Solid dispersions based on chitosan/hypromellose phthalate blends to modulate pharmaceutical properties of zidovudine

Pedreiro, Liliane Neves; Boni, Fernanda Isadora; Cury, Beatriz Stringhetti Ferreira; Ferreira, Natália Noronha; Gremião, Maria Palmira Daflon

doi:10.1080/10837450.2022.2097258

Cited by 2 publications

(1 citation statement)

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“…No drug-polymer interactions were observed using FTIR studies. Thus, the prepared solid dispersion proved to be a feasible strategy to modulate the physio-chemical, mucoadhesive, and drug release properties [90].…”

Section: Mucoadhesive Drug Delivery Systemmentioning

confidence: 99%

Chitosan-Based Polymer Blends for Drug Delivery Systems

et al. 2023

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Polymers have been widely used for the development of drug delivery systems accommodating the regulated release of therapeutic agents in consistent doses over a long period, cyclic dosing, and the adjustable release of both hydrophobic and hydrophilic drugs. Nowadays, polymer blends are increasingly employed in drug development as they generate more promising results when compared to those of homopolymers. This review article describes the recent research efforts focusing on the utilization of chitosan blends with other polymers in an attempt to enhance the properties of chitosan. Furthermore, the various applications of chitosan blends in drug delivery are thoroughly discussed herein. The literature from the past ten years was collected using various search engines such as ScienceDirect, J-Gate, Google Scholar, PubMed, and research data were compiled according to the various novel carrier systems. Nanocarriers made from chitosan and chitosan derivatives have a positive surface charge, which allows for control of the rate, duration, and location of drug release in the body, and can increase the safety and efficacy of the delivery system. Recently developed nanocarriers using chitosan blends have been shown to be cost-effective, more efficacious, and prolonged release carriers that can be incorporated into suitable dosage forms.

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Section: Mucoadhesive Drug Delivery Systemmentioning

confidence: 99%