Solid Lipid Nanoparticles as Insulin Inhalation Carriers for Enhanced Pulmonary Delivery

Ru, Bi; Shao, Wei; Wang, Qun; Zhang, Na

doi:10.1166/jbn.2009.036

Cited by 65 publications

(22 citation statements)

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“…Particle engineering is also needed to achieve stabilization of large molecules (biopharmaceuticals) in the dry state with sugar glasses (cryoprotectants) [97][98][99][100][101], prolonged drug release or therapeutic effect (e.g. by mucoadhesion) [102][103][104][105][106][107], and enhanced drug absorption [106,108]. Particle processing can furthermore be used to prevent or retard moisture uptake by hygroscopic drugs [94,109,110], to escape macrophage clearance [111], or, in contrast, to target specifically the alveolar macrophages [112,113], even though the conditions that influence particle uptake by macrophages are still widely unknown [114].…”

Section: Formulation Of High-dose Drugsmentioning

confidence: 99%

“…The formulation has to contain the drug particles in the desired aerodynamic size distribution for deposition in the target area. Formulation design may be needed to achieve previously mentioned effects [97][98][99][100][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115][116] or a better product stability. DPI devices need to disperse the formulation effectively into this size distribution, preferably at the lowest possible flow rate within the first 0.5 L (children) or 1 L (adults) of inhaled air to achieve drug distribution over the entire lung.…”

Section: Dpi Design and Pulmonary Drug Deposition And Distributionmentioning

confidence: 99%

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Dry powder inhalation: past, present and future

Boer

Hagedoorn

Hoppentocht

et al. 2016

Expert Opinion on Drug Delivery

206

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Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts contained carrier-based formulations and lacked efficient dispersion principles. Therefore, particle engineering and powder processing are increasingly applied to achieve acceptable lung deposition with these poorly designed inhalers. Areas covered: The consequences of the choices made for early DPI development with respect of efficacy, production costs and safety and the tremendous amount of energy put into understanding and controlling the dispersion performance of adhesive mixtures are discussed. Also newly developed particle manufacturing and powder formulation processes are presented as well as the challenges, objectives, and new tools available for future DPI design. Expert opinion: Improved inhaler design is desired to make DPIs for future applications cost-effective and safe. With an increasing interest in high dose drug delivery, vaccination and systemic delivery via the lungs, innovative formulation technologies alone may not be sufficient. Safety is served by increasing patient adherence to the therapy, minimizing the use of unnecessary excipients and designing simple and self-intuitive inhalers, which give good feedback to the patient about the inhalation maneuver. For some applications, like vaccination and delivery of hygroscopic formulations, disposable inhalers may be preferred. ARTICLE HISTORY

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Section: Formulation Of High-dose Drugsmentioning

confidence: 99%

Section: Dpi Design and Pulmonary Drug Deposition And Distributionmentioning

confidence: 99%

Dry powder inhalation: past, present and future

Boer

Hagedoorn

Hoppentocht

et al. 2016

Expert Opinion on Drug Delivery

206

View full text Add to dashboard Cite

show abstract

“…Solid lipid-based nanoparticles have been investigated as insulin inhalation carriers for enhanced pulmonary delivery 59. …”

mentioning

confidence: 99%

Nanomedicine–Nanoscale Drugs and Delivery Systems

Singh

2010

J. Nanosci. Nanotech.

129

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Significant progress has been made in nanoscale drugs and delivery systems employing diverse chemical formulations to facilitate the rate of drug delivery and release from the human body. The biocompatible nanomaterials have been used in biological markers, contrast agents for biological imaging, healthcare products, pharmaceuticals, drug-delivery systems as well as in detection, diagnosis and treatment of various types of diseases. Nanomedicines offer delivery of potential drugs to human organs which were previously beyond reach of microscale drugs due to specific biological barriers. The nanoscale systems work as nanocarriers for the delivery of drugs. The nanocarriers are made of biocompatible and biodegradable materials such as synthetic proteins, peptides, lipids, polysaccharides, biodegradable polymers and fibers. This review article reports the recent developments in the field of nanomedicine covering biodegradable polymers, nanoparticles, cyclodextrin, dendrimeres, liposomes and lipid-based nanocarriers, nanofibers, nanowires and carbon nanotubes and their chemical functionalization for distribution to different organs, their solubility, surface, chemical and biological properties, stability and release systems. The toxicity and safety of nanomaterials on human health is also briefly discussed.

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“…SLNs possess other advantages such as controlled release, targeted delivery, and high loading efficiency while avoiding the use of organic solvents 28,29 . The dissolved or dispersed drug exists in the solid hydrophobic core, while excipients, including surfactants and phospholipids, are generally recognized as safe for clinical therapy.…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Polymeric multifunctional nanomaterials for theranostics

et al. 2015

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Nanocarriers provide a platform to integrate therapy and diagnostics, which is an emerging direction in medical practice. Beyond simply therapeutic functionality, theranostic nanomaterials have been designed to deliver multiple components and imaging agents, facilitating simultaneous and synergistic diagnosis and therapies. In this article, polymeric materials with diverse functionalities and properties for manufacturing theranostic nanomaterials are discussed and compared. We focused on recent advancements in polymeric multifunctional nanomaterials for synergistic theranostics. The drugs and imaging agents were encapsulated within and/or conjugated to the surface of the nanocarriers, according to the fabrication process and carrier type. In parallel with therapy, polymeric multifunctional nanomaterials can be exploited to exhibit distinctive magnetic, electrical, and optical properties for concomitant imaging. This has been accomplished by incorporating various imaging agents, such as fluorescent dyes, biomarkers, quantum dots, metal composites, and magnetic nanoparticles. We discussed theranostic nanomaterial synthesis, carrier fabrication and its applications. By presenting this comprehensive review of the state-of-the-art, we demonstrated that polymeric multifunctional nanomaterials exhibit distinctive advantages and features in theranostics. DisciplinesBiomechanics and Biotransport | Nanoscience and Nanotechnology | Polymer This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the Information for Authors.

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Solid Lipid Nanoparticles as Insulin Inhalation Carriers for Enhanced Pulmonary Delivery

Cited by 65 publications

References 0 publications

Dry powder inhalation: past, present and future

Dry powder inhalation: past, present and future

Nanomedicine–Nanoscale Drugs and Delivery Systems

Polymeric multifunctional nanomaterials for theranostics

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