Solid lipid nanoparticles (SLNs), the potential novel vehicle for enhanced in vivo efficacy of hesperidin as an anti-inflammatory agent

Shahraki, Omolbanin; Shayganpour, Mohaddeseh; Hashemzaei, Mahmoud; Daneshmand, Sara

doi:10.1016/j.bioorg.2022.106333

Cited by 10 publications

(3 citation statements)

References 31 publications

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“…Comparing the spectra of CQ and LBN-CQ ( Figure 3 e), the disappearance of characteristic bands of CQ at 1576 cm −1 and 1041 cm −1 and band shifts from 1605 cm −1 to 1639 cm −1 and from 1200 cm −1 to 1217 cm −1 were observed. The disappearance or shifts of characteristic bands from CQ can indicate interactions of the drug with the nanosystem, reiterating its presence in the nanocarrier [ 62 , 63 , 64 , 65 , 66 ]. These findings, along with the high encapsulation efficiency, could be an indication of drug encapsulation in the nanoformulation [ 62 , 63 , 64 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

“…The disappearance or shifts of characteristic bands from CQ can indicate interactions of the drug with the nanosystem, reiterating its presence in the nanocarrier [ 62 , 63 , 64 , 65 , 66 ]. These findings, along with the high encapsulation efficiency, could be an indication of drug encapsulation in the nanoformulation [ 62 , 63 , 64 , 65 , 66 ].…”

Section: Resultsmentioning

confidence: 99%

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Development of a Clioquinol Nanocarrier as a New, Promising Option for the Treatment of Dermatomycosis

et al. 2023

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Dermatomycosis is a common fungal infection, and its treatment is limited by few antifungal agents. Clioquinol (CQ) is an antiparasitic agent that has been studied for new uses, such as antifungal and antiviral applications. CQ was incorporated into a lipid-based nanocarrier as a new, promising option for dermatomycosis. This study aimed to develop a CQ-loaded lipid-based nanocarrier for cutaneous application and to evaluate its antifungal activity. CQ-loaded nanoformulation (LBN-CQ) was developed using the ultrasonication method, and the particle size, polydispersity index (PDI), pH, zeta potential, and drug content were monitored for 45 days. To evaluate antifungal activity, broth microdilution and a time-kill assay were performed. LBN-CQ presented a particle size of 91 ± 3 nm and PDI of 0.102 ± 0.009. The zeta potential and pH values were −9.7 ± 2.0 mV and 6.0 ± 0.1, respectively. The drug content was 96.4 ± 2.3%, and the encapsulation efficiency was 98.4%. LBN-CQ was able to reduce the minimum inhibitory concentration (MIC) in a 2-fold or 4-fold manner in most of the tested strains. Additionally, LBN-CQ presented stable fungistatic action that was not concentration- or time-dependent. In conclusion, the developed CQ-loaded nanocarrier is a promising treatment for skin fungal infections and a promising candidate for future randomized clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Development of a Clioquinol Nanocarrier as a New, Promising Option for the Treatment of Dermatomycosis

et al. 2023

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“…Among the ways of application of colloidal systems based on solid lipids extensively documented in the literature are cosmetic [5,8,9], food [4,6,10], and, above all, in the pharmaceutical industry (i.e., drug delivery) [7,11,12]. In recent years, lipid formulations have enabled the effective encapsulation of active substances successfully delivered intravenously [13][14][15], orally [16][17][18], transdermally [19][20][21], and also directly into the eye [22][23][24] or nose [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Natural-Origin Betaine Surfactants as Promising Components for the Stabilization of Lipid Carriers

Pucek-Kaczmarek,

Celary,

Bazylińska

2024

IJMS

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In the present work, we demonstrate studies involving the influence of the formulation composition on the physicochemical properties of nanocarriers: solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). Novel lipid-origin platforms were prepared using two “green” betaine-based surfactants, cocamidopropyl betaine (ROKAmina K30) and coco betaine (ROKAmina K30B), in combination with three different solid lipids, cetyl palmitate (CRODAMOL CP), trimyristin (Dynasan 114), and tristearin (Dynasan 118). Extensive optimization studies included the selection of the most appropriate lipid and surfactant concentration for effective SLN and NLC stabilization. The control parameters involving the hydrodynamic diameters of the obtained nanocarriers along with the size distribution (polydispersity index) were determined by dynamic light scattering (DLS), while shape and morphology were evaluated by atomic force microscopy (AFM) and transmission electron microscopy (TEM). Electrophoretic light scattering (ELS) and turbidimetric method (backscattering profiles) were used to assess colloidal stability. The studied results revealed that both betaine-stabilized SLN and NLC formulations containing CRODAMOL CP as lipid matrix are the most monodisperse and colloidally stable regardless of the other components and their concentrations used, indicating them as the most promising candidates for drug delivery nanosystems with a diverse range of potential uses.

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Piperine-Loaded Zein Electrospun Nanofibers: Development, Characterization and Antibacterial Application

Daneshmand,

Shahraki,

Hosseynipour

et al. 2023

BioNanoSci.

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Solid lipid nanoparticles (SLNs), the potential novel vehicle for enhanced in vivo efficacy of hesperidin as an anti-inflammatory agent

Cited by 10 publications

References 31 publications

Development of a Clioquinol Nanocarrier as a New, Promising Option for the Treatment of Dermatomycosis

Development of a Clioquinol Nanocarrier as a New, Promising Option for the Treatment of Dermatomycosis

Natural-Origin Betaine Surfactants as Promising Components for the Stabilization of Lipid Carriers

Piperine-Loaded Zein Electrospun Nanofibers: Development, Characterization and Antibacterial Application

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