Solid Cancers in the Premature and the Newborn: Report of Three National Referral Centers

Raciborska, Anna; Bilska, Katarzyna; Węcławek-Tompol, Jadwiga; Ussowicz, Marek; Pogorzała, Monika; Janowska, Joanna; Rychłowska-Pruszyńska, Magdalena; Rodríguez‐Galindo, Carlos; Helwich, Ewa

doi:10.1016/j.pedneo.2015.08.007

Cited by 15 publications

(10 citation statements)

References 20 publications

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“…The study performed in Poland reported an overall treatment-related mortality of 2.9% wherein 1/37 patient died from surgery-related complications. 7 The study performed in Los Angeles reported an overall treatment-related mortality of 2.2% wherein 1/45 patient died, also from surgery-related complications. 13 The study performed in France reported an overall treatment-related mortality of 5.3%, wherein 15/285 patients died from surgery-related complications.…”

Section: Discussionmentioning

confidence: 97%

“…4 Several studies only reviewed patients diagnosed with malignant neonatal tumours. 5,7,8,19 The largest of these studies were conducted in France, where they identified 285 neonates from the French National Registry of Childhood Solid Tumours with malignant tumours over a 9-year period. 19 Neuroblastomas were identified as the most common malignant solid tumour diagnosed and comprised 134/285 (47%) of the patient population.…”

Section: Discussionmentioning

confidence: 99%

“…19 Other studies conducted in high-income countries also identified neuroblastomas as the most frequently diagnosed malignant neonatal tumours followed by retinoblastomas, malignant germ cell tumours, renal tumours and hepatoblastomas. 5,7,8 In this study, malignant soft tissue tumours were identified as the most common malignant tumour diagnosed in neonates and included 7/16 (43.8%) patients.…”

Section: Discussionmentioning

confidence: 99%

“…A study performed in Poland analysed the data of 37 neonates and reported an overall survival of 80.4%. 7 A study performed in Los Angeles analysed the data of 45 neonates and reported an overall survival of 72%. 13 A study performed in France analysed the data of 285 neonates and reported an overall survival of 84.2%.…”

Section: Discussionmentioning

confidence: 99%

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Neonatal tumours: A single centre review

Schickerling

2017

S. Afr. j. oncol.

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Background: Neonatal tumours, occurring within 28 days of life, are associated with a favourable outcome in high-income countries. Limited data are available on neonatal tumours in low- and middle-income countries. Aim: We aimed to create awareness of neonatal tumours in a middle-income country, by identifying the most common tumours diagnosed to determine whether there was a delay to presentation or diagnosis at the Paediatric Oncology unit, to identify possible areas of improvement and increase overall survival. Setting: Chris Hani Baragwanath Academic Hospital Paediatric Oncology unit. Methods: A retrospective case series was performed collecting data on 60 neonates diagnosed with a tumour over a 25-year period (1 January 1988 to 31 December 2012). Descriptive statistical analysis using percentages and medians were used. Kaplan–Meier analysis was used to calculate survival. Results: Germ cell tumours were identified as the most common neonatal tumours diagnosed 29/60 (48.3%), whereas malignant soft tissue tumours were the most common malignant tumours identified. The median delay to presentation was 7 days, the median diagnostic delay was 11 days and the median overall delay was 30 days. The overall 5-year survival rate was 67.3%, with an overall 5-year survival of 54.1% of neonates diagnosed with a malignant tumour. Conclusion: A large percentage of neonates diagnosed with malignant tumours in highincome countries can be successfully treated and cured. Clinicians involved in the care of neonates need to be better acquainted with disease-specific signs of neonatal tumours to allow for early detection and referral to a Paediatric Oncology unit.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neonatal tumours: A single centre review

Schickerling

2017

S. Afr. j. oncol.

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“…Neuroblastoma (NB) is the most common malignant paediatric solid tumour outside the central nervous system and the most common malignancy in newborns 1. NB cells simulate the morphology of fetal neuroblasts and the tumour is assumed to arise from neural crest progenitors 2.…”

Section: Introductionmentioning

confidence: 99%

Neuroblastoma with flat genomic profile: a question of representativity?

et al. 2018

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Neuroblastoma is one of the most common paediatric malignancies. Detection of somatic genetic alterations in this tumour is instrumental for its risk stratification and treatment. On the other hand, an absence of detected chromosomal imbalances in neuroblastoma biopsies is difficult to interpret because it is unclear whether this situation truly reflects the tumour genome or if it is due to suboptimal sampling. We here present a neuroblastoma in the left adrenal of a newborn. The tumour was subjected to single-nucleotide polymorphism array analysis of five tumour regions with >80% tumour cells in histological mirror sections. This revealed no aberrations compared with a normal reference sample from the patient. Whole exome sequencing identified two single-nucleotide variants present in most tumour regions, corroborating that the tumour resulted from monoclonal expansion. Our data provide proof-of-principle that rare cases of neuroblastoma can have a normal whole genome copy number and allelic profile.

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