Solid dispersions based on inulin for the stabilisation and formulation of Δ9-tetrahydrocannabinol

Polymeric systems for amorphous Δ9-tetrahydrocannabinol produced by a hot-melt method. Part I: Chemical and thermal stability during processing

“…THC is a brown, oily resin that is viscous and sticky at ambient conditions and hardens upon refrigeration, suggesting that the glass transition temperature (T g ) is below 258C, necessitating its storage at relatively low temperatures for stability purposes. Indeed, T g of the drug was well below room temperature as determined by van Drooge et al 2 The stability of THC has been a subject of numerous investigations [3][4][5][6][7][8][9][10][11][12] and it has been reported that the drug is susceptible to decomposition by light, heat, and oxidation. Storage leads to a cumulative decrease in THC content through its oxidation to cannabinol (CBN), which is the most widely recognized thermo-oxidative degradation product of THC.…”

Enhanced Solubility, Stability, and Transcorneal Permeability of Delta-8-Tetrahydrocannabinol in the Presence of Cyclodextrins

“…Therefore, in contrast to currently available drugs, topical administration of Δ 9 -THC would not only reduce the IOP but would also protect the retinal ganglionic cells against glutamate and N-methyl-D-aspartate-induced neurotoxicity. However, Δ 9 -THC is psychotropic, poorly soluble in aqueous media, and has undesirable side effects (10,11). Moreover, susceptibility to oxidation, hydrolysis, thermal, and photolytic degradation in the solution form make the design of Δ 9 -THC ophthalmic formulations a challenging task (11)(12)(13)(14).…”

Chemistry and Biological Activity of Tetrahydrocannabinol and its Derivatives

“…These two strategies have been applied for ∆9-THC production by solid dispersion technology and production of nanosuspensions. Van Drooge et al, created a solid dispersion of inulin in which ∆9-THC was incorporated [151]. Applying freeze drying techniques for evaporation of a mixture of water and tertiary butyl alcohol, which acts as dissolving medium for ∆9-THC and inulin, forms amorphous ∆9-THC in a fast-dissolving solid inulin matrix.…”

“…Applying freeze drying techniques for evaporation of a mixture of water and tertiary butyl alcohol, which acts as dissolving medium for ∆9-THC and inulin, forms amorphous ∆9-THC in a fast-dissolving solid inulin matrix. The main advantage of the technique is to protect ∆9-THC from degeneration and to optimize the dissolution rate from tablets [151]. A second and easy way to increase the solubility can be achieved by reduction of the particle size.…”