Solenopsis geminata (tropical fire ant) anaphylaxis among Thai patients: its allergens and specific IgE-reactivity

doi:10.12932/ap-100217-0012

Cited by 7 publications

(6 citation statements)

References 17 publications

(22 reference statements)

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“…78 In Thailand, commercially available S. invicta whole body extract (WBE) VIT has been employed as a treatment for allergy to S. geminata , which exhibits cross-reactivity on allergen testing. 34 In a case series of children, 4 of 14 (29%) VIT-treated children still reacted to further stings. After doubling the standard dose, all children were protected.…”

Section: Formicidaementioning

confidence: 98%

“…32 Severe allergic reactions have been estimated in approximately 2% of patients seeking medical care for ant stings and, as of 1989, over 84 fatal cases had been reported in the US. 33 Solenopsis species are also an important cause of allergy in Asia 34 and South America perhaps exacerbated by deforestation. 32 Pogonomyrmex , a species native to the US & Mexico, is thought to have the most painful sting of North-American ants, and the most toxic of all insect venoms based on median lethal dose in mice.…”

Section: Subfamily Myrmicinaementioning

confidence: 99%

See 1 more Smart Citation

Allergy to stings and bites from rare or locally important arthropods: worldwide distribution, available diagnostics, and treatment

Arzt‐Gradwohl

Sturm

Boni

et al. 2023

Preprint

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Insect venom allergy is the most frequent cause of anaphylaxis in Europe and possibly worldwide. The majority of systemic allergic reactions after insect stings are caused by Hymenoptera and among these, vespid genera induce most of the systemic sting reactions (SSR). Honey bees are the second leading cause of SSR. Depending on the global region, other Hymenoptera such as different ant genera are responsible for SSR. Widely distributed hornets and bumblebees or local vespid or bee genera rarely induce SSR. Hematophagous insects such as mosquitoes and horse flies usually cause (large) local reactions while SSR occasionally occur. This position paper aims to identify either rare or locally important insects causing SSR as well as rarely occurring SSR after stings or bites of widely distributed insects. We summarized relevant venom or saliva allergens and intended to identify possible cross-reactivities between the insect allergens. Moreover, we aimed to locate diagnostic tests for research and routine diagnosis, which are sometimes only regionally available. Finally, we gathered information on disposable immunotherapies. Major allergens of most insects were identified, and cross-reactivity between insects was frequently observed. While some diagnostics and immunotherapies are locally available, standardized skin tests and immunotherapies are generally lacking in rare insect allergy.

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Section: Formicidaementioning

confidence: 98%

Section: Subfamily Myrmicinaementioning

confidence: 99%

Allergy to stings and bites from rare or locally important arthropods: worldwide distribution, available diagnostics, and treatment

Arzt‐Gradwohl

Sturm

Boni

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…For instance, Technomyrmex albipes can adapt to a variety of habitats from urban to forests which harbor the native species, which can enable this species to possibly outcompete other species. Solenopsis geminata is an exotic venomous ant species in Thailand, causing serious reactions in hypersensitive people by anaphylaxis that accounts for more than 30% of the Thai ant allergic patients (Potiwat et al 2018). Cases of stings by this ant have been frequently reported on many Asian islands, including those in Indonesia and Taiwan (Hoffman 2010).…”

Section: Polyrhachis Sumatrensis Hamulatamentioning

confidence: 99%

An updated checklist of the ants of Thailand (Hymenoptera, Formicidae)

Khachonpisitsak¹,

Yamane²,

Sriwichai³

et al. 2020

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Thailand has a great diversity of ant fauna as a zoogeographical crossroads and biodiversity hotspot. The last publication presenting a Thai ant checklist was published in 2005. In the present paper, based on an examination of museum specimens and published records, a comprehensive and critical species list of Thai ants is synthesized. Currently, 529 valid species and subspecies in 109 genera among ten subfamilies are known from Thailand with their diversity and distribution within 77 provinces presented and assigned to six geographical regions. Furthermore, Thailand is the type locality for 81 ant species. Forty-one species are here newly recorded for Thailand with photographs illustrating these species. The checklist provides information on distribution and a comprehensive bibliography. This study will also serve as a guide for the upper northeast and central Thailand, which are poorly sampled; a comprehensive reference list relating to endemic taxa and localities where conservation is an important priority, thus an essential resource for policy makers and conservation planners concerned with the management of insect diversity in Thailand; and a list of exotic ant species found in Thailand, which could possibly impact the ecological balance.

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“…Cross-reaction within Solenopsis spp. was reported, indicating that the whole venom extract of S. geminata can yield positive results when detecting S. invicta -specific IgE from patients' sera 24 . There is no report on the phenomenon of cross-reactivity between Solenopsis spp.…”

Section: Introductionmentioning

confidence: 97%

Structure-based epitope prediction and assessment of cross-reactivity of Myrmecia pilosula venom-specific IgE and recombinant Sol g proteins (Solenopsis geminata)

Buraphaka,

Dobutr,

Wiese

et al. 2024

Sci Rep

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The global distribution of tropical fire ants (Solenopsis geminata) raises concerns about anaphylaxis and serious medical issues in numerous countries. This investigation focused on the cross-reactivity of allergen-specific IgE antibodies between S. geminata and Myrmecia pilosula (Jack Jumper ant) venom proteins due to the potential emergence of cross-reactive allergies in the future. Antibody epitope analysis unveiled one predominant conformational epitope on Sol g 1.1 (PI score of 0.989), followed by Sol g 2.2, Sol g 4.1, and Sol g 3.1. Additionally, Pilosulin 1 showed high allergenic potential (PI score of 0.94), with Pilosulin 5a (PI score of 0.797) leading in B-cell epitopes. The sequence analysis indicated that Sol g 2.2 and Sol g 4.1 pose a high risk of cross-reactivity with Pilosulins 4.1a and 5a. Furthermore, the cross-reactivity of recombinant Sol g proteins with M. pilosula-specific IgE antibodies from 41 patients revealed high cross-reactivity for r-Sol g 3.1 (58.53%) and r-Sol g 4.1 (43.90%), followed by r-Sol g 2.2 (26.82%), and r-Sol g 1.1 (9.75%). Therefore, this study demonstrates cross-reactivity (85.36%) between S. geminata and M. pilosula, highlighting the allergenic risk. Understanding these reactions is vital for the prevention of severe allergic reactions, especially in individuals with pre-existing Jumper Jack ant allergy, informing future management strategies.

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Solenopsis geminata (tropical fire ant) anaphylaxis among Thai patients: its allergens and specific IgE-reactivity

Abstract: S. geminata is identified as the most common causative ant anaphylaxis in Thai patients. Its WBE comprises of 13 IgE-binding components and 3 major allergens (26, 55 and 75 kDa), which supported possible IgE-mediated mechanism.

Cited by 7 publications

References 17 publications

Allergy to stings and bites from rare or locally important arthropods: worldwide distribution, available diagnostics, and treatment

Allergy to stings and bites from rare or locally important arthropods: worldwide distribution, available diagnostics, and treatment

An updated checklist of the ants of Thailand (Hymenoptera, Formicidae)

Structure-based epitope prediction and assessment of cross-reactivity of Myrmecia pilosula venom-specific IgE and recombinant Sol g proteins (Solenopsis geminata)

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