Solid phase extraction of pesticides from environmental waters using an MSU-1 mesoporous material and determination by UPLC-MS/MS

Kharbouche, Leila; García, Miguel de Cara; Lozano, Ana; Hamaizi, Hadj; Galera, M. Martı́nez

doi:10.1016/j.talanta.2019.02.092

Cited by 39 publications

(13 citation statements)

References 42 publications

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“…Solid-phase extraction (SPE) is probably the most widely used sample preparation technique in LC-MS analysis of compounds of varying chemistries and diverse matrices including samples from environmental waters (Kharbouche et al, 2019;Sabik et al 2000). It is not always necessary to evaporate the solvent to achieve the desired enrichment factor of analytes (Tankiewicz et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

Targeted and non-targeted analysis of organic compounds of moderate polarity in water using liquid chromatography-time of flight mass spectrometry in all ion mode with particular reference to analysis of pesticides

Marwah

Zimba

et al. 2020

JANS

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We have developed a novel yet efficient method for the multi residue analysis of organic compounds of diverse polarities in water using Liquid Chromatography-Time of Flight mass spectrometry (LC-MS-TOF) equipped with a jet stream Electrospray ionization (ESI) source. Use of three different fragmentor voltages (low, medium and high) enabled the qualitative and quantitative analysis of a diverse range of targeted organic compounds in environmental waters. No prior optimization of compounds being quantified was required, the limiting factors were ionization behaviour of compounds under conditions of ESI and good chromatography. Same data file could be subjected to repeated post-run data analysis to figure out the presence of non-targeted compounds, including designer drugs if any. The technique has been illustrated with reference to a group of pesticides having diverse chromatographic and ionization behaviours. The optimized Solid Phase Extraction (SPE) followed by method validation yielded a robust yet simple quantitative method for a group of fourteen pesticides. We were able to achieve quantitation at 10 ng/L or lower depending upon ionization behaviour of substrates against the usual regulatory requirement of 1000 ng/L. The method was used for targeted and non-targeted detection of pesticides in Nueces estuary waters, TX, USA, and several untargeted pesticides, pharmaceuticals and personal care products were identified.

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Section: Resultsmentioning

confidence: 99%

Targeted and non-targeted analysis of organic compounds of moderate polarity in water using liquid chromatography-time of flight mass spectrometry in all ion mode with particular reference to analysis of pesticides

Marwah

Zimba

et al. 2020

JANS

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“…UPLC-MS/MS has offered many advances in analytical techniques and is commonly used in environmental, bioanalytical, and pharmaceutical research (Beltifa et al, 2019;Bollen et al, 2019;Kharbouche et al, 2019;Mei et al, 2019;Xu et al, 2019;Zheng et al, 2019;Xie et al, 2020b;King et al, 2020;Wang et al, 2020). Thus, we developed a highly rugged, fast, and selective UPLC-MS/MS method to determine the concentrations of acteoside, angoroside C, harpagoside, and cinnamic acid in rat plasma.…”

Section: Introductionmentioning

confidence: 99%

Determination and Pharmacokinetic Profiles of Four Active Components From Scrophularia ningpoensis Hemsl. in Rats

et al. 2021

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Acteoside, angoroside C, harpagoside, and cinnamic acid, which are the main bioactive ingredients of Scrophularia ningpoensis Hemsl., have wide clinical use with various biological effects. A new and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established with taxifolin as the internal standard (IS) in this study and was successfully used to study the pharmacokinetic profiles of four active components from S. ningpoensis Hemsl. in rats after sublingual intravenous administration. After protein precipitation with acetonitrile, the mobile phase (consisting of acetonitrile and 0.1% formic acid) was used to separate the analytes on an Acquity UPLC BEH C18 chromatography column (2.1 × 50 mm, 1.7 μm) under gradient elution. The precursor-to-product ion transitions of 623.4 → 161.3 m/z for acteoside, 783.5 → 175.0 m/z for angoroside C, 493.3 → 345.2 m/z for harpagoside and 147.2 → 103.4 m/z for cinnamic acid were monitored by mass spectrometry with negative electrospray ionization in the multiple reaction monitoring (MRM) mode. The concentration range of 10–1,000 ng/ml could be detected by this method with a lower limit of quantification (LLOQ) of 10 ng/ml for each analyte. The intra- and inter-day precision (RSD%) of the method ranged from 2.6 to 9.9% and 2.7–11.5%, respectively. Meanwhile, the accuracy (RE%) was −9.6–10.7% in this developed method. The mean recoveries of four active components from S. ningpoensis Hemsl. were more than 76.7% with negligible matrix effects. The four active components from S. ningpoensis Hemsl. were stable under multiple storage and process conditions. A new, sensitive and simple analytical method had been established and was successfully applied to the pharmacokinetic profiles of four active components from S. ningpoensis Hemsl. in rats after sublingual intravenous administration.

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“…In this context, ordered mesoporous silicas have gained increasing interest due to their physical properties, which have been described elsewhere [36]. These compounds have been used as such or derivatized to preconcentrate different organic contaminants in liquid samples [34,37–44].…”

Section: Introductionmentioning

confidence: 99%

Determination of personal care products in water using UHPLC–MS after solid phase extraction with mesoporous silica‐based MCM‐41 functionalized with cyanopropyl groups

Kharbouche

García

Lozano

et al. 2020

J of Separation Science

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A silica-based MCM-41 mesoporous material functionalized with cyanopropyl groups has been synthesized by cocondensation, characterized and applied to preconcentrate six parabens and three UV filters in river and swimming-pool waters. The analytes were quantified by ultra-high performance liquid chromatography-tandem mass spectrometry, according to the Directive 96/23/EC. Even though matrix effect was negligible, quantification in river water samples with the standard addition approach improved the recoveries obtained using solvent-based and even with matrixmatched calibration. The method quantification limits in river water samples were 0.05 ng/mL for 2,4-dihydroxybenzophenone and 0.01 ng/mL for the rest. Recoveries, evaluated for a concentration level of 0.5 ng/L, were in the range 93.5-107.6% for parabens and in the range 64.2-85.8% for UV filters, with relative standard deviations intraday ≤10.2 and 10.8%, respectively. This parameter, evaluated for a concentration level of 0.1 ng/L, ranged between 98.3 and 110.4% for parabens and between 61.9 and 89.9% for UV filters, with relative standard deviation intraday ≤15.3 and 15.5%, respectively. The two UV filters with lower recoveries were the most affected by the addition of sodium chloride. River and swimming pool waters were analyzed and all the personal care products were found in the swimming pool water, whereas only methylparaben was detected in the river water. K E Y W O R D Sfunctionalized MCM-

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Solid phase extraction of pesticides from environmental waters using an MSU-1 mesoporous material and determination by UPLC-MS/MS

Cited by 39 publications

References 42 publications

Targeted and non-targeted analysis of organic compounds of moderate polarity in water using liquid chromatography-time of flight mass spectrometry in all ion mode with particular reference to analysis of pesticides

Targeted and non-targeted analysis of organic compounds of moderate polarity in water using liquid chromatography-time of flight mass spectrometry in all ion mode with particular reference to analysis of pesticides

Determination and Pharmacokinetic Profiles of Four Active Components From Scrophularia ningpoensis Hemsl. in Rats

Determination of personal care products in water using UHPLC–MS after solid phase extraction with mesoporous silica‐based MCM‐41 functionalized with cyanopropyl groups

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