Solar Cheilitis

Cataldo, E; Doku, H.Chris

doi:10.1111/j.1524-4725.1981.tb00203.x

Cited by 53 publications

(60 citation statements)

References 15 publications

(16 reference statements)

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“…O perfil demográfico clássico de pacientes com alto risco de QA, relatado na literatura, é de homens com mais de 50 anos de idade, pele clara e com elevado tempo de exposição solar 3,5,6,13,20,24 . Os resultados do presente estudo estão de acordo com este perfil de pacientes.…”

Section: Discussionunclassified

Queilite actínica: avaliação histopatológica de 44 casos

Arnaud

Soares

Paiva

et al. 2014

Rev. odontol. UNESP

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ResumoObjetivo: Descrever os aspectos epidemiológicos, clínicos e histopatológicos da queilite actínica. Material e método: Foi realizado um estudo retrospectivo a partir de casos com diagnóstico clínico de queilite actínica, registrados no arquivo histopatológico do Serviço de Cirurgia de Cabeça e Pescoço do Hospital Napoleão Laureano, Paraíba, relativos ao período de 2000 a 2007. Foram selecionados 44 blocos parafinados, que apresentavam condições de reavaliação histológica através da confecção de novas lâminas. Os novos cortes foram corados em Hematoxilina e Eosina, e a avaliação histopatológica foi realizada por dois examinadores independentes, sendo as alterações classificadas de acordo com OMS. Realizou-se análise estatística descritiva em programa SPSS for Windows versão 13. Resultado: Do total da amostra, 52,3% (23) dos casos foram diagnosticados em homens e 47,7% (21) em mulheres, com idade variando de 27 a 92 anos. A maioria dos indivíduos (81,9%) tinha mais de 40 anos. Em relação às características histológicas, 68,2% (30) dos casos exibiram algum grau de displasia epitelial, sendo 36,3% (16) classificados como displasia leve, 20,4% (9) como displasia moderada e 11,3% (5), displasia severa. Em 15,9% (7), ocorreu carcinoma de células escamosas. No tecido epitelial de revestimento labial, os achados histológicos mais frequentes e identificados foram presença de degeneração hidrópica (79,5%) e hipergranulose (56,8%). Infiltrado inflamatório foi observado em 88,6% dos casos e elastose solar, em 86,4%. Conclusão: Com base nos resultados da amostra estudada, podemos concluir que a maioria das lesões de queilite actínica acometeu lábio inferior de homens, com mais de 40 anos de idade. A análise histopatológica revelou displasia e atipia celular, infiltrado inflamatório e presença de elastose solar, que são características comuns em lesões de QA.Descritores: Queilite; carcinoma de células escamosas; radiação solar; carcinogênese. AbstractObjective:To describe the epidemiological, clinical and histopathological aspects in actinic cheilitis. Material and method: We conducted a retrospective study from cases with clinical diagnosis of actinic cheilitis recorded in the histopathology of the Service of Head and Neck Napoleon Laureano Hospital, Paraíba, from 2000 to 2007. We selected 44 paraffin blocks to product new slides. These new sections were stained with hematoxylin and eosin, and histopathological evaluation was performed by two independent examiners, and the changes classified according to OMS. We conducted a descriptive statistical analysis in SPSS for Windows version 13. Result: Of the total sample, 52.3% (23) cases were diagnosed in men and 47.7% (21) in women aged from 27 to 92 years old. Most individuals (81.9%) were over 40 years old. Regarding the histologic features, 68.2% (30) of cases showed some degree of epithelial dysplasia, 36.3% (16) classified as mild dysplasia, 20.4% (9) moderate dysplasia and 11.3% (5) severe dysplasia. In 15.9% (7) cases, squamous cell carcinoma of lip was observed. In e...

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Section: Discussionunclassified

Queilite actínica: avaliação histopatológica de 44 casos

Arnaud

Soares

Paiva

et al. 2014

Rev. odontol. UNESP

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“…In 1981, other authors described AC as a malignant lesion capable of developing a malignant phenotype [8]. In other study one author also correlated cases of epithelial dysplasia and squamous cell carcinoma in a cohort of 41 patients [3].…”

Section: Discussionmentioning

confidence: 99%

“…Pericytes are cells that influence the stability of blood vessels, through extracellular matrix deposition and the activation or production of molecules that promote cell differentiation or endothelial quiescence [7,8]. Their biological role in dysplastic lesions, such as AC, remains to be elucidated.…”

mentioning

confidence: 99%

Immunohistochemical expression of pericytes and myofibroblasts in the extracellular matrix of oral actinic cheilitis and squamous cell carcinoma: a comparative study

Wanderley¹,

Nunes²,

Ferreira³

et al. 2017

Rev. Odonto Ciênc. (Online)

