Solanine reverses multidrug resistance in human myelogenous leukemia K562/ADM cells by downregulating MRP1 expression

Yi, Ying‐Jie; Xing, Jia; Zhu, Cong; Wang, Jian‐Yong; Chen, Jie‐Ru; Wang, Hong; Li, Youjie

doi:10.3892/ol.2018.8563

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…Solanine also inhibits the proliferation of human prostate cancer xenografts in nude mice by significantly inhibiting the mRNA and protein expression of cyclin D1, cyclin E1, cyclin dependent kinase 2 (CDK2), CDK4 and CDK6 in vivo ( 11 , 12 ). A number of studies have confirmed that solanine has strong anti-cell proliferation effects on leukemia ( 13 , 14 ), endometrial cancer ( 15 ), liver cancer ( 16 , 17 ), esophageal cancer ( 18 ), pancreatic cancer ( 19 ) and so on ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, studies have pointed out that the growth arrest specific 5 (GAS5)/miR-18a axis is another important mechanism promoting the radiosensitivity of prostate cells ( 12 ). In the study of leukemia, solanine increases the chemical sensitivity of acute lymphocytic leukemia to doxorubicin, and reverses multidrug resistance in chronic myelogenous leukemia cells by downregulating multidrug resistance protein 1 (MRP1) expression ( 13 , 14 ).…”

Section: Discussionmentioning

confidence: 99%

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A narrative review of the antitumor studies of solanine

Luo¹,

Tian²,

Yu³

et al. 2021

Transl Cancer Res TCR

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Cancer is a major worldwide public health problem. With the popularity of medical examinations, the improvement of surgical procedures and the application of antitumor drugs, the mortality rate of cancer has declined in recent years, but the quantity remains extremely high. At the same time, with the emergence of tumor drug resistance, it is particularly urgent to seek new and effective drugs for tumor treatment. Solanine, a type of steroidal alkaloid, is the main extract of Solanum nigrum L. Because of its wide biological activity, it has attracted increasing attention, specifically, towards the empirical study of its antitumor activity. This article summarizes the research progress of the antitumor effect and mechanism of solanine over the past 20 years, to provide a reference for workers in the field of cancer research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A narrative review of the antitumor studies of solanine

Luo¹,

Tian²,

Yu³

et al. 2021

Transl Cancer Res TCR

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“…It increases the level of Bax and reduces Bcl-2 mRNA and protein levels. Furthermore, SN increases the chemosensitivity of these cells to adriamycin ( Yi et al, 2018a ) and reverses the multidrug resistance of human myelogenous leukemia (ML) K562/ADM cells ( Yi et al, 2018b ). Treatment with this compound reduces cell proliferation, leads to higher concentrations of adriamycin in cells, and reduces the expression of the MRP1 protein dependent on the JNK pathway ( Yi et al, 2018b ).…”

Section: Antitumor Effects Of Solanaceae Glycoalka...mentioning

confidence: 99%

Anticancer activity of glycoalkaloids from Solanum plants: A review

2022

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Cancer is still one of the main causes of death worldwide. For this reason, new compounds that have chemotherapeutic potential have been identified. One such group of substances is Solanaceae glycoalkaloids (GAs). They are natural compounds produced by plants widely used in traditional medicine for healing many disorders. Among others, GAs exhibit significant antitumor properties, for example, a strong inhibitory effect on cancer cell growth. This activity can result in the induction of tumor cell apoptosis, which can occur via different molecular pathways. The molecular mechanisms of the action of GAs are the subject of intensive research, as improved understanding could lead to the development of new cancer therapies. The genetic basis for the formation of neoplasms are mutations in protooncogenes, suppressors, and apoptosis-controlling and repair genes; therefore, substances with antineoplastic properties may affect the levels of their expression or the levels of their expression products. Therapeutic compounds can be applied separately or in combination with other drugs to increase the efficiency of cancer therapy; they can act on the cell through various mechanisms at different stages of carcinogenesis, inducing the process of apoptosis, blocking cell proliferation and migration, and inhibiting angiogenesis. This review summarizes the newest studies on the anticancer properties of solanine (SN), chaconine (CH), solasonine (SS), solamargine (SM), tomatine (TT) and their extracts from Solanum plants.

