Solid-phase extraction or liquid chromatography coupled on-line with gas chromatography in the analysis of biological samples

Quantification of antihistamine acrivastine in plasma by solid-phase extraction and high-performance liquid chromatography

“…Solid-phase extraction has been exten- sively employed in the pharmaceutical and biomedical analysis, due largely to significant advantages and improvements in automation, reproducibility and high-throughput capability [15,16]. For acrivastine, however, previous extraction methods were mainly complex and time-consuming, which commonly involved several rounds of extraction and derivatization [11,12].…”

SPE–GC–MS for the sampling and determination of unmetabolized styrene in urine☆

“…As regards the possible eluent solvents, both dichloromethane and ethyl acetate are suitable when gas chromatography is to be used [30,31].…”

A new strategy for ionization enhancement by derivatization for mass spectrometry

“…To overcome these drawbacks, several means to remove other matrix components and concentrate the sample have been proposed. One of them, solid-phase extraction (SPE), is commonly used for the removal of proteins and other matrix components from biological samples [18][19][20]. If we want to concentrate a sample to measure analytes present at low concentrations, the sample should have a large volume.…”