Sol-gel derived bioactive glasses containing boron and strontium: Bioactivity, biocompatibility, and antibacterial properties

Niazvand, Firoozeh; Sharifianjazi, Fariborz; Esmaeilkhanian, AmirHossein; Ahmadi, Elahe; Moradigharibvand, Nahid; Rabiee, Navid; Seifalian, Alexander; Ghiasvand, Alireza; Hojjati, Mahsa

doi:10.1016/j.jnoncrysol.2024.122909

Cited by 4 publications

(1 citation statement)

References 61 publications

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“…After three standard deviations, the zones of inhibitions were measured. 47,48 Figure 10 represents the zone of inhibitions of the Li 2 O added borate glass network along with bargraphs. In generally, the borate glass network show a small portion of bioactivity, but in the presence of ZnO it may be increase.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial, Optical, Structural, and AC Conductivity Characteristics of Lithium-Doped Barium Zinc Borate Glasses for Multiple Applications

Anterbedy,

Pallati,

Seema

et al. 2024

ECS J. Solid State Sci. Technol.

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An Li2O-incorporated bioactive glass system of chemical composition xLi2O-10BaO-10ZnO-(80-x)B2O3 with x=0-20mol% was synthesized by melt-quench route. Non-crystalline behaviour was confirmed with X-ray diffraction spectra. The antibacterial zone of inhibitions increased with Li2O incorporation. Experimental densities increased with Li2O molar content and molar volume decreased. UV-Optical absorption spectra confirmed a cut-off wave length (λc) increasing trend by NBOs. Indirect band gap decreased, direct band gap decreased, and Urbach energy increased with Li2O addition. The refractive index of the glass system also increased. Fourier transform infrared and Raman spectroscopy studies confirmed the structural variations and existence of metal-oxides in the glass matrix. The AC conductivity increased with frequency, temperature, and also Li2O content by almost three orders of magnitude. The findings of higher order conductivity (10-3Ω-1cm-1), improvement in the zone of inhibitions upto 15 mm against E.Coli., and 14 mm against Salmonella; higher value of refractive index (n>2) confirms the multiple applications of these glasses.

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Section: Resultsmentioning

confidence: 99%

Antibacterial, Optical, Structural, and AC Conductivity Characteristics of Lithium-Doped Barium Zinc Borate Glasses for Multiple Applications

Anterbedy,

Pallati,

Seema

et al. 2024

ECS J. Solid State Sci. Technol.

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Simultaneously enhancing mechanical and tribological performance in undercooled Co-18.5 at. % B alloys

Ren,

Bu,

et al. 2024

Materials Chemistry and Physics

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Exploratory Investigation of Zinc-Modified Borosilicate Bioactive Glass: A New Methodology for Its Biocompatibility, Immunoregulation, and Pro-Angiogenic Property Evaluation

Zhang,

Huang,

et al. 2024

ACS Appl. Mater. Interfaces

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The assessment of biodegradable materials, such as bioactive glass, under the existing ISO 10993 standard test methods poses a significant challenge due to potential cell viability impairment caused by the accumulation of degraded products in a static environment. Therefore, innovative methodologies are urgently needed to tailor the unique biodegradation characteristics of these materials, providing more precise and scientific insights into biosafety and efficacy verification. Motivation by its bidirectional regulation of angiogenesis and immunity, zinc (Zn) was incorporated into sol−gel-derived borosilicate bioactive glasses (SBSGs) to fabricate Zn-incorporated borosilicate bioactive glasses (SBSG-Zn) to complement the tissue repair capabilities of bioactive glasses. Both SBSG and SBSG-Zn glasses consist of nanosized particles, slit mesoporous pores, high specific surface areas, and bioreactivity. In vitro comparative analysis, conducted according to ISO 10993 standards, demonstrates that only at suitable dilution rates�such as the 8-fold dilution employed in this study�do extracts of SBSG and SBSG-Zn glasses exhibit low cytotoxicity when cultured with human umbilical vein endothelial cells (HUVECs). Notably, SBSG-Zn glasses show optimal promotion of angiogenic gene expression in HUVECs. Furthermore, within an appropriate concentration range of released ions, SBSG-Zn glass extracts not only promote cell survival but also modulate the expression of anti-inflammatory genes while simultaneously inhibiting pro-inflammatory genes concurrently. After being implanted in rat subcutaneous defect models, both SBSG and SBSG-Zn glasses demonstrated the local immunoregulation and angiogenic effects. SBSG-Zn stands out by demonstrating superior modulation of M1/M2 polarization in macrophages as validated by altered secretion of key factors in macrophages and expression of relevant growth factors in HUVECs. These findings underscore the potential for convenient manipulation of localized angiogenic and immunoregulation through the incorporation of zinc into bioactive glass, emphasizing the importance of ensuring the appropriate ion doses are applied for achieving optimal therapeutic efficiency.

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Sol-gel derived bioactive glasses containing boron and strontium: Bioactivity, biocompatibility, and antibacterial properties

Cited by 4 publications

References 61 publications

Antibacterial, Optical, Structural, and AC Conductivity Characteristics of Lithium-Doped Barium Zinc Borate Glasses for Multiple Applications

Antibacterial, Optical, Structural, and AC Conductivity Characteristics of Lithium-Doped Barium Zinc Borate Glasses for Multiple Applications

Simultaneously enhancing mechanical and tribological performance in undercooled Co-18.5 at. % B alloys

Exploratory Investigation of Zinc-Modified Borosilicate Bioactive Glass: A New Methodology for Its Biocompatibility, Immunoregulation, and Pro-Angiogenic Property Evaluation

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