Solid Lipid Nanoparticles of Levamisole Hydrochloride

Abstract

Levamisole hydrochloride is a prominent anticancer drug in the treatment of colon cancer but resulted in toxic effects due poor bioavailability and poor cellular uptake by tumor cells. Levamisole is an unstable drug. Incorporation of this molecule in solid lipids may minimize their exposure to the aqueous environment and partly immobilize the drug molecules within the lipid matrix -both of which may protect the encapsulated drugs against degradation. The objectives of