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“…For instance, emodin can reverse the drug resistance of K562 / ADM cells by inhibiting the expression of P -glycoprotein, which suggests that emodin is still potentially effective reversal agents in the treatment of chronic myeloid leukemia resistance [13]. solanine [14]and germacrone [15]were able to MDR. Through inhibiting the expression of P -glycoprotein and MRP, increasing the concentration of chemotherapeutic drugs in chronic myelogenous leukemia resistant cell lines and enhancing the cytotoxicity of drugs.…”

Section: Introductionmentioning

confidence: 99%

Exploring Molecular Mechanism of Traditional Chinese Medicine Euphorbiae Semen on Reversing of Multidrug Resistance in Leukemia Based on Network Pharmacology Strategy and Molecular Docking Technology

Song

Guo

Sun

et al. 2020

Preprint

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Background: Leukemia was listed by the World Health Organization as one of the five most intractable diseases in the world. The multi-drug resistance (MDR) of leukemia cells limits the efficacy of anti-tumor drugs and is the major reason for the chemotherapy failure and recurrence of leukemia chemotherapy. Some studies have shown that Euphorbiae semen (ES) possesses the characteristics of new therapeutic drugs for MDR. However, the molecular mechanisms and active compounds have not yet been fully clarified. Therefore, there is a need for explore its active compounds and demonstrate its mechanisms through network pharmacology and molecular docking technology.Method: First, the TCMSP database was searched and screened the active compounds of the ES, supplemented with compounds verified by literature, so as to further identify the core compounds in the active ingredient. Simultaneously, the TCMSP and Swiss database were searched to the targets of active compounds, and the targets of reverses leukemia multidrug resistance (RL-MDR) were screened in the relevant databases, such as GeneCards and DrugBank. Then, the targets of active compounds were intersected with RL-MDR targets to obtain potential targets of ES acting on MDR. The compound–target network was constructed by Cytoscape. The target protein–protein interaction network was built using STRING and Cytoscape database. Second, the R language and DAVID database were used to analyse Gene Ontology (GO) biological functions analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) signal pathways enrichment. Finally, molecular docking method was utilized to investigate the binding activity between the core targets and the active compounds of ES.Results: Compound–target network mainly contained 22 compounds and 81 corresponding targets. Finally, seven components in ES were selected and 10 core targets were identified; Key targets contained JUN, CASP3, MAOA, AR, PPARG, DRD2, ADRA2A, CHRM2, PTGS2 and MAPK14. GO enrichment analysis indicated the main biological functions of potential genes of ES in the treatment of MDR. KEGG pathway enrichment analysis showed the main pathways, mainly including apoptosis, pathways in cancer, p53 signaling pathway, VEGF signaling pathway, TNF signaling pathway and PI3K–Akt signaling pathway. Finally, we chose the top 10 common targets for molecular docking with the 7 active compounds of ES. The results of molecular docking indicated that the compounds of ES, which had good affinity with targets. Conclusion: The molecular mechanism of ES in the treatment of MDR showed the synergistic reaction of multi-compound, multi-target, and multi-pathway of traditional Chinese medicine, which provided ideas for further clinical research.

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Solanine reverses multidrug resistance in human myelogenous leukemia K562/ADM cells by downregulating MRP1 expression

Cited by 6 publications

References 37 publications

A narrative review of the antitumor studies of solanine

A narrative review of the antitumor studies of solanine

Anticancer activity of glycoalkaloids from Solanum plants: A review

Exploring Molecular Mechanism of Traditional Chinese Medicine Euphorbiae Semen on Reversing of Multidrug Resistance in Leukemia Based on Network Pharmacology Strategy and Molecular Docking Technology

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