Soil mutagenicity as a strategy to evaluate environmental and health risks in a contaminated area

Pohren, Roberta de Souza; Rocha, Jocelita Aparecida Vaz; Leal, Karen Alan; Vargas, Vera Maria Ferrão

doi:10.1016/j.envint.2012.01.008

Cited by 27 publications

(16 citation statements)

References 47 publications

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“…In addition, they are prone to adsorb to the organic particles of sediments and soil. Therefore, they are persistent and refractory in the environment (Pohren et al, 2012;Chen et al, 2014). Nowadays