Solid Intraventricular Papillary Glioneuronal Tumor: Magnetic Resonance Imaging Findings With Histopathological Correlation

Portela-Oliveira, Eduardo; Torres, Ulysses S.; Lancellotti, Carmen Lúcia Penteado; Souza, Antônio Soares; Ferraz-Filho, José Roberto Lopes

doi:10.1016/j.pediatrneurol.2013.10.007

Cited by 9 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

et al. 2014

View full text Add to dashboard Cite

Papillary glioneuronal tumor (PGNT) is a rare type of primary brain tumor. Although PGNT has traditionally been defined as a clinically indolent neoplasm, several cases with high proliferative activity and tumor recurrence have recently been reported. We report a case of PGNT in a 12-year-old boy who presented with epilepsy and harbored a 64 mm cystic tumor with a high proliferative component in the right temporal lobe. (11) C-methionine positron emission tomography (PET) showed high uptake in the solid mass. Gross total resection of the tumor mass was achieved and the patient became seizure-free without any neurological deficits. Histologically, the tumor contained two distinct areas of a vasocentric papilliform structure and a desmoplastic component. Minigemistocytic cells and small necrotic regions were observed adjacent to the pseudopapillae. Immunohistochemical analyses revealed both glial and neuronal differentiation. The Ki-67 proliferation index was high (14%) in the area corresponding to the high uptake region in the (11) C-methionine PET. No tumor recurrence was observed 20 months after surgery. High proliferative PGNTs are rare and to our knowledge this is only the third pediatric case of PGNT with atypical features reported in the literature. Hence, we here review the reported cases of PGNT and discuss the clinical, radiological and histological features of this malignancy.

show abstract

“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Only 150 cases of PGNTs are reported up to now in the literature [36,31,17,11,41,15,12,2]. Amongst these, only 41 cases are reported in pediatric population which demonstrates rarity of this pathology in this age group [11,43,44,32,35,29,26,8,1,42,30,33,28,34,20,18,19,14,16,3,39,13,10,38,7,25,9,4,23]. To our 3 knowledge, there is no report of PGNT in a toddler up to now.…”

Section: Background and Importancementioning

confidence: 93%

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Tavallaii

Keykhosravi

Rezaee

2020

British Journal of Neurosurgery

View full text Add to dashboard Cite

Background and Importance: Papillary glioneuronal tumor is a recently known entity in central nervous system tumors. These benign WHO grade I tumors are mostly seen in young adults. Pediatric PGNT is rare and there is no report of these tumors in toddlers. Headache, nausea/vomiting and seizure are most common clinical symptoms. Acute presentation with focal neurological deficits or loss of consciousness are not amongst the expected presentations. These tumors are typically cystic with enhancing mural nodule. Although case with chronic intermittent microhemorrhages are reported in the literature but overt intra-tumoral hemorrhage is an odd radiological presentation with just one reported case in the literature. Clinical presentation: We present an extremely rare case of PGNT presenting with sudden onset hemiparesis and impaired consciousness due to acute intra-tumoral hemorrhage in a toddler which was surgically treated with favorable outcome. Conclusion: PGNTs can also be seen in very young children even in toddlers. Also, it should be kept in mind that these tumors have potential for overt intra-tumoral hemorrhage and acute presentation with focal neurological deficits mimicking more common pathologies which should be considered to plan optimal patient management.

show abstract

“…Only 150 cases of PGNTs are reported up to now in the literature [36,31,17,11,41,15,12,2]. Amongst these, only 41 cases are reported in pediatric population which demonstrates rarity of this pathology in this age group [11,43,44,32,35,29,26,8,1,42,30,33,28,34,20,18,19,14,16,3,39,13,10,38,7,25,9,4,23]. To our knowledge, there is no report of PGNT in a toddler up to now.…”

Section: Background and Importancementioning

confidence: 98%

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: An odd presentation of a rare pathology

Tavallaii

Keykhosravi

Rezaee

2020

Preprint

View full text Add to dashboard Cite

Background and Importance: Papillary glioneuronal tumor is a recently known entity in central nervous system tumors. These benign WHO grade I tumors are mostly seen in young adults. Pediatric PGNT is rare and there is no report of these tumors in toddlers. Headache, nausea/vomiting and seizure are most common clinical symptoms. Acute presentation with focal neurological deficits or loss of consciousness are not amongst the expected presentations. These tumors are typically cystic with enhancing mural nodule. Although case with chronic intermittent microhemorrhages are reported in the literature but overt intra-tumoral hemorrhage is an odd radiological presentation with just one reported case in the literature.Clinical presentation: We present an extremely rare case of PGNT presenting with sudden onset hemiparesis and impaired consciousness due to acute intra-tumoral hemorrhage in a toddler which was surgically treated with favorable outcome.Conclusion: PGNTs can also be seen in very young children even in toddlers. Also, it should be kept in mind that these tumors have potential for overt intra-tumoral hemorrhage and acute presentation with focal neurological deficits mimicking more common pathologies which should be considered to plan optimal patient management.

show abstract

Solid Intraventricular Papillary Glioneuronal Tumor: Magnetic Resonance Imaging Findings With Histopathological Correlation

Cited by 9 publications

References 4 publications

Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: An odd presentation of a rare pathology

Contact Info

Product

Resources

About