Solid as solvent-Novel Spectrophotometric Analytical Method for Metronidazole Tablets using Solids (Eutectic Liquid of Phenol and Niacinamide) as Solubilizing Agents (Mixed Solvency Concept)

Maheshwari, R. K.; MASHEER, KHAN AHMED; Maheshwari, Nupur; Maheshwari, Neelesh

doi:10.5958/0974-360x.2016.00132.3

Cited by 5 publications

(6 citation statements)

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“…In the previous study done by Maheshwari et Al, 19 norfloxacin was observed to be 0.88 mg/mL soluble in distilled water at room temperature. In the present investigation, the solubility of norfloxacin in the blend solution (20% urea + 20% sodium benzoate solution) was found to be 11 mg/mL.…”

Section: Resultsmentioning

confidence: 99%

“…The idea of hydrotropy can be realized. 12 13 14 15 16 17 Green chemistry can benefit from the ideas of hydrotropy and mixed hydrotropy. 18 Norfloxacin is a kind of antibiotic.…”

Section: Introductionmentioning

confidence: 99%

“…It has extremely poor solubility in water (0.88 mg/mL). 19 Hence, it is a poorly water-soluble drug and its solubility must be improved. The solubility of this drug can be increased with the help of hydrotropy and the mixed hydrotropy method.…”

Section: Introductionmentioning

confidence: 99%

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Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

Soni

Sharma

2021

Journal of Health and Allied Sciences NU

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Objectives The main aim of the research was to analyze an economical and eco-friendly approach to improve the solubility of norfloxacin. The current analysis was to utilize the hydrotropic solutions to extract the drugs from their dosage forms, avoiding the use of costlier and harmful organic solvents. Materials and Methods In this study, an ultraviolet–visible spectrophotometer (model 1800, Shimadzu Corporation) was used to analyze the norfloxacin drug. The mixed hydrotropy approach was used to determine the solubility of norfloxacin. In this work, a blend solution (20% of urea + 20% of sodium benzoate) was used as a hydrotropic solubilizing agent. Results The solubility of norfloxacin drug in water was very low at ∼0.88 mg/mL and the solubility of norfloxacin drug in the blend solution was 11 mg/mL. From 98.96 (tablet II) to 99.35 (tablet I), the percent estimation value was achieved. This value was nearly 100, so the proposed method was correct. Standard deviation (0.2540–0.4156), percentage coefficient of variation (0.2566–0.4183), and the value of standard error (0.1481–0.2415) are also very low; hence, we can say that the proposed method is accurate. Conclusion To avoid the use of organic solvents, the mixed hydrotropy concept can be used for spectrophotometric estimation of low water-soluble drugs from bulk drug samples. It provides an economical and environmentally friendly mechanism.

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Section: Resultsmentioning

confidence: 99%

“…The idea of hydrotropy can be realized. 12 13 14 15 16 17 Green chemistry can benefit from the ideas of hydrotropy and mixed hydrotropy. 18 Norfloxacin is a kind of antibiotic.…”

Section: Introductionmentioning

confidence: 99%

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Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

Soni

Sharma

2021

Journal of Health and Allied Sciences NU

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“…For a desired solubility enhancement, a single solubilizer may prove toxic for human being but the combination of different excipients in safe smaller concentrations solves the problem of toxicity for same desired solubility of drug. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] In present research work mixed solvency concept has been employed to formulate vaginal film of poorly water soluble drug, metronidazole.…”

Section: Mixed Solvency Conceptmentioning

confidence: 99%

Formulation and development of vaginal films of poorly water soluble drug, metronidazole, using mixed solvency concept and their evaluations

Gahlot

Maheshwari²

2018

J. Drug Delivery Ther.

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Aim: To deliver antibacterial therapy in an efficacious way, film dosage form has been proposed for drug delivery in vagina which can overcome bioavailability issues of poorly water soluble drugs. The present research work is aimed to explore the application of mixed solvency concept to increase solubility of poorly water soluble drug, metronidazole. Materials and Methods: Metronidazole, a slightly soluble drug in water was tried to be solubilized by employing the combination of solubilizers like niacinamide, sodium benzoate, sodium caprylate, caffeine and urea to endeavour its fast dissolving film formulations. The procured sample of drug was characterized by UV, IR and DSC studies. The formulations were evaluated for various properties of film such as thickness, folding endurance, surface pH, disintegration time and thin layer chromatography. Stability studies of vaginal films of metronidazole were performed for ten weeks at room temperature, and refrigerated conditions. Results and Discussion: It was found that 97.54% and 97.58% of drug was remaining after stability study at respective temperatures in batch F1 and 98.53% and 96.57% in batch F4.Conclusion: It was concluded that the approach of mixed solvency concept is novel, safe, cost-effective and user friendly. It also eliminates the problem of toxicity associated with high concentration of water-soluble solubilizers. So, it may be employed in dosage form development of drugs with poor solubility to overcome bioavailability issues. Keywords: Solubility, metronidazole, vaginal films, mixed solvency concept.

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“…The solubilities of a large number of poorly water soluble drugs have been enhanced by the mixed solvency concept. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] Also, use of multiple solubilizers reduces the amount of individual solubilizers, rendering it towards their safe use. Moreover, it also emerges as a tool to increase the drug loading in the same solvent, earlier having less room for drug and skipping the use of alternate solvent which is more likely of organic nature.…”

Section: Figure 1: Molecular Level Diagrammentioning

confidence: 99%

Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation

Agrawal¹,

Maheshwari²

2018

J. Drug Delivery Ther.

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Application of mixed solvency has been employed in the present research work to develop a liquisolid system (Powder formulation) of poorly water soluble drug, cefixime (as model drug). Material and Methods: For poorly water soluble drug cefixime, combination of solubilizers such as sodium acetate, sodium caprylate and propylene glycol as mixed solvent systems were used to decrease the overall concentration of solubilizers required to produce substantial increase in solubility and thereby resulting in enhanced drug loading capacity of cefixime. The procured sample of cefixime was characterized by melting point, IR, UV and DSC studies. Stability studies of liquisolid system of cefixime were performed for two months at room temperature, 30˚C and 40˚C. All the formulations were physically, chemically, and microbiologically stable. Conclusion: Mixed solvency concept has been successfully employed for enhancing the drug loading of poorly water soluble drug, cefixime. Keywords: Solubility, cefixime, liquisolid system, mixed solvency concept.

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Solid as solvent-Novel Spectrophotometric Analytical Method for Metronidazole Tablets using Solids (Eutectic Liquid of Phenol and Niacinamide) as Solubilizing Agents (Mixed Solvency Concept)

Cited by 5 publications

References 0 publications

Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

Formulation and development of vaginal films of poorly water soluble drug, metronidazole, using mixed solvency concept and their evaluations

Novel application of mixed solvency concept in the development of oral liquisolid system of a poorly soluble drug, cefixime and its evaluation

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