Solid-Phase Fluorimetric Determination of Some Nonsteroidal Anti-Inflammatory Drugs in Medicines with the Aid of a Smartphone

Амелин, В. Г.; Shogah, Z. A. Ch.; Большаков, Д. С.

doi:10.1007/s11094-021-02523-9

Cited by 5 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, it has become necessary to develop simple and sensitive methods to determine its presence in pharmaceutical formulations and biological matrices. Measuring MFA content in different formulations and matrices was reported using chromatographic [8][9][10][11][12][13][14][15], electrochemical [16,17], and spectroscopic [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] methods.…”

Section: Introductionmentioning

confidence: 99%

Development of an eco‐friendly fluorescent probe for mefenamic acid sensing in pharmaceuticals and biofluids

El Azab,

Alqirsh,

Magdy

et al. 2024

Luminescence

View full text Add to dashboard Cite

Mefenamic acid, renowned for its analgesic properties, stands as a reliable choice for alleviating mild to moderate pain. However, its versatility extends beyond pain relief, with ongoing research unveiling its promising therapeutic potential across diverse domains. A straightforward, environmentally friendly, and sensitive spectrofluorometric technique has been developed for the precise quantification of the analgesic medication, mefenamic acid. This method relies on the immediate reduction of fluorescence emitted by a probe upon interaction with varying concentrations of the drug. The fluorescent probe utilized, N‐phenyl‐1‐naphthylamine (NPNA), was synthesized in a single step, and the fluorescence intensities were measured at 480 nm using synchronous fluorescence spectroscopy with a wavelength difference of 200 nm. Temperature variations and lifetime studies indicated that the quenching process was static. The calibration curve exhibited linearity within the concentration range of 0.50–9.00 μg/mL, with a detection limit of 60.00 ng/mL. Various experimental parameters affecting the quenching process were meticulously examined and optimized. The proposed technique was successfully applied to determine mefenamic acid in pharmaceutical formulations, plasma, and urine, yielding excellent recoveries ranging from 98% to 100.5%. The greenness of the developed method was evaluated using three metrics: the Analytical Eco‐scale, AGREE, and the Green Analytical Procedure Index.

show abstract