Solid phase extraction of antidepressant drugs amitriptyline and nortriptyline from plasma samples using core-shell nanoparticles of the type Fe3O4@ZrO2@N- cetylpyridinium, and their subsequent determination by HPLC with UV detection

Zare, Fahimeh; Ghaedi, Mehrorang; Daneshfar, Ali

doi:10.1007/s00604-015-1499-3

Cited by 42 publications

(10 citation statements)

References 48 publications

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“…The results showed that the extraction efficiency decreased with the increase in ionic strength. This may be attributed to the formation of physical barrier across samples and adsorbent, which prevents the mass transfer of analytes into the surface of the adsorbent . Therefore, no salt was added.…”

Section: Resultsmentioning

confidence: 99%

Ultrasound‐assisted dispersive micro‐solid‐phase extraction using hydrophobic thiolated ionic liquids immobilized on gold nanoparticles for the preconcentration and determination of amino acids in human plasma samples

Zare

Jannesar

Purkait

et al. 2018

Separation Science Plus

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We describe the pre‐column derivatization of 19 amino acids with o‐phthalaldehyde/2‐mercaptopropionic acid. The derivatives were extracted using an ultrasound‐assisted dispersive micro‐solid‐phase extraction based on hydrophobic thiolated ionic liquids immobilized on gold nanoparticles. For this purpose, 10 mg of adsorbent was added to 10 mL of aqueous sample in the absence of any electrolyte and was inserted in ultrasound bath, which led to the efficient dispersion of adsorbent. The correlation between the extraction efficiency and parameters were optimized using experimental design and response surface methodology. The effects of alkyl‐chain length and anion of hydrophobic thiolated ionic liquids on the surface water wettability of gold nanoparticles were measured. Also, NMR spectroscopy and BET analysis were performed to recognize the formation of thiolated ionic liquids. Transmission electron microscopy, FTIR spectroscopy and X‐ray diffraction were conducted to characterize the gold nanoparticles. The suggested method shows a linear range (0.5–500 μmol L−1) under the optimized conditions with limits of detection in the range of 0.11–0.98 μmol L−1 for analytes. The validated method was successfully used for the quantification of nineteen amino acid derivatives with relative recoveries in the acceptable range of 81.1–104.4% and relative standard deviation less than 4.2%.

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Section: Resultsmentioning

confidence: 99%

Ultrasound‐assisted dispersive micro‐solid‐phase extraction using hydrophobic thiolated ionic liquids immobilized on gold nanoparticles for the preconcentration and determination of amino acids in human plasma samples

Zare

Jannesar

Purkait

et al. 2018

Separation Science Plus

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“…It was observed that the peak area of the target analytes increases with ultrasonic time up to 6.8 min and decreases thereafter. Moreover, it was revealed that the transfer of analytes from the aqueous phase to the extraction solvent was fast due to the considerably large surface area between the aqueous phase and the extraction solvent . This result is the most important advantage of applying the ultrasonic waves in DLLME‐SFO procedure.…”

Section: Resultsmentioning

confidence: 99%

Dispersive liquid‐liquid microextraction based on the solidification of floating organic droplets for preconcentration of amino acids in human plasma samples

Zare

Jannesar

Ghaedi

et al. 2018

Separation Science Plus

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In this research, dispersive liquid‐liquid microextraction was established based on the solidification of floating organic droplets. This simple, fast, and eco‐friendly sample extraction method allows preconcentration and identification of amino acids in plasma samples through the use of high‐performance liquid chromatography with fluorescence detection. By application of central composite design, the main factors in the microextraction procedure were optimized. The optimal experimental parameters were: 330 μL of 1‐dodecanol as an extraction solvent, 340 μL of acetone as disperser solvent, 140 μL of methanol as diluent at 6.8 min of ultrasonic time, and finally cooling in an ice bath for 3 min. Under these optimal conditions, good responses for 19 amino acids were obtained in the concentration ranges of 0.5–400 μmol L−1, with coefficients of determination higher than 0.9993. Limits of detection were based on a signal‐to‐noise ratio of 3, and ranged from 0.09 to 0.85 μmol L−1. In conclusion, the results demonstrate that this method was successfully applied to determine the amino acids in plasma samples. The relative recoveries of the 19 amino acids ranged from 81 to 103%, with relative standard deviations ranging from 1 to 4%.

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“…Overall, this MSPE method exhibited selective and efficient extraction of these tricyclic antidepressants, even more considering their stability over a 3-12 pH range and that just 5 mg of sorbent is required to achieve these good recoveries [32].…”

Section: Nanoshellsmentioning

confidence: 98%

“…For antidepressants extraction, the core-shell nanoparticles of the type Fe 3 O 4 MNPs@ZrO 2 modified at their surface by N-cetylpyridinium have been used for the quantitative extraction by MSPE of amitriptyline and nortriptyline from plasma [32]. The study showed 89 to 105% extraction relative recoveries and detection limits of 0.04 and 0.08 ng mL -1 for amitriptyline and nortriptyline, respectively, due to the enhancement of in adsorption mechanism through chain-chain interactions or hydrophobic, hydrogen bonding or electrostatic interaction with the polar groups, which are more selective and efficient than Fe 3 O 4 @ZrO 2 or bare Fe 3 O 4 NPs.…”

Section: Nanoshellsmentioning

confidence: 99%

“…MNPs has also been ensembled with other nanoparticles to increase the antidepressants extraction ability. In one such case, Fe 3 O 4 MNPs had been used with zirconium dioxide (ZrO 2 ) NPs for the simultaneous extraction of nortriptyline and amitriptyline from human plasma[32]. More specifically, a hydrophobic layer of N-cetylpyridinium surfactant was adsorbed onto the surface of the Fe 3 O 4 MNPs@ZrO 2 composites driven by both electrostatic attraction and strong hydrophobic interactions, thus enhancing the extraction of these basic compounds (from 89 to 105%), as this outer surface provides different mechanisms (i.e.…”

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confidence: 99%

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Strategies for antidepressants extraction from biological specimens using nanomaterials for analytical purposes: A review

Murtada

Andrés

Zougagh

et al. 2019

Microchemical Journal

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Solid phase extraction of antidepressant drugs amitriptyline and nortriptyline from plasma samples using core-shell nanoparticles of the type Fe3O4@ZrO2@N- cetylpyridinium, and their subsequent determination by HPLC with UV detection

Cited by 42 publications

References 48 publications

Ultrasound‐assisted dispersive micro‐solid‐phase extraction using hydrophobic thiolated ionic liquids immobilized on gold nanoparticles for the preconcentration and determination of amino acids in human plasma samples

Ultrasound‐assisted dispersive micro‐solid‐phase extraction using hydrophobic thiolated ionic liquids immobilized on gold nanoparticles for the preconcentration and determination of amino acids in human plasma samples

Dispersive liquid‐liquid microextraction based on the solidification of floating organic droplets for preconcentration of amino acids in human plasma samples

Strategies for antidepressants extraction from biological specimens using nanomaterials for analytical purposes: A review

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