Sol–gel derived 45S5 bioglass: synthesis, microstructural evolution and thermal behaviour

Abstract

In this work, the 45S5 bioactive glass was synthesized through an aqueous sol-gel method. Characteristic functional groups were evidenced by Fourier transform infrared spectroscopy, the thermal behaviour was investigated by thermogravimetric and differential thermal analysis, crystallization kinetics and phase evolution were followed by X-ray diffraction measurements. The sintering behaviour of the sol-gel derived 45S5 was then studied by dilatometry and the microstructural evolution was followed step-by-step, interrupting the thermal cycle at different temperatures. In vitro dissolution tests were performed in order to assess the degradation behaviour of sol-gel derived 45S5 samples thermally treated at different temperatures. A relevant influence of the calcination conditions (namely, dwelling time and temperature) of the as-prepared powder on the phase appearance and its sintering behaviour as well as on the porosity features, in terms of pore dimension and interconnectivity, of the fired materials was stated.

Cationic and Anionic Substitutions in Hydroxyapatite

“…These substituted materials can be also seen not only as promising bone substitutes but also as drug delivery systems for the controlled-localized delivery, since the ions released during bone substitute resorption could be considered as drugs for bone disease treatment, being able to stimulate the expression of several osteoblastic cell genes [482,483], to induce angiogenesis in vitro and in vivo [484], and to exercise possible antibacterial [485] and inflammatory [486] actions, as evidenced in the case of ionic dissolution products from 45S5 Bioglass ® (e.g., Si, Ca, P, Na) and from other silicate-based glasses [487][488][489][490][491]. Thus it is very important to properly select both the ion doping amount, taking into account its therapeutic level and its release rate, and the ion kinds.…”

Exposure of the murine RAW 264.7 macrophage cell line to dicalcium silicate coating: assessment of cytotoxicity and pro-inflammatory effects

“…3a corresponds to dicalcium silicate [10], and the phase pattern seen in Fig. 3b corresponds to bioglass 45S5 [27]. The peaks have been labeled in the figures.…”

Preparation and in vitro characterization of electrospun 45S5 bioactive glass nanofibers

“…Silicate based glasses prepared by sol-gel processing have also been investigated for tissue engineering applications [15]. Recently, some sodium-containing bioactive glass-ceramic compositions including 45S5 Bioglass was synthesized by the sol-gel method [16][17][18]. Cacciotti et al [18] studied the synthesis and thermal behavior of 45S5.…”

“…Recently, some sodium-containing bioactive glass-ceramic compositions including 45S5 Bioglass was synthesized by the sol-gel method [16][17][18]. Cacciotti et al [18] studied the synthesis and thermal behavior of 45S5. Similarly, Pirayesh and Nychka synthesized the 45S5 using the sol-gel method followed by heat treatment to produce semi-crystalline structure and compared the bioactivity against amorphous melt cast 45S5 powder [16].…”