Solid lipid nanoparticle and microemulsion for topical delivery of triptolide

Mei, Zhinan; Chen, Huabing; Weng, Ting; Yang, Yajiang; Yang, Xiangliang

doi:10.1016/s0939-6411(03)00067-5

Cited by 258 publications

(93 citation statements)

References 21 publications

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“…While being transported across the skin, SLNs probably expel IT from the SLN matrix. This phenomenon has been hypothesized in some investigations (37). SLNs were shown to improve the dermal localization of several topical therapeutic agents (38).…”

Section: Determination Of Human Percutaneous Absorption Of It After Imentioning

confidence: 76%

Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Golmohammadzadeh¹,

Somaye²,

Reza³

2012

Acta Pharmaceutica

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Isotretinoin (IT) is used orally for the treatment of severe acne that has not responded to other measures. IT has also been tried in a number of other skin disorders and in some forms of neoplastic disease. It has obvious adverse side effects in oral administration. The most common is dryness of the mucous membranes, visual disturbances, skeletal hyperostosis, and musculoskeletal symptoms. Elevation of serum triglycerides, blood glucose and hepatic enzymes has also been reported (1, 2). However, topical preparations of IT are available, such as creams and gels that show systemic absorption. The topical utility of IT is strongly limited by several disadvantages, such as skin irritation, very low water solubility, and high instability in the presence of light, air and heat. The aim of this study was to develop new solid lipid nanoparticles of isotretinoin (IT-SLNs) and evaluate the ability of IT-SLNs to improve photostability, reduce skin permeation and irritating effects. IT-SLNs were prepared by the hot high pressure homogenization method. Size, zeta potential and morphological characteristics of the preparations were assessed by transmission electron microscopy (TEM) and thermotropic properties with differential scanning calorimetry (DSC). IT-SLNs had a small average diameter of 74.05 ± 8.91 nm and high encapsulation efficiency (EE) of 80.6 ± 1.2 %. The results showed that the entrapment of IT into SLNs reduced significantly its photodegradation. The in vitro permeation data showed that IT-SLNs can accumulate in the different layers of the skin and prevent systemic uptake of IT in mouse skin. IT-SLNs also significantly increased IT accumulation in the different layers of the stratum corneum of human skin. IT-SLN formulation was significantly less irritating compared to commercial IT-GEL, which shows its potential for improving skin tolerability and being a carrier for topical delivery of IT.

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Section: Determination Of Human Percutaneous Absorption Of It After Imentioning

confidence: 76%

Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Golmohammadzadeh¹,

Somaye²,

Reza³

2012

Acta Pharmaceutica

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“…The results revealed that TP-SLN increased the acute anti-inflammatory activity, because TP penetrated further into the skin. 61 Martins et al developed and validated a simple high performance liquid chromatography method to determine the content of camptothecin (CP) in various organs in rats, after administration of CP via SLN. Their formulations utilized cetyl palmitate as the lipid, and polysorbate 80 as the surfactant, at 5% ratio by weight (w/w) and 2% (w/w).…”

Section: Solid Lipid Nanoparticles and Nanostructured Lipid Carriersmentioning

confidence: 99%

“…However, its clinical use is restricted, due to its poor water solubility and some toxic effects. To improve these disadvantages, a microemulsion (ME) system was developed by Mei et al 61 The researchers developed, characterized, and evaluated in vitro the permeation and anti-inflammatory activity of microemulsions associated with TP. The MEs were prepared with water (water phase), isopropyl myristate TP (oil phase) and Tween 80:1,2-propylene glycol (surfactant: co-surfactant).…”

mentioning

confidence: 99%

“…The results shows the highest anti-inflammatory effects by TP incorporated in microemulsions. 61 Extracts from the fruit pulp of Syagrus romanzoffiana (Cham.) Glassman (Arecaceae) were incorporated into o/w nanoemulsions prepared using the phase inversion method, with squalane as the oil phase, and a pair of oleic alcohol ethoxylated surfactants as non-ionic surfactants (Oleth-3: oleyl alcohol 3OE and oleic alcohol 20OE).…”

mentioning

confidence: 99%

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Nanotechnology-based drug delivery systems and herbal medicines: a review

Bonifácio¹,

Silva²,

Ramos³

et al. 2013

IJN

251

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Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nanostructured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology-based drug delivery systems and herbal medicines.

