Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin

Talarico, Luigi; Consumi, Marco; Leone, Gemma; Tamasi, Gabriella; Magnani, Agnese

doi:10.3390/molecules26092694

Cited by 34 publications

(21 citation statements)

References 54 publications

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“…The antioxidant activity of quercetin-loaded SLNs was also confirmed by another research group [72]. Information has emerged on the anticarcinogenic effect of SLN-encapsulated quercetin [73].…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 62%

“…Both in vitro and in vivo experiments showed that NLCs loaded with quercetin provide a constant release of the flavonoid and its accumulation in the lungs, liver, and kidneys, which is important for its anticarcinogenic activity [72,90,91]. It has been shown that the quercetin release from NLCs exceeded that from SLNs [74].…”

Section: Nanostructured Lipid Carriersmentioning

confidence: 99%

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Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Zverev

Rykunova

2022

Appl Biochem Microbiol

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This review is devoted to modern systems of nanocarriers that ensure the targeted delivery of flavonoids to various organs and systems. Flavonoids have wide range of effects on the human body due to their antioxidant, anti-inflammatory, antitumor, antimicrobial, antiplatelet and other types of activity. However, the low bioavailability of flavonoids significantly limits their practical application. To overcome this disadvantage, serious efforts have been made in recent years to develop nanoscale carriers for flavonoids. This is particularly important in view of the known antitumor effect of these compounds, which allows them to target tumor cells without affecting surrounding healthy tissues. Nanocarriers provide increased penetration of biologicals into specific organs in combination with controlled and prolonged release, which markedly improves their effectiveness. This review summarizes data on the use of phytosomes, lipid-based nanoparticles, as well as polymeric and inorganic nanoparticles; their advantages and drawbacks are analyzed; the prospect of their use is discussed that opens new possibilities for the clinical application of flavonoids.

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Section: Solid Lipid Nanoparticlesmentioning

confidence: 62%

Section: Nanostructured Lipid Carriersmentioning

confidence: 99%

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Zverev

Rykunova

2022

Appl Biochem Microbiol

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“…For example, Qin et al [ 95 ] used solid lipid nanoparticles to encapsulate and deliver resveratrol, and found that resveratrol-loaded solid lipid nanoparticles were effective in enhancing antioxidant defense and conferring anti-fatigue capacity after extensive exercise in mice, which provides a valuable reference for resveratrol delivery systems within the field of novel anti-fatigue sports nutrition. Similarly, the bioavailability of other polyphenolic compounds such as quercetin was enhanced to varying degrees by the solid lipid nanocarriers [ 107 ]. In addition, nanoemulsions and liposomes are also effective delivery systems for lipophilic polyphenolic compounds, and provide excellent support for the enhancement of plant polyphenol bioavailability.…”

Section: Common Bio-based Polymer Nano-delivery Of Polyphenolic Compo...mentioning

confidence: 99%

Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

Zhang

Sang

et al. 2022

Foods

101

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Plant polyphenols have attracted considerable attention because of their key roles in preventing many diseases, including high blood sugar, high cholesterol, and cancer. A variety of functional foods have been designed and developed with plant polyphenols as the main active ingredients. Polyphenols mainly come from vegetables and fruits and can generally be divided according to their structure into flavonoids, astragalus, phenolic acids, and lignans. Polyphenols are a group of plant-derived functional food ingredients with different molecular structures and various biological activities including antioxidant, anti-inflammatory, and anticancer properties. However, many polyphenolic compounds have low oral bioavailability, which limits the application of polyphenols in nutraceuticals. Fortunately, green bio-based nanocarriers are well suited for encapsulating, protecting, and delivering polyphenols, thereby improving their bioavailability. In this paper, the health benefits of plant polyphenols in the prevention of various diseases are summarized, with a review of the research progress into bio-based nanocarriers for the improvement of the oral bioavailability of polyphenols. Polyphenols have great potential for application as key formulations in health and nutrition products. In the future, the development of food-grade delivery carriers for the encapsulation and delivery of polyphenolic compounds could well solve the limitations of poor water solubility and low bioavailability of polyphenols for practical applications.

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“…Talarico et al (2021) reported that the controlled release of Quercetin, a poorly water-soluble flavonoid, over 26 h was achieved with SLNs composed of stearic acid as core lipid and Arabic Gum as stabilizer. In addition, the SLNs were found to enhance antioxidant activity compared to free Quercetin [ 58 ]. Eugenol is a natural compound widely found in many aromatic plant species such as clove, holy basils, and betel vine.…”

Section: Slns and Nlcs As Topical Carriers For Anti-acne Phytochemicalsmentioning

confidence: 99%

A Mini-Review on Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Topical Delivery of Phytochemicals for the Treatment of Acne Vulgaris

2022

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Acne vulgaris (acne) is one of the most common dermatological problems affecting adolescents and young adults. Although acne may not lead to serious medical complications, its psychosocial effects are tremendous and scientifically proven. The first-line treatment for acne is topical medications composed of synthetic compounds, which usually cause skin irritation, dryness and itch. Therefore, naturally occurring constituents from plants (phytochemicals), which are generally regarded as safe, have received much attention as an alternative source of treatment. However, the degradation of phytochemicals under high temperature, light and oxygen, and their poor penetration across the skin barrier limit their application in dermatology. Encapsulation in lipid nanoparticles is one of the strategies commonly used to deliver drugs and phytochemicals because it allows appropriate concentrations of these substances to be delivered to the site of action with minimal side effects. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems developed from the combination of lipid and emulsifier. They have numerous advantages that include biocompatibility and biodegradability of lipid materials, enhancement of drug solubility and stability, ease of modulation of drug release, ease of scale-up, feasibility of incorporation of both hydrophilic and lipophilic drugs and occlusive moisturization, which make them very attractive carriers for delivery of bioactive compounds for treating skin ailments such as acne. In this review, the concepts of SLNs and NLCs, methods of preparation, characterization, and their application in the encapsulation of anti-acne phytochemicals will be discussed.

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Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin

Cited by 34 publications

References 54 publications

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Modern Nanocarriers as a Factor in Increasing the Bioavailability and Pharmacological Activity of Flavonoids

Polyphenols as Plant-Based Nutraceuticals: Health Effects, Encapsulation, Nano-Delivery, and Application

A Mini-Review on Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Topical Delivery of Phytochemicals for the Treatment of Acne Vulgaris

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