Solid Phase and Stability Investigation of a Co-Crystal in the l-Valine/l-Leucine System
Vico Tenberg,
Matthias Stein,
Heike Lorenz
Abstract:Some amino acid systems are known to exhibit solid solution and/or co-crystal behavior upon crystallization, which significantly affects their phase diagrams and complicates the design of their purification processes. Such behaviors are observed in the l-valine/l-leucine system. In this work, the formation and stability of a 3:1 co-crystal of the two amino acids (designated as V3L) is further investigated. To accomplish the formation, liquid-assisted grinding, slurry equilibration, and sublimation experiments … Show more
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