Solid Dispersions: Revival with Greater Possibilities and Applications in Oral Drug Delivery

Abstract

For Abstract see ChemInform Abstract in Full Text.

Dissolution enhancement of atorvastatin calcium by co-grinding technique

“…These include cyclodextrin complexation, use of surfactants, salt formation, particle size reduction through nanosuspension formation and micronization, pro-drug formation, use of solid dispersions, etc. However, each of the aforementioned strategies has disadvantages: prodrug formation results in the generation of a new chemical entity; salt formation is only possible for acidic or basic compounds; use of surfactants and cyclodextrins raises toxicity concerns; particle size reduction results in agglomeration, poor wettability and flow properties and dust generation [6]. Solid dispersions present a promising approach to enhance release of poorly soluble drugs among all the above-mentioned techniques [5,7].…”

Mechanistic Investigation of Pluronic® Based Nano-crystalline Drug-polymer Solid Dispersions

“…Common strategies to overcome low aqueous solubility and slow dissolution rate include particle size reduction of crystalline drugs, crystal lattice destruction by forming stabilized amorphous drug-polymer solid dispersions, and solublized systems such as lipid-based formulations (1)(2)(3)(4)(5)(6)(7). The rationale behind these strategies can be readily explained by the Noyes-Whitney relationship (8), and the selection of one strategy over the other depends on various factors, such as the physiochemical properties of the drug, dose to be delivered, scalability, robustness and manufacture of the formulations, and drug product stability.…”

“…One of the more frequently reported strategies in the pharmaceutical literature has been the amorphous drugpolymer solid dispersions (3,5,6). In this type of system, drug and polymers are co-processed, often by spray drying or hotmelt extrusion, to form an amorphous solid solution or dispersion, wherein polymers usually act as crystallization inhibitors to the amorphous drug.…”

Investigation of Atypical Dissolution Behavior of an Encapsulated Amorphous Solid Dispersion

“…However, literature reports have indicated poor dissolution performance of ASD-based drug products, 6,7 which is one of the challenges that limits their commercial application. The dissolution of amorphous solids involves multiple simultaneously occurring processes that can impact the overall drug release performance.…”

“…[12][13][14][15] Furthermore, in a dosage form, solid-liquid interfacial phenomena such as wetting, disintegration, and dispersibility can become the rate controlling step for drug release. In some cases, binder properties of polymeric stabilizers (observed for high molecular weight polymers or when used at high concentration levels), 7,[16][17][18] and drug recrystallization in the matrix or at the solid surface 10,19 have been implicated for nonoptimal drug release from dosage form. Drooge et al 10 decribed anamolous dissolution behavior of noninteracting ASD tablets, comprising of diazepam and sugar carriers, to be a result of fast leaching of carriers and drug recrystallization.…”