Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis

Wu, Qiyun; Xia, Yiteng; Dai, Kun; Bai, Panzhu; Kwan, Kenneth Kin Leung; Guo, Maggie Suisui; Dong, Tina Ting Xia; Tsim, Karl Wah Keung

doi:10.1096/fj.202000708r

Cited by 15 publications

(38 citation statements)

References 67 publications

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“…However, in vitiligo, both the impairment of melanocytes and the morphology and function of keratinocytes exist. The interaction between keratinocytes and melanocytes plays an important role in maintaining the homeostasis of the epidermis 27 . Compared with normally pigmented epidermis, the apoptosis of keratinocytes is more likely to occur in depigmented suction‐blistered epidermis, which can decrease the levels of keratinocyte‐derived factors, such as SCF and basic fibroblast growth factor.…”

Section: Discussionmentioning

confidence: 99%

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Zhao

Wang

et al. 2020

J Cellular Molecular Medi

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Vitiligo is an acquired disfiguring dermatosis characterized by patchy depigmentation due to the selective loss of functioning melanocytes. The incidence rate of vitiligo is approximately 0.5%-1.0% of the world's population. 1 At present, the aetiology of vitiligo remains unclear. Multiple studies demonstrated that massive oxidative stress may lead to vitiligo. Oxidation pathway is regarded as the important steps in the development of vitiligo. 2 In human skin, each melanocyte forms an epidermal melanin unit with 36 keratinocytes, which play an important role in maintaining melanocyte homeostasis. 3 Various growth factors produced by keratinocytes affect melanocyte proliferation and differentiation, such as endothelin-1, stem cell factor and basic fibroblast growth factor. 4-6 Additionally, keratinocyte-derived soluble factors regulate the melanogenesis of neighbouring melanocytes. 7 Moreover, various hormonal and peptide factors produced

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Section: Discussionmentioning

confidence: 99%

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Zhao

Wang

et al. 2020

J Cellular Molecular Medi

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“…Several reports suggest the role of ACh, AChRs, and enzymes related to ACh metabolism in melanogenesis. That is, sunlight, for example, promotes the release of ACh from keratinocytes in the skin, and this increased ACh and AChE inhibitor also suppressed the increased melanogenesis by light [ 96 ]. These results suggest the possibility that ACh inhibits melanogenesis and the possibility that AChE may play an important role in the promotion of melanogenesis.…”

Section: Amines Neurotransmitters and Their Receptors In Skin Pigmentation Diseasesmentioning

confidence: 99%

Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication

Enkhtaivan

Lee

2021

IJMS

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Skin pigmentation can occur due to increased melanin, including melanocyte proliferation, melanin biosynthesis, or melanocyte migration. There are many factors that influence the melanin production process, but the role of neurotransmitters in this process is still unclear. We found that histamine and serotonin influence the different stages of melanogenesis and melanogenesis, which increase melanogenesis. Since then, several related papers have been published, and from these papers, it has been recognised that the role of neurotransmitters in skin-pigment-related diseases needs to be summarised. By introducing the role of neurotransmitters in the regulation of various pigment disorders, including vitiligo and melasma, through this review, many researchers can be expected to try to apply neurotransmitter-related agonists and antagonists as treatments for skin pigment disorders.

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“…ACh binds to the acetylcholine receptor (AChR) and acetylcholinesterase (AChE) of melanocytes, resulting in the inhibition of the cAMP-dependent signaling pathway. Melanogenesis caused by solar light in melanocytes is suppressed by ACh and AChE inhibitors, indicating that the cholinergic mechanism plays a part in inhibiting melanogenesis [12,13].…”

Section: Acetylcholine Signaling Pathwaymentioning

confidence: 99%

Development of Pigmentation-Regulating Agents by Drug Repositioning

Jeong

Yoon

2021

IJMS

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Skin color is determined by the processes of melanin synthesis and distribution. Problems in various molecules or signaling pathways involved in melanin synthesis contribute to skin pigmentation defects. Several trials have been conducted on the production of pigmentation-regulating agents, and drug repositioning has emerged as a modern technique to identify new uses for existing drugs. Our research team has researched substances or drugs associated with pigmentation control and, as a result, nilotinib, sorafenib, and ICG-001 have been found to promote pigmentation, while 5-iodotubercidin inhibits pigmentation. Therefore, these substances or medications were suggested as potential therapeutics for pigmentation disorders by drug repositioning.

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Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis

Cited by 15 publications

References 67 publications

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Down‐regulation of exosomal miR‐200c derived from keratinocytes in vitiligo lesions suppresses melanogenesis

Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication

Development of Pigmentation-Regulating Agents by Drug Repositioning

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