Solasodine: A Perspective on their roles in Health and Disease

Kumar, Rahul; Khan, Mohammad Ibrahim; Prasad, Mahesh; Badruddeen, .

doi:10.5958/0974-360x.2019.00432.3

Cited by 12 publications

(10 citation statements)

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“…The LC–MS investigation of F. cirrhosa bulb extracts revealed the presence of 88 phytochemical compounds, which could contribute to the medicinal properties of this plant species 14 . Solasodine (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)5',7,9,13tetramethylspiro[5oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-piperidine]-16-ol) were extracted from Solanum dulcamara and evaluated for antimicrobial activity against the test bacteria like Staphylococcus aureus , Enterobacter aerogenes , Escherichia coli 45 , 46 . Linarin (5-hydroxy-2-(4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one) a bioactive flavone glycoside has been characterized abundantly in the Cirsium , Micromeria , and Buddleja species and exhibited promising activities particularly, the remedial effects on central nervous system (CNS) disorders 47 .…”

Section: Discussionmentioning

confidence: 99%

Metabolite fingerprinting of phytoconstituents from Fritillaria cirrhosa D. Don and molecular docking analysis of bioactive peonidin with microbial drug target proteins

Bhat

Mir

Sheikh

et al. 2022

Sci Rep

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Fritillaria cirrhosa D. Don (Liliaceae), a valuable and critically endangered medicinal herb of northwest India, including Jammu and Kashmir, grows in temperate to alpine regions of the Himalaya. It is known as the traditional herb for cardiovascular diseases, respiratory diseases, and metabolic disorders. The plant bulbs are precious and are used to cure many other health complications. The current study analysed the phytoconstituents by liquid chromatography-mass spectrometry (LC–MS) of different crude extracts (methanolic, petroleum ether, and ethyl acetate) of F. cirrhosa. The LC–MS analysis from the bulbs of F. cirrhosa yielded 88 bioactive compounds, with the vast majority having therapeutic applications. Further, determination of minimum inhibitory concentrations (MICs) by broth microdilution method of F. cirrhosa against tested bacterial and fungal pathogens showed remarkable results with MICs ranging between 6.25–200 µg/mL and 50–400 µg/mL, respectively. Subsequently, these 88 identified phytocompounds were tested for their bioactivity through ADMET prediction by SwissADME and in silico molecular docking studies. Results revealed that Peonidin might have maximum antibacterial and antifungal activity against various microbial protein drug targets among the phytochemical compounds identified. Furthermore, the highest binding affinity complex was subjected to molecular dynamic simulation (MDS) analysis using Desmond Schrodinger v3.8. The root-mean-square deviation (RMSD) graphs obtained through the molecular dynamic simulations indicated the true bonding interactions, further validated using the root-mean-square fluctuation (RMSF) graphs which provided a better understanding of the amino acids present in the proteins responsible for the molecular motions and fluctuations. To our best knowledge, this is the first description of the phytochemical constituents of the bulbs of F.cirrhosa analyzed through LC–MS, which show pharmacological significance. The in silico molecular docking and molecular dynamics study of peonidin was also performed to confirm its broad-spectrum activities based on the binding interactions with the antibacterial and antifungal target proteins. The present study results will create a way for the invention of herbal medicines for several ailments by using F. cirrhosa plants, which may lead to the development of novel drugs.

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Section: Discussionmentioning

confidence: 99%

Metabolite fingerprinting of phytoconstituents from Fritillaria cirrhosa D. Don and molecular docking analysis of bioactive peonidin with microbial drug target proteins

Bhat

Mir

Sheikh

et al. 2022

Sci Rep

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“…Symptoms of glycoalkaloid poisoning in humans include colic pain in the abdomen and stomach, diarrhoea, vomiting, burning sensation about the lips and mouth, fever, rapid pulse and headache (Uluwaduge et al 2018;Deng et al 2021). Other destructive effects of glycoalkaloids include craniofacial malformations in hamsters (Gaffield and Keeler 1996;Ni et al 2018;Kumar et al 2019) and a variety of organ malformations in frog embryos and mealworms (Friedman et al 1991;Chen et al 2021). Furthermore, the Centre for Food Safety (2015) reported on poisoning of patients after consumption of cooked potatoes, and subsequent investigations revealed that the poisoning was due to the glycoalkaloid α-solanine.…”