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“…Some drugs such as triptolide, triamcinolone acetonide acetate, cyclosporin A have been used to be entrapped in SLN [157][158][159]. SLN can be admixed to an already commercially available and established topical formulation, e.g.…”

Section: Applications Of Nanocarrier Systems In Topical/transdermal Dmentioning

confidence: 99%

Nanocarrier Systems for Transdermal Drug Delivery

Escobar-Chávez¹,

Rodríguez-Cruz²,

Domínguez-Delgado³

et al. 2012

Recent Advances in Novel Drug Carrier Systems

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is an open discussion, in one hand, the nanotechnologist continue making new and more sophisticated nanocarriers and in the other hand, toxicologist continue evaluating possible damaging effects.Whatever it happens, nanotechnology is the new era and nanomedicine cannot be taking off. New nanocarriers will be created and the entire scientist working in nanomedicine bet for it to be the cure of diseases that in this moment are difficult to deal with [3] The application of preparations to the skin for medical purposes is as old as the history of medicine itself, with references to the use of ointments and salves found in the records of Babylonian and Egyptian medicine. The historical development of permeation research is well described by Hadgraft & Lane [4]. Over time, the skin has become an important route for drug delivery in which topical, regional or systemic effects are desired. Nevertheless, skin constitutes an excellent barrier and presents difficulties for the transdermal delivery of therapeutic agents, since few drugs possess the characteristics required to permeate across the stratum corneum in sufficient quantities to reach a therapeutic concentration in the blood. In order to enhance drug transdermal absorption different methodologies have been investigated developed and patented [5,6]. Improvement in physical permeationenhancement technologies has led to renewed interest in transdermal drug delivery. Some of these novel advanced transdermal permeation enhancement technologies include: iontophoresis, electroporation, ultrasound, microneedles to open up the skin and more recently the use of transdermal nanocarriers [3,[7][8][9][10].A number of excellent reviews that have been published contain detailed discussions concerning many aspects of transdermal nanocarriers [11][12][13][14][15][16][17]. The present chapter shows an updated overview of the use of submicron particles and other nanostructures in the pharmaceutical field, specifically in the area of topical and transdermal drugs. This focus is justified due to the magnitude of the experimental data available with the use of these nanocarriers. The development of submicron particles and other nanostructures in the pharmaceutical and cosmetic fields has been emerged in the last decades for designing best formulations for application through the skin [18][19][20][21]. The skinThe skin is the largest organ of the body [22][23][24], accounting for more than 10% of body mass, and the one that enables the body to interact more intimately with its environment. Essentially, the skin consists of four layers: The SC, that is the outer layer of the skin (nonviable epidermis), and forms the rate-controlling barrier for diffusion for almost all compounds. It is composed of dead flattened, keratin-rich cells, the corneocytes. These dense cells are surrounded by a complex mixture of intercellular lipids, namely, ceramides, free fatty acids, cholesterol, and cholesterol sulphate. Their most important feature is that they are structured as ordered bilayer arrays [25]...

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Solid lipid nanoparticle and microemulsion for topical delivery of triptolide

Cited by 258 publications

References 21 publications

Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Improved photostability, reduced skin permeation and irritation of isotretinoin by solid lipid nanoparticles / Povećana fotostabilnost, smanjena permeacija i iritacija izotretinoina iz kruto-tekućih nanočestica

Nanotechnology-based drug delivery systems and herbal medicines: a review

Nanocarrier Systems for Transdermal Drug Delivery

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