Two broad themes emerge from much of the literature on chemistry education over the last few decades. One: Students should be actively engaged. Two: Students learn more when they care about the topic. This article summarizes our efforts to use the environmental health effects of lead to engage students in authentic chemistry learning. We summarize and cite several related projects with similar goals to provide a resource for chemistry instructors interested in using the broad topic of human-lead interactions. Our work is relevant to environmental justice issues, and we suggest ways to introduce these topics into the chemistry classroom successfully.