Solid lipid nanoparticles: An effective lipid-based technology for cancer treatment

Akanda, Mushfiq; Mithu, Md Sadeque; Douroumis, Dennis

doi:10.1016/j.jddst.2023.104709

Cited by 14 publications

(5 citation statements)

References 74 publications

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“…Similarly, NLCs are modified SLNs in which the lipid phase consists of liquid lipids (oils) and solids at room temperature . The small size and lipid nature of SLNs and NLCs facilitate crossing the BBB, especially in the leaky tumor vasculature. , Regarding drug delivery to the CNS, both SLNs and NLCs have been confirmed to improve the treatment of several neurological diseases, such as Parkinson’s disease, Alzheimer’s disease, migraine, epilepsy, and brain cancer . Many studies demonstrated the superiority of NLCs and SLNs over other nanoparticles (e.g., PLGA NPs) to promote targeted delivery of drugs to the brain due to their lipid properties. − …”

Section: Permeation Mechanisms Of Nanoparticles Capable Of Crossing T...mentioning

confidence: 99%

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha,

Liu,

et al. 2024

ACS Nano

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The blood−brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels. Thus, the BBB also prevents the passage of various forms of therapeutic agents, nanocarriers, and their cargos. Recently, many multidisciplinary studies focus on developing cargo-loaded nanoparticles (NPs) to overcome these challenges, which are emerging as safe and effective vehicles in neurotheranostics. In this Review, first we introduce the anatomical structure and physiological functions of the BBB. Second, we present the endogenous and exogenous transport mechanisms by which NPs cross the BBB. We report various forms of nanomaterials, carriers, and their cargos, with their detailed BBB uptake and permeability characteristics. Third, we describe the effect of regulating the size, shape, charge, and surface ligands of NPs that affect their BBB permeability, which can be exploited to enhance and promote neurotheranostics. We classify typical functionalized nanomaterials developed for BBB crossing. Fourth, we provide a comprehensive review of the recent progress in developing functional polymeric nanomaterials for applications in multimodal bioimaging, therapeutics, and drug delivery. Finally, we conclude by discussing existing challenges, directions, and future perspectives in employing functionalized nanomaterials for BBB crossing.

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Section: Permeation Mechanisms Of Nanoparticles Capable Of Crossing T...mentioning

confidence: 99%

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Zha,

Liu,

et al. 2024

ACS Nano

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“…By selectively delivering drugs to specific cells and organelles, lipid formulations can reduce side effects and improve treatment outcomes. Additionally, lipid formulations can stabilize drugs, making them easier to store and transport [74]. Among the various lipid formulations, lipid nanoparticles are particularly promising due to their unique composition and structure.…”

Section: Lipid-based Nanoparticles In Skin Cancermentioning

confidence: 99%

Nanotechnology as a Promising Method in the Treatment of Skin Cancer

Adamus-Grabicka,

Hikisz,

Sikora

2024

IJMS

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The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use of nanoparticles and may allow for the early detection and monitoring of neoplastic changes and determining the effectiveness of treatment. This article briefly reviews the present understanding of the characteristics of skin cancers, their epidemiology, and risk factors. It also outlines the possibilities of using nanotechnology, especially nanoparticles, for the transport of medicinal substances. Research over the previous decade on carriers of active substances indicates that drugs can be delivered more accurately to the tumor site, resulting in higher therapeutic efficacy. The article describes the application of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles in existing therapies. It discusses the challenges encountered in nanoparticle therapy and the possibilities of improving their performance. Undoubtedly, the use of nanoparticles is a promising method that can help in the fight against skin cancer.

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“…These nanoparticles create stable nanosuspensions with longer-lasting effects compared to liposomal delivery systems. Furthermore, SLNs are versatile and can be administered via various routes, including dermal, oral, pulmonary, and parenteral [ 66 ].…”

Section: Types Of Nanomaterialsmentioning

confidence: 99%

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

Arafat,

Sakkal,

Beiram

et al. 2024

Pharmaceuticals

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Cancer continues to pose one of the most critical challenges in global healthcare. Despite the wide array of existing cancer drugs, the primary obstacle remains in selectively targeting and eliminating cancer cells while minimizing damage to healthy ones, thereby reducing treatment side effects. The revolutionary approach of utilizing nanomaterials for delivering cancer therapeutic agents has significantly enhanced the efficacy and safety of chemotherapeutic drugs. This crucial shift is attributed to the unique properties of nanomaterials, enabling nanocarriers to transport therapeutic agents to tumor sites in both passive and active modes, while minimizing drug elimination from delivery systems. Furthermore, these nanocarriers can be designed to respond to internal or external stimuli, thus facilitating controlled drug release. However, the production of nanomedications for cancer therapy encounters various challenges that can impede progress in this field. This review aims to provide a comprehensive overview of the current state of nanomedication in cancer treatment. It explores a variety of nanomaterials, focusing on their unique properties that are crucial for overcoming the limitations of conventional chemotherapy. Additionally, the review delves into the properties and functionalities of nanocarriers, highlighting their significant impact on the evolution of nanomedicine. It also critically assesses recent advancements in drug delivery systems, covering a range of innovative delivery methodologies. Finally, the review succinctly addresses the challenges encountered in developing nanomedications, offering insightful perspectives to guide future research in this field.

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Solid lipid nanoparticles: An effective lipid-based technology for cancer treatment

Cited by 14 publications

References 74 publications

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

Nanotechnology as a Promising Method in the Treatment of Skin Cancer

Nanomedicines: Emerging Platforms in Smart Chemotherapy Treatment—A Recent Review

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