In-situ observations of the solar wind (SW) plasma from 0.29 to 1AU show that the protons and α particles are often non-Maxwellian, with evidence of kinetic instabilities, temperature anisotropies, differential ion streaming, and associated magnetic fluctuations spectra. The kinetic instabilities in the SW multi-ion plasma can lead to preferential heating of α particles and the dissipation of magnetic fluctuation energy, affecting the kinetic and global properties of the SW. Using for the first time a three-dimensional hybrid model, where ions are modeled as particle using the Particle-In-Cell (PIC) method and electrons are treated as fluid, we study the onset, nonlinear evolution and dissipation of ion kinetic instabilities. The Alfvén/ion-cyclotron, and the ion drift instabilities are modeled in the region close to the Sun (∼ 10R s ). Solar wind expansion is incorporated in the model. The model produces self-consistent non-Maxwellian velocity distribution functions (VDFs) of unstable ion populations, the associated temperature anisotropies, and wave spectra for several typical SW instability cases in the nonlinear growth and saturation stage of the instabilities. The 3D hybrid modeling of the multi-ion SW plasma could be used to study the SW acceleration region close to the Sun that will be explored by the Parker Solar Probe mission.Ofman is usually hotter than that of the proton population, and flows faster by an Alfvén speed in the fast SW streams. The VDFs of protons and ions exhibit non-Maxwellian features, such as temperature anisotropy with respect to the background magnetic field, beams (with stronger departures from Maxwellian for the α particles), and differential ion streaming (Marsch et al., 1982). These effects are stronger in the fast SW streams (compared to slow SW), increasing in magnitude closer to the Sun. Kinetic instabilities, such as ion-cyclotron, mirror and firehose, play an important role in shaping the SW plasma properties, as evident from observations at 1AU with WIND (Bale et al., 2009;Maruca, Kasper, and Gary, 2012) and other spacecraft data.Observed break points in the magnetic fluctuations power spectra indicate the inertial and kinetic dissipation ranges of magnetic field fluctuations (see the review, Bruno and Carbone, 2013), with the break point of the dissipation range aligned with the proton cyclotron frequencies at the various heliocentric distances (e.g., Bourouaine et al., 2012;Telloni, Bruno, and Trenchi, 2015). Direct evidence of electromagnetic ion cyclotron (EMIC) waves near the proton cyclotron frequency was found in the SW by STEREO at 1AU (e.g., Jian et al., 2009Jian et al., , 2014 and from Helios and MESSENGER at 0.3 AU (Jian et al., 2010). Preferential acceleration and heating of the α particle populations was associated with wave activity in Durovcová, Němeček, andŠafránková, 2019).Recently launched NASA's Parker Solar Probe (PSP) mission, is going to provide detailed in-situ observations as close as 10R s , aimed at studying the SW acceleration and heating proces...