Sole-amorphous-sugar-based solid dispersion of curcumin and the influence of formulation composition and heat treatment on the dissolution of curcumin

Sekitoh, Takanari; Okamoto, Takashi; Fujioka, Akiho; Tramis, Olivier; Takeda, Koji; Matsuura, Tsutashi; Imanaka, Hiroyuki; Ishida, Naoyuki; Imamura, Koreyoshi

doi:10.1080/07373937.2020.1752711

Cited by 10 publications

(7 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SDs investigated in all of the studies [54][55][56] showed a T g below 40 • C, indicating the potential vulnerability of these systems to instability during storage and solutionmediated phase transitions during the drug dissolution process. This phenomenon was unequivocally substantiated with dissolution studies, where a distinctive "spring and parachute" effect was consistently observed across these investigations.…”

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 93%

“…This phenomenon was unequivocally substantiated with dissolution studies, where a distinctive "spring and parachute" effect was consistently observed across these investigations. Furthermore, it was noted that the T g of these systems decreased with an increase in the drug content, attributable to the plasticizing effect of the hydrophobic drug [56]. The decrease in the T g of the SDs directly relates to the T g of the pure sugars [55,56].…”

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 99%

“…This technique exhibits great promise, as it allows for the solubilization of substantial quantities of sugars, up to 100 mg/mL, in methanol [53]. Subsequently, the resultant mixture is further processed via vacuum-drying [54][55][56] to remove the organic solvent. The resultant material showed no discernible endothermic events during DSC analysis, indicating the conversion of both components into an amorphous form, thereby yielding ASDs.…”

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 99%

“…Furthermore, it was noted that the T g of these systems decreased with an increase in the drug content, attributable to the plasticizing effect of the hydrophobic drug [56]. The decrease in the T g of the SDs directly relates to the T g of the pure sugars [55,56]. However, when the SAS-SDs are subjected to thermal treatments above the melting point of the drug followed by rapid cooling (quenching), a distinctive plateau emerges in the subsequent drug dissolution profile [56].…”

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 99%

See 3 more Smart Citations

Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

Poka,

Milne,

Wessels

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Crystalline carriers such as dextrose, sucrose, galactose, mannitol, sorbitol, and isomalt have been reported to increase the solubility, and dissolution rates of poorly soluble drugs when employed as carriers in solid dispersions (SDs). However, synthetic polymers dominate the preparation of drugs: excipient SDs have been created in recent years, but these polymer-based SDs exhibit the major drawback of recrystallisation upon storage. Also, the use of high-molecular-weight polymers with increased chain lengths brings forth problems such as increased viscosity and unnecessary bulkiness in the resulting dosage form. An ideal SD carrier should be hydrophilic, non-hygroscopic, have high hydrogen-bonding propensity, have a high glass transition temperature (Tg), and be safe to use. This review discusses sugars and polyols as suitable carriers for SDs, as they possess several ideal characteristics. Recently, the use of low-molecular-weight excipients has gained much interest in developing SDs. However, there are limited options available for safe, low molecular excipients, which opens the door again for sugars and polyols. The major points of this review focus on the successes and failures of employing sugars and polyols in the preparation of SDs in the past, recent advances, and potential future applications for the solubility enhancement of poorly water-soluble drugs.

show abstract

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 93%

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 99%

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 99%

Section: Solid Dispersions Of Sugar Carriersmentioning

confidence: 99%

See 2 more Smart Citations

Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

Poka,

Milne,

Wessels

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…The supersaturation generation results in a high kinetic drug solubility, which is multifold higher than the thermodynamic solubil-ity exhibited by the stable crystalline form [12]. Various amorphous CUR formulations exhibiting enhanced CUR solubility have been developed in the form of amorphous solid dispersion [13][14][15], co-amorphous system [16][17][18], and amorphous nanoparticles [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

Lim

Hadinoto

2021

IJMS

View full text Add to dashboard Cite

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR’s poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR–chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films’ characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.

show abstract

Foaming characteristics of sugar- and polyvinylpyrrolidone-alcohol solutions during vacuum foam drying: A rheological approach

Tramis

Fujioka

Imanaka

et al. 2021

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

Sole-amorphous-sugar-based solid dispersion of curcumin and the influence of formulation composition and heat treatment on the dissolution of curcumin

Cited by 10 publications

References 52 publications

Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

Sugars and Polyols of Natural Origin as Carriers for Solubility and Dissolution Enhancement

High-Payload Buccal Delivery System of Amorphous Curcumin–Chitosan Nanoparticle Complex in Hydroxypropyl Methylcellulose and Starch Films

Foaming characteristics of sugar- and polyvinylpyrrolidone-alcohol solutions during vacuum foam drying: A rheological approach

Contact Info

Product

Resources

About