Solid Dispersions: Revival with Greater Possibilities and Applications in Oral Drug Delivery

Abstract

Improvement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Solid dispersions seem to be a viable technique for overcoming this problem. However, the practical applicability of these systems has remained limited because of difficulties in conventional methods of preparation, poor reproducibility of physicochemical properties, difficulties in dosage form development, and lack of feasibility for scale-up of manufacturing processes. This review addresses various aspects of solid dispersions and compiles some of the recent technology transfers from various fields such as the chemical, food, and polymer industries for the preparation of solid dispersions that can lead to highly efficient and controlled large-scale manufacturing. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with an insight into the release mechanism of drugs are also discussed. Finally, an in-depth rationale for limited commercialization of solid dispersions and recent revival has been considered.

Electrospun nanofiber-based drug delivery systems

“…[27] However, the practical applicability of solid dispersion systems has remained limited due to difficulties in conventional methods of preparation, poor reproducibility of physiochemical properties, dosage formulation and lack of feasibility for scaling-up manufacturing processes. [28] Electrospun nanofibers may provide novel approaches as to how the dissolution rate of even very poorly soluble compounds might be improved to minimize the limitations of oral availability.…”

Development and Evaluation of Praziquantel Solid Dispersions in Sodium Starch Glycolate

“…The SD technique produces a significant increase in surface area and surface wettability as well as solid state modification from crystalline to amorphous form. However, the SD characteristics can be influenced by several factors such as preparation method, carrier type and drug:carrier ratio and pH modifiers [7,8].…”

Avaliação Do Perfil De Dissolução Da Glibenclamida Cristalizada Por Processo De Precipitação Com Antissolvente Líquido

“…Tendo em vista que a absorção de medicamentos administrados por via oral ocorre em duas etapas, sendo estas dissolução e permeabilidade intestinal (SETHIA e SQUILLANTE, 2003;YUKSEL, KANIK e BAYKARA, 2000), tais variáveis influenciam a biodisponibilidade oral (CHILLISTONE e HARDMAN, 2011). Como a GLIB está disposta na classe II do Sistema de Classificação Biofarmacêutico (NETO, 2012;PUIGJANER e PROHENS, 2007;REHDER et al, 2012;SHAH et al, 2013;WEI et al, 2008), apresentando baixa solubilidade e alta permeabilidade, sua absorção se torna limitada pela taxa de dissolução (AMIDON et al, 1995).…”