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OBJECTIVE: The aim of the present study is to conduct a comparative analysis of oral actinic cheilitis and squamous cell carcinomas by immunohistochemical analysis. METHODS: This cross-sectional study utilizes a convenience sample obtained from the archives of an oral pathology laboratory from a higher education institution. Tissue sections from patients diagnosed with actinic cheilitis and carcinoma were immunohistochemically analyzed using monoclonal antibodies specific for smooth muscle alpha actin (SMA) and neuron-glial antigen 2 (NG2). Individual cells that stained positive for these proteins were counted in specific fields by means of histomorphometry. RESUlTS: Subsequent statistical analysis revealed a higher number of NG2-positive when compared with SMA-positive cells in both lesion types (p = 0.005) and these cells were located adjacent to blood vessels. The differences between normal oral mucosa, severe dysplasia, and carcinoma specimens were statistically significant (p = 0.009; p = 0.006). CONClUSION: These data strongly suggest that increased expression of NG2-and SMA-positive cells is associated with formation of blood capillaries, highlighting the importance of angiogenesis in tumor progression.Key words: Carcinoma; Pericytes; Myofibroblasts Expressão imuno-histoquímica de pericitos e miofibroblastos na matriz extracelular de queilite actínica oral e carcinoma de células escamosas: estudo comparativo REsUMO OBJETIVO: O objetivo do presente estudo foi realizar uma análise comparativa da queilite actínica e do carcinoma de células escamosas por meio de análise imuno-histoquímica. MÉTODOS: Este estudo transversal utilizou uma amostra de conveniência obtida dos arquivos de um laboratório de patologia oral de uma instituição de ensino superior. As secções de tecido de pacientes diagnosticados com queiliteactínica e carcinoma foram analisados pela técnica imuno-histoquímica usando anticorpos monoclonais específicos para alfa actina de músculo liso (SMA) e do antígeno neurônio/glial2 (ng2). As células com marcação positiva para estas proteínas foram contadas em campos específicos por meio de histomorfometria. RESUlTADOS: análise estatística subsequente revelou maior número de positivos para ng2 quando comparados com células SMA positivas em ambos os tipos de lesão (p = 0,005) seno que estas células foram localizadas adjacentes aos vasos sanguíneos. As diferenças entre mucosa oral normal, displasia grave e espécimes de carcinoma foram estatisticamente significativas (p = 0,009; p = 0,006). CONClUSÃO: Os dados sugerem, fortemente, que o aumento da expressão de células positivas para ng2 e SMA está associado à formação de capilares sanguíneos, destacando a importância da angiogênese na progressão tumoral.

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“…The acute form is associated with episodes of intense sun exposure and is characterised by oedema, redness, fissures, ulcerations, and vesicles. This form is usually self-limited and disappears after the removal of causal agents [27]. The chronic form occurs due to continuous sun exposure, and all participants in this study exhibited the chronic form of AC.…”

Section: Discussionmentioning

confidence: 99%

Actinic Cheilitis: Clinical Characteristics Observed in 75 Patients and a Summary of the Literature of This Often Neglected Premalignant Disorder

Miranda¹,

Ferrari²,

Leite³

et al. 2014

IJCM

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Actinic cheilitis can progress to squamous cell carcinoma in 20% of cases. The purpose of this study was to identify the clinical characteristics of 75 patients with actinic cheilitis and to summarise the current literature concerning actinic cheilitis. A total of 75 patients were evaluated over a 3-year period. The medical history, physical examination results and images were collected from each patient. Demographic data were collected and analysed. To review the literature, the relevant data were collected from scientific journals in the last 30 years. The mean age of the patients was 56 years old; 42 patients (56%) were female, and 66 patients (88%) were white. Nineteen (25.3%) patients reported at least one symptom, including pain, burning and itching. Sixty-five (86.7%) patients presented actinic cheilitis only in the lower lip. All of the patients reported sun exposure, and 44 (58.6%) patients were exposed for more than 10 years. The main clinical aspects investigated and analysed included dryness (100%), flaking (72%) and white lesions (57.3%). Lip assessment is extremely important in medical and dental care. From the 15 lesions assessed in the presence of actinic cheilitis, the most common clinical characteristics observed were dryness, flaking and white lesions. It is imperative to know the clinical aspects that may be encountered in actinic cheilitis in order to achieve early diagnosis, thus avoiding lip squamous cell carcinoma transformation.

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Solar Cheilitis

Cited by 53 publications

References 15 publications

Queilite actínica: avaliação histopatológica de 44 casos

Queilite actínica: avaliação histopatológica de 44 casos

Immunohistochemical expression of pericytes and myofibroblasts in the extracellular matrix of oral actinic cheilitis and squamous cell carcinoma: a comparative study

Actinic Cheilitis: Clinical Characteristics Observed in 75 Patients and a Summary of the Literature of This Often Neglected Premalignant Disorder

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