Solid lipid excipients — Matrix agents for sustained drug delivery

Rosiaux, Yvonne; Jannin, Vincent; Hughes, Sophie; Marchaud, Delphine

doi:10.1016/j.jconrel.2014.06.004

Cited by 80 publications

(48 citation statements)

References 95 publications

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“…This showed the non-fickian mode of irbesartan release from the optimized formulation F3. These observations indicated that the drug release was not because of water penetration into the matrix, which explained the characteristic of a lipid-based system and zero order kinetics could be attributed to the release of drug by diffusion (Rosiaux et al, 2014;Silva et al, 2012).…”

Section: Discussionmentioning

confidence: 86%

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Soma

Attari

Reddy

et al. 2017

Braz. J. Pharm. Sci.

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Irbesartan is an antihypertensive with limited bioavailability and solid lipid nanoparticles (SLN) is one of the approaches to improve bioavailability. Solid lipid nanoparticles were prepared using glyceryl monostearate by solvent emulsification method followed by probe sonication. Irbesartan loaded SLNs were characterized and optimized by parameters like particle size, zeta potential, surface morphology entrapment efficiency and in vitro release. The optimized formulation was then further evaluated for the pharmacokinetic studies in Wistar rats. Irbesartan-loaded SLN of particle size 523.7 nm and 73.8% entrapment efficiency showed good bioavailability in Wistar rats and also showed optimum stability in the studies. The SLN prepared using glyceryl monostearate by solvent emulsification method leads to improve bioavailability of the drug.

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Section: Discussionmentioning

confidence: 86%

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Soma

Attari

Reddy

et al. 2017

Braz. J. Pharm. Sci.

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“…Drug release characteristics of polymer-based sustained drug delivery systems have been well reported, but relatively less on drug release from lipid-based excipients (Rosiaux et al, 2014). In this study, IBU was encapsulated as SLMs by three different lipidbased matrices, CA, SA or GB.…”

Section: Discussionmentioning

confidence: 96%

Spray congealing as a microencapsulation technique to develop modified-release ibuprofen solid lipid microparticles: the effect of matrix type, polymeric additives and drug–matrix miscibility

Wong

Heng

Chan

2015

Journal of Microencapsulation

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This study aimed to achieve modified-release of ibuprofen (IBU) by encapsulation within lipid-based matrix materials [cetyl alcohol (CA), stearic acid (SA) and glyceryl dibehenate (GB)] using spray congealing to produce solid lipid microparticles (SLMs). Polymeric additives, polyvinyl-2-pyrrolidone-vinyl-acetate and ethylcellulose, were employed as release-modifying agents. Spray-congealed SLMs yield, scanning electron microscopy (SEM)-based morphology, particle size, drug content and entrapment efficiency were investigated. The influence of matrix type, additive type and concentration and drug-matrix miscibility on release of IBU was elucidated. Yields (81.4-96.4%) and drug encapsulation efficiencies (88.4-100%) of SLMs were high for all formulations. SLMs were generally discrete, spherical and dense. Increasing additives concentration led to not only larger median size SLMs but also faster drug release due to increased hydrophilicity conferred by the additives. Solid solution systems (SA-IBU, GB-IBU) sustained the release of IBU better than solid dispersion system (CA-IBU). CA- and GB-based SLMs closely adhered to the Weibull model of drug release, while SA counterparts followed the Korsmeyer-Peppas model.

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“…The lipids attract attention as they can help improve pharmaceutical product cycle and are cost-effective. They are used in various drug delivery systems intended to improve oral bioavailability and esthetics of the drug [1].…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of Food Grade Wax Matrix Sustained Release Mini-Tablets of Montelukast Sodium

Deshpande¹,

Wasul²

2017

Asian J Pharm Clin Res

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Objective: The objective of this study is to formulate a tablet that fits in the size range of mini-tablets using wax matrix forming substances, allows variation of drug dose and study of drug release kinetics of the dosage form. Methods:The blends of drug with glyceryl monostearate, purified rice bran wax and carnauba wax that renders the waxes food grade, were prepared and evaluated for precompression characteristics. The blends were compressed into mini-tablets having desirable physical characteristics and were subjected to tests such as weight variation and friability. The tablets were subjected to drug dissolution test and the release parameters were mathematically treated for order and mechanism of drug release. Results:The tablets complied with the pharmacopoeial standards of physical characteristics. The release was satisfactorily sustained (up to 10 hrs) by carnauba wax and rice bran wax, but not by glyceryl monostearate (only up to 4 hrs). The release followed a zero order with super Case II transport being the major mechanism of drug release. Conclusion:Wax matrix formers were satisfactorily used for sustained drug release mini-tablets. The tablets had good physical characteristics with major mechanism of drug release being super Case II transport.

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Solid lipid excipients — Matrix agents for sustained drug delivery

Cited by 80 publications

References 95 publications

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Solid lipid nanoparticles of irbesartan: preparation, characterization, optimization and pharmacokinetic studies

Spray congealing as a microencapsulation technique to develop modified-release ibuprofen solid lipid microparticles: the effect of matrix type, polymeric additives and drug–matrix miscibility

Design and Evaluation of Food Grade Wax Matrix Sustained Release Mini-Tablets of Montelukast Sodium

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