Solid Lipid Nanoparticles Approach for Lymphatic Targeting Through Intraduodenal Delivery of Quetiapine Fumarate

Abstract

On the basis of results of in vitro study, Q9 formulation was selected as optimized formulation. It exhibited better bioavailability as compared to drug suspension. It can be concluded that solid lipid nanoparticles are potential carrier for improving quetiapine bioavailability through lymphatic delivery.

Enhanced Lymphatic Delivery of Methotrexate Using W/O/W Nanoemulsion: In Vitro Characterization and Pharmacokinetic Study

“…These findings also suggest that studies on lymphatic targeting and migration of anticancer drugs are crucial, and, in fact, researchers have studied a number of targeting strategies and benefits based on the structural and physiological characteristics of the lymphatic system related to drug delivery [ 6 , 7 , 8 , 9 ]. Researchers have also reported on improving bioavailability and efficacy through formulations of conventional drugs [ 10 , 11 , 12 , 13 ]. Formulation with polyaminoacid nanocapsule has been attempted to improve lymphatic delivery of docetaxel as an anticancer drug [ 10 ].…”

“…Formulation with polyaminoacid nanocapsule has been attempted to improve lymphatic delivery of docetaxel as an anticancer drug [ 10 ]. In addition to anticancer drugs, there were several studies to formulate nanostructured lipid carriers [ 11 ], solid lipid nanoparticles [ 12 ], and self-microemulsifying drug delivery systems [ 13 ] to improve lymphatic delivery for mebendazole, quetiapine, and saquinavir, respectively.…”

Preparation of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Drug Delivery and the Effects of Preparation Parameters of Solvent Injection Method

“…The method involves diluting a microemulsion in a cold aqueous solution, which results in the formation of nanoemulsion and the subsequent formation of SLNs and NLCs by lipid precipitation. Briefly, a drug is dissolved in molten lipids at a temperature above the lipids melting point, and then an aqueous phase containing water and surfactant (pre-heated to the same temperature) is added under mild stirring to form a transparent and thermodynamically stable microemulsion [ 79 , 80 ]. The microemulsion is then poured into a cold aqueous solution (2–10 °C) under gentle mechanical mixing [ 55 ].…”

Olive Leaves (<i>Olea europaea</i> L) Extract Loaded Lipid Nanoparticles: Optimization of Processing Parameters by Box-Behnken Statistical Design, <i>in-vitro</i> Characterization, and Evaluation of Anti-oxidant and Anti-microbial Activity

“…2 3D images showing the effect of independent variables on particle size. entrapment efficiency 41,42) .…”

“…A significant reduction (p＜0.05) in zeta potential (−19.27 mv) and entrapment efficiency (73.29％) and a significant increment (p＜0.05) in particle size (388.37 nm) was observed in the formulation stored at 40±2℃/75±5％ RH. It might be due to the partial loss of surfactant covering (hence zeta potential reduced) which leads to aggregation of particles (hence particle size increased) and leakage of a drug in the external environment (hence entrapment efficiency reduced) 42,45,46) .…”