Solid phase extraction and HPLC determination of veterinary pharmaceuticals in wastewater

Babić, Sandra; Ašperger, Danijela; Mutavdžić, Dragana; Horvat, Alka J.M.; Kaštelan‐Macan, Marija

doi:10.1016/j.talanta.2006.07.003

Cited by 123 publications

(64 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…LC-MS or LC-MS/MS was used in majority of studies. One study referred UV detection of antibiotics in wastewaters [12]. However, in some studies, UV detection was used during the development step; MS detection was employed for further quantification and confirmation of analytes.…”

Section: Screening Methodsmentioning

confidence: 99%

“…In attempt to improve the ionization of analytes and sensitivity of MS detection in the analysis of antibiotics, modification of mobile phase was usually performed and has been accomplished with volatile additives such as formic acid (FAc), acetic acid (AcAc), and ammonium acetate (AmAc) at different concentration. Babić et al [12] used oxalic acid and ACN in mobile phase for the determination of antibiotics in wastewaters. This was possible due to UV detection and thus nonvolatile modificator could be used.…”

Section: Chromatographymentioning

confidence: 99%

“…The sensitivity of method also depends on the purpose of the method and its application on real samples. Babić et al [12] achieved LOD and LOQ suitable for the detection of analytes in wastewaters, where the concentrations were higher than in surface waters.…”

Section: Sulfonamide Antibiotics and Trimethoprimmentioning

confidence: 99%

“…The persistence depends on their photostability, binding and adsorption capacity, degradation rate and leaching into the water. Strongly sorbing pharmaceuticals tend to accumulate in soils or sediment (TCs, FQs) and by contrast, highly mobile pharmaceuticals (SAs) have a potential to resist degradation and tend to leach into the groundwater and to be transported with the groundwater, drainage water and surface water run-off to surface waters [12]. The sorptive exchange of chemicals between a water phase and a solid phase is represented by the sorption coefficient K d,solid , which is defined as the ratio between the concentration of the compound in the sorbent and in the water at the equilibrium [13].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

298

170

View full text Add to dashboard Cite

a b s t r a c tThe widespread occurrence of antibiotics as contaminants in the aquatic environment has increased attention in the last years. The concern over the release of antibiotics into the environment is related primarily to the potential for the development of antimicrobial resistance among microorganisms. This article presents an overview of analytical methodologies for the determination of quinolone (Qs) and fluoroquinolone (FQs), macrolide (MLs), tetracycline (TCs), sulfonamide (SAs) antibiotics and trimethoprim (TMP) in different environmental waters. The analysis of these antibiotics has usually been carried out by high-performance liquid chromatography (HPLC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) and to a lesser extent by ultraviolet (UV) or fluorescence detection (FD). A very important step before LC analysis is sample preparation and extraction leading to elimination of interferences and prevention of matrix effect and preconcentration of target analytes.

show abstract

Section: Screening Methodsmentioning

confidence: 99%

Section: Chromatographymentioning

confidence: 99%

Section: Sulfonamide Antibiotics and Trimethoprimmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Seifrtová¹,

Nováková²,

Lino³

et al. 2009

Analytica Chimica Acta

298

170

View full text Add to dashboard Cite

show abstract

“…Other methods for SPH determination are meant for the analysis of food or feeding stuffs [13][14][15], and biological fluids [16]. Few methods have been devoted to environmental samples [17][18][19][20], and these concern complex and high cost pre-sampling procedures, unsuitable for in situ or for routine control of waters such as those in the fish tanks.…”

Section: Introductionmentioning

confidence: 99%

Sulphonamide-imprinted sol–gel materials as ionophores in potentiometric transduction

Almeida

Moreira

Heitor

et al. 2011

Materials Science and Engineering: C

View full text Add to dashboard Cite

This work proposes different kind of solid-contact graphite-based electrodes for the selective determination of sulphonamides (SPHs) in pharmaceuticals, biological fluids and aquaculture waters. Sulfadiazine (SDZ) and sulfamethoxazole (SMX) were selected for this purpose for being the most representative compounds of this group. The template molecules were imprinted in sol-gel (ISG) and the resulting material was used as detecting element. This was made by employing it as either a sensing layer or an ionophore of PVC-based mem-branes and subsequent potentiometric transduction, a strategy never reported before. The corresponding non-imprinted sol-gel (NISG) membranes were used as blank. The effect of plasticizer and kind/charge of ionic lipo-philic additive was also studied. The best performance in terms of slope, linearity ranges and signal reproducibility and repeatability was achieved by PVC membranes including a high dielectric constant plasticizer and 15 mg of ISG particles. The corresponding average slope was −51.4 and −52.4 mV/decade, linear responses were 9.0 × 10 −6 and 1.7 × 10 −5 M, and limits of detection were 0.74 and 1.3 μg/mL for SDZ and for SMX, respectively. Good selectivity with log Kpotb−0.3 was observed for carbonate, chloride, fluoride, hydrogenocarbonate, nitrate, nitrite, phosphate, cyanide, sulfate, borate, persulphate, citrate, tartrate, salicylate, tetracycline, ciprofloxacin, sulphamerazine, sulphatiazole, dopamine, glucose, galactose, cysteine and creatinine. The best sensors were successfully applied to the analysis of real samples with relative errors ranging from −6.8 to +3.7%.

show abstract

Occurrence of the Antimicrobials Sulfamethoxazole and Trimethoprim in Hospital Effluent and Study of Their Degradation Products after Electrocoagulation

Martins

Mallmann

Arsand

et al. 2010

CLEAN Soil Air Water

View full text Add to dashboard Cite

In this study, an investigation was carried out into the occurrence of sulfamethoxazole (SMX) and trimethoprim (TMP) in the effluent of the university hospital (HUSM) of the UFSM. The degradation of these antimicrobials by the electrocoagulation (EC) process was also examined, in both the aqueous solution and hospital effluent, and a study was conducted in order to identify the subproducts formed. The experiments were optimized through factorial planning and, also, checked by response surface methodology. The best conditions for EC (achieving 58.0% of chemical oxygen demand (COD) reduction) were obtained by using 13 mA cm À2 , 500 mg L À1 of NaCl, and 30 mm of interelectrode distance. The quantification of SMX (27.8 mg L À1 ) and TMP (6.65 mg L À1 ) in the hospital effluent, and the identification of the degradation products were carried out through liquid chromatography-mass spectrometry quadrupole linear and ion trapping with electrospray ionization (LC-ESI-MS/MS_QTrap). Removals of 88.0% (degradation only) and 33.0% (adsorption only) were achieved for aqueous solutions of SMX and TMP, respectively, under optimized conditions. In hospital effluent samples, fortified with additions of SMX and TMP, corresponding removals of 16.0% (degradation) and 28.0% (adsorption) were achieved. This suggests that the EC process is efficient in degrading SMX in aqueous solution, although the same was not the case with TMP. The degradation products of SMX were identified (m/z 256.0 and 288.5); however, only the latter is mentioned in the literature. Toxicological aspects were not considered in this study.

show abstract

Solid phase extraction and HPLC determination of veterinary pharmaceuticals in wastewater

Cited by 123 publications

References 22 publications

An overview of analytical methodologies for the determination of antibiotics in environmental waters

An overview of analytical methodologies for the determination of antibiotics in environmental waters

Sulphonamide-imprinted sol–gel materials as ionophores in potentiometric transduction

Occurrence of the Antimicrobials Sulfamethoxazole and Trimethoprim in Hospital Effluent and Study of Their Degradation Products after Electrocoagulation

Contact Info

Product

Resources

About