Solid lipid nanoparticles for delivery of Calendula officinalis extract

Arana, Lide; Salado, Clarisa; Vega, Sandra; Aizpurua‐Olaizola, Oier; Arada, Igor de la; Suárez, Tatiana; Usobiaga, Aresatz; Arrondo, José Luis R.; Alonso, Alicia; Goñi, Félix M.; Alkorta, Itziar

doi:10.1016/j.colsurfb.2015.07.020

Cited by 52 publications

(30 citation statements)

References 35 publications

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“…[99][100][101][102][103][104][105] Besides the advantages of the herbal-based compounds in wound healing process, nanosizing these therapeutics or incorporation of these materials in nanoparticles provides a chance of controlling their delivery to the injured side and can increase their chemical activity. 106 For instance, nanosizing the curcumin particles provided a well-regulated and sustained delivery system and enhanced their wound healing activity by increasing the antimicrobial effect and accelerating the formation of granular tissues and collagen synthesis. 99,107 Nanoemulsions are nanostructures that provide the possibility to nanosize different essential oils.…”

Section: Incorporation Of Natural Products In Different Forms Of Nanomentioning

confidence: 99%

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Hajialyani¹,

Tewari²,

Sobarzo‐Sánchez³

et al. 2018

IJN

167

113

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Wound healing process is an intricate sequence of well-orchestrated biochemical and cellular phenomena to restore the integrity of the skin and subcutaneous tissue. Several plant extracts and their phytoconstituents are known as a promising alternative for wound healing agents due to the presence of diverse active components, ease of access, and their limited side effects. The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products. Here, we present a review of the efficacy of the plant based-nanomaterials in the management of wounds and discuss the involved therapeutic targets. For this purpose, a profound search has been conducted on in vitro, in vivo, and/or clinical evidences evaluating the efficacy and pharmacological mechanisms of natural product-based nanostructures on different types of wounds. Different pharmacological targets are involved in the wound healing effects of herbal-based nanostructures, including suppressing the production of inflammatory cytokines and inflammatory transduction cascades, reducing oxidative factors and enhancing antioxidative enzymes, and promoting neovascularization and angiogenic pathways through increasing the expression of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor. Moreover, nanostructure of plant extracts and their phytochemicals can enhance their bioavailability, control their release in the form of sustained delivery systems to the wound site, and enhance the permeability of these therapeutics to the underlying skin layers, which are all necessary for the healing process. Overall, various plant extracts and their natural compounds, used in nanoformulations, have demonstrated high activity in the management of wounds and thus can be assumed as future pharmaceutical drugs.

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Section: Incorporation Of Natural Products In Different Forms Of Nanomentioning

confidence: 99%

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Hajialyani¹,

Tewari²,

Sobarzo‐Sánchez³

et al. 2018

IJN

167

113

View full text Add to dashboard Cite

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“…Calendula officinalis extract was entrapped in SLN for ocular delivery and demonstrated its wound-healing capacity on cultured Wong-Kilbourne derivative of Chang Conjunctival Epithelial Cells [94].…”

Section: Corneal Wound Healingmentioning

confidence: 99%

Application of lipid nanoparticles to ocular drug delivery

Battaglia

Serpe

Foglietta

et al. 2016

Expert Opinion on Drug Delivery

120

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Although eye drops are widely used as drug delivery systems for the anterior segment of the eye, they are also associated with poor drug bioavailability due to transient contact time and rapid washout by tearing. Moreover, effective drug delivery to the posterior segment of the eye is challenging, and alternative routes of administration (periocular and intravitreal) are generally needed, the blood-retinal barrier being the major obstacle to systemic drug delivery. Areas covered: Nanotechnology, and especially lipid nanoparticles, can improve the therapeutic efficiency, compliance and safety of ocular drugs, administered via different routes, to both the anterior and posterior segment of the eye. This review highlights the main ocular barriers to drug delivery, as well as the most common eye diseases suitable for pharmacological treatment in which lipid nanoparticles have proved efficacious as alternative delivery systems. Expert opinion: Lipid-based nanocarriers are among the most biocompatible and versatile means for ocular delivery. Mucoadhesion with consequent increase in pre-corneal retention time, and enhanced permeation due to cellular uptake by corneal epithelial cells, are the essential goals for topical lipid nanoparticle delivery. Gene delivery to the retina has shown very promising results after intravitreal administration of lipid nanoparticles as non-viral vectors.

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“…Then it was loaded with Calendula officinalis extract. Calendula-loaded SLN were nontoxic, with a good stability and a good lyophilization profile, probably useful for prolonged storage conditions [72].…”

Section: Calendula Officinalismentioning

confidence: 99%

“…Calendula officinalis) is an annual culture plant species, part of the daisy family (Asteraceae), rarely biannual, 40-80 cm tall, with a powerful balsamic scent [69, 70].The Calendula officinalis extract contains different classes of compounds, such as triterpenoids, flavonoids, coumarins, quinones, volatile oil, carotenoids, and amino acids[71], but the active compound consists mainly of carotenoids (carotene, lycopene, flavoxanthin, lutein, and rubixanthin) and faradiol[72].…”

mentioning

confidence: 99%

Natural Compounds for Wound Healing

Georgescu¹,

Marinas²,

Popa³

et al. 2016

Worldwide Wound Healing - Innovation in Natural and Conventional Methods

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Many plants or plant-derived compounds with high levels of antioxidants and antiinflammatory, immunomodulatory, and antimicrobial properties could be of great benefit for wound healing. Several studies have documented the use of plant extracts for the development of bioactive wound dressings. The purpose of this chapter is to give an update about the vegetal and bee products, which can be used as bioactive substances in wound dressings or in other formulations for wound healing. The adverse effects of plant and bee extracts, such as contact allergies, are also presented. In order to better exploit the huge reservoir of pharmacologically active plant-derived compounds and extracts, standardized methodology and clinical trials are necessary to give more concrete evidence supporting the use of traditional medicine in wound management.

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Solid lipid nanoparticles for delivery of Calendula officinalis extract

Cited by 52 publications

References 35 publications

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Application of lipid nanoparticles to ocular drug delivery

Natural Compounds for Wound Healing

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