Section: Highlightsmentioning

confidence: 99%

Effect of Microwave-Assisted Aqueous Two-Phase Extraction of α-Solanine from S. retroflexum and Analysis on UHPLC-qTOF-MS

et al. 2022

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A new, fast and efficient method, hyphenated microwave-assisted aqueous two-phase extraction (MA-ATPE) was applied in the extraction of α-solanine from Solanum retroflexum. This environmentally friendly extraction method applied water and ethanol as extraction solvents. Central composite design (CCD) was performed which included numerical parameters such as time, mass of plant powder and microwave power. The categorical factors included the chaotrope — NaCl or the kosmotrope — Na2CO3. Fitting the central composite design response surface model to the data generated a quadratic model with a good fit (R2 = 0.920). The statistically significant (p < 0.05) parameters such as time and mass of plant powder were influential in the extraction of α-solanine. Quantification of α-solanine was achieved using a robust and sensitive feature of the ultra-high performance quadrupole time of flight mass spectrometer (UHPLC-qTOF-MS), multiple reaction monitoring (MRM). The optimized condition for the extraction of α-solanine in the presence of NaCl and Na2CO3 was a period of 1 min at a mass of 1.2 g using a microwave power of 40%. Maximal extraction of α-solanine was 93.50 mg kg−1 and 72.16 mg kg−1 for Na2CO3 and NaCl, respectively. The synergistic effect of salting-out and microwave extraction was influential in extraction of α-solanine. Furthermore, the higher negative charge density of the kosmotrope (Na2CO3) was responsible for its greater extraction of α-solanine than chaotrope (NaCl). The shorter optimal extraction times of MA-ATPE make it a potential technique that could meet market demand as it is a quick, green and efficient method for removal of toxic metabolites in nutraceuticals.

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“…La solasodina se ha descrito en numerosas especies de la familia Solanaceae, es un glicoalcaloide del tipo esteroidal, al igual que la solamargina. La solasodina, al igual que las especies que la sin-tetizan, son muy valoradas por sus aptitudes farmacológicas, ya que las mismas son empleadas para la producción de corticoesteroides, esteroides anabólicos y drogas con efectos antifertilidad, también se le atribuye varias acciones tales como anticonvulsivo, antioxidante, antiinflamatorio, hepatoprotector, inmunomodulador, antimicrobiano, entre otras actividades (Kumar et al, 2019;Mann, 1979).…”

Section: Montrieux Et Al (2014) Emplearon Al áCido Rosmarínico Y Al á...unclassified

Análisis estructural de interacciones in silico de fitoconstituyentes de Solanum americanum, Solanum guaraniticum y Solanum lycopersicum con la proteína tripanotiona reductasa de Leishmania infantum

Gayozo

Rojas

2020

Steviana

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Solasodine: A Perspective on their roles in Health and Disease

Cited by 12 publications

References 0 publications

Metabolite fingerprinting of phytoconstituents from Fritillaria cirrhosa D. Don and molecular docking analysis of bioactive peonidin with microbial drug target proteins

Metabolite fingerprinting of phytoconstituents from Fritillaria cirrhosa D. Don and molecular docking analysis of bioactive peonidin with microbial drug target proteins

Effect of Microwave-Assisted Aqueous Two-Phase Extraction of α-Solanine from S. retroflexum and Analysis on UHPLC-qTOF-MS

Análisis estructural de interacciones in silico de fitoconstituyentes de Solanum americanum, Solanum guaraniticum y Solanum lycopersicum con la proteína tripanotiona reductasa de Leishmania infantum

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