Solid phase “on-situ” quadraplex isotope dimethyl labeling for the analysis of biogenic amines in beers by liquid chromatography-high resolution mass spectrometry

Magnetic Molecularly Imprinted Nano-Conjugates for Effective Extraction of Food Components—A Model Study of Tyramine Determination in Craft Beers

“…The tyramine concentrations in all tested beers except the sample of S6 were very similar to the results presented in other studies [35,36]. For example, Miao et al [22] found the tyramine levels in six various beers between 0.138 and 2.912 mg L −1 ; Tang et al [17] found tyramine in eighteen beer samples at levels between 2.90 and 7.15 mg L −1 ; Almeida et al [20] determined tyramine in beers in ranges between 0.394 and 5.916 mg L −1 ; Romero et al [38] found tyramine concentration in Spanish beer samples between 0.26 and 31.69 mg L −1 ; and Słomkowska and Ambroziak [31] found tyramine levels between 0.48 and 4.00 mg L −1 in Polish (not craft) beers. The high tyramine level in the sample S6 could be explained by the composition of the beer, which consisted of chocolate wheat and coffee.…”

“…Most of the methods required sample derivatization with isobutyl chloroformate, dansyl chloride, o-phthaldialdehyde, diethyl ethoxymethylenemalonate, or 2,6-dimethyl-4quinolinecarboxylic acid N-hydroxysuccinimide ester, which was not needed in the proposed one. The lowest concentration on the calibration curve of our method (0.15 mg L −1 ) was higher than in the methods developed by Miao et al [22] (0.001 mg L −1 ), Almeida et al [20] (0.01 mg L −1 ), Daniel et al [21] (0.05 mg L −1 ), and He et al [18] (0.14 mg L −1 ). The method precision (1.7-4.9%) was comparable to other methods (0.72-7.4%), except for the method developed by Angulo et al [35], in which the precision was 11.5%.…”

“…The derivatization step was not included only in a few tyramine quantification methods in beverages [19]. Application of mass spectrometry (MS) detectors with capillary electrophoresis as well as liquid (LC) or gas chromatography (GC) is an alternative for tyramine analysis [20][21][22]. However, to obtain optimal determination conditions, the pretreatment clean-up is necessary.…”

“…Here, liquid-liquid or solid phase extractions (SPE) are versatile tools. Miao et al [22] described solid phase "on-situ" quadraplex isotope dimethyl labeling for the analysis of biogenic amines in beers by LC-high resolution MS involving magnetic material. It allowed for the operational simplicity and rapidity of separation of magnetite in the external magnetic field as well as high extraction efficiency, the ability to extract analytes from large volume samples, and cost-effectiveness derived from the dispersive solid phase extraction (d-SPE) technique.…”

The Measurement of Hazardous Biogenic Amines in Non-Alcoholic Beers: Efficient and Applicable Miniaturized Electro-Membrane Extraction Joined to Gas Chromatography-Mass Spectrometry

“…A high intake of putrescine may increases the risk of colorectal adenocarcinoma [ 34 ]. Tyramine is formed in food products by the decarboxylation of tyrosine and triggers severe migraines in individuals [ 35 ]. The concentration ranges announced for tyramine, histamine, cadaverine and putrescine in this experiment were 0.86–2.33 µg g −1 , 0.39–0.76 µg g −1 , 0.52–0.93 µg g −1 and 0.89–3.87 µg g −1 , respectively.…”