370-625 nm. The lifetime and quenching rate constant of singlet oxygen in n-methylpyrrolidone are determined. The combined quantum yield of triplet fullerene and singlet oxygen in n-methylpyrrolidone is estimated as 0.74. The efficiency spectra of the singlet oxygen photosensibilization in the C60-(n-methylpyrrolidone)-oxygen system are obtained, indicating the increasing role of large nanoclusters in this process during aging of the solution.

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“…Various photosensitizers have been shown to exhibit antimicrobial activity when incorporated into polyurethane coating systems under specific conditions [25][26][27]. Similarly, antiviral systems have successfully been developed with the incorporation of fullerene as a solid-phase photosensitizer into biological fluid [28]. Recently, fullerenes modified with intercage constituents have displayed a remarkable ability to produce singlet oxygen as well as antimicrobial activity in polymeric adhesive films [29].…”

Section: Introductionmentioning

confidence: 99%

Self-Cleaning Photocatalytic Polyurethane Coatings Containing Modified C60 Fullerene Additives

et al. 2014

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Surfaces are often coated with paint for improved aesthetics and protection; however, additional functionalities that impart continuous self-decontaminating and self-cleaning properties would be extremely advantageous. In this report, photochemical additives based on C 60 fullerene were incorporated into polyurethane coatings to investigate their coating compatibility and ability to impart chemical decontaminating capability to the coating surface. C 60 exhibits unique photophysical properties, including the capability to generate singlet oxygen upon exposure to visible light; however, C 60 fullerene exhibits poor solubility in solvents commonly employed in coating applications. A modified C 60 containing a hydrophilic moiety was synthesized to improve polyurethane compatibility and facilitate segregation to the polymer-air interface. Bulk properties of the polyurethane films were analyzed to investigate additive-coating compatibility. Coatings containing photoactive additives were subjected to self-decontamination challenges against representative chemical contaminants and the effects of additive loading concentration, light exposure, and time on chemical decontamination are reported. Covalent attachment of an ethylene glycol tail to C 60 improved its solubility and dispersion in a hydrophobic polyurethane matrix. Decomposition products resulting from oxidation were observed in addition to a direct correlation between additive loading concentration and decomposition of surface-residing contaminants. The degradation pathways deduced from contaminant challenge byproduct analyses are detailed.

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Solid-phase photosensitizers based on fullerene C_60 for photodynamic inactivation of viruses in biological liquids

Cited by 7 publications

References 21 publications

Heterogenized metallophthalocyanines for photodynamic microorganism inactivation: an overview of our experience

Heterogenized metallophthalocyanines for photodynamic microorganism inactivation: an overview of our experience

Спектральное Исследование Фотодинамических Процессов В Системе C-=sub=-60-=/SUB=--(н-метилпирролидон)-кислород

Self-Cleaning Photocatalytic Polyurethane Coatings Containing Modified C60 Fullerene Additives

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