Solid organ transplantation: Technical progress meets human dignity a review of the literature considering elderly patients’ health related quality of life following transplantation

Kniepeiss, Daniela; Wagner, Doris; Pienaar, Simon; Thaler, H; Porubsky, Christian; Tscheliessnigg, Karlheinz; Roller, Regina E.

doi:10.1016/j.arr.2011.06.003

Cited by 21 publications

(19 citation statements)

References 56 publications

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“…Data on the health-related quality of life following solid organ transplantation are very scarce (Kniepiess et al 2012). Although studies were able to show that patients have a different attitude towards solid organ donation, routine assessments and a psychological follow-up of transplanted patients are still missing widely especially in geriatric patient populations (Stadlbauer et al 2011;Herrero et al 2003;Solá et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Long-term quality of life of liver transplant recipients beyond 60 years of age

Werkgartner

Wagner

Manhal

et al. 2013

AGE

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Due to ameliorated surgery as well as better immunosuppression, the recipient age after liver transplantation has been extended over the past years. This study aimed to investigate the health related quality of life after liver transplantation in recipients beyond 60 years of age. The SF-36 was used to evaluate the recipients' health-related quality of life as standardized tool. It comprises 36 items that are attributed to 8 subscales attributed to 2 components: the physical component score and the mental component score. Differences in the health-related quality of life between the included aged recipients and age-matched general population as well as among female and male recipients. Aged recipients showed significantly lower scores in physical functioning (29 vs. 76, p=0.001), role physical (42 vs. 73, p=0.003), bodily pain (34 vs. 71, p=0.003), general health (28 vs. 59, p=0.001), vitality (25 vs. 61, p=0.001), social functioning (36 vs. 87, p=0.001), role emotional (46 vs. 89, p=0.001) as well as the physical component score (28 vs. 76, p= 0.001). Aged female recipients showed lower results as compared to males in social functioning, physical functioning, role physical, and social functioning (p= 0.03 respectively) but comparable results in the remaining. Quality of life seems to be an issue among aged recipients and should be assessed on a regular basis.

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Section: Discussionmentioning

confidence: 99%

Long-term quality of life of liver transplant recipients beyond 60 years of age

Werkgartner

Wagner

Manhal

et al. 2013

AGE

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“…Quality of life in old age reflects good physical and functional health, independence (control over one’s own life), positive attitude towards life and its events (psychological state), social activities and networking, and financial stability(8). The literature to date on older LT recipients has focused on survival, leaving a substantial gap in the knowledge of the aforementioned geriatric outcomes that contribute to quality of life (9). …”

Section: Introductionmentioning

confidence: 99%

Functional Status After Lung Transplantation in Older Adults in the Post-Allocation Score Era

Genao

Whitson

Zaas

et al. 2013

American Journal of Transplantation

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This manuscript describes the functional status trajectory of older (age 65 or older) and younger (age 18–64) adults after Lung Transplantation (LT). After the implementation of the Lung Allocation Score (LAS) in 2005, older adults became the fastest growing subgroup of recipients. Yet the impact of LT on physical function, a main determinant of quality of life in older adults, is unknown. We conducted a retrospective cohort study using United Network for Organ Sharing data on 4805 adults who received a LT during 2005–2009. We divided them into older (≥65, n=774) and younger (18–64, n=4031) cohorts. Functional status was measured by Karnofsky Performance Score (KPS). Mixed models estimated the impact of age group on the rate of functional decline starting at one-year post-transplantation. We controlled for KPS at transplantation, gender, race, diagnosis, LAS and LT type. Age group was not associated with different rates of decline in KPS over time. On average, recipients who were older, received a single LT, or had a low KPS at transplantation had worse functional status post-transplantation when compared to their counterparts, but rarely reached disability at 48-months. Overall, LT had a positive and durable effect on physical function for both older and younger recipients.

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“…In contrast, reports in heart, liver, and kidney transplants reveal similar outcomes in older vs. younger recipients [3]. Earlier publications in lung transplant patients also suggested that outcomes in recipients older than 60 were comparable with younger recipients.…”

Section: Agementioning

confidence: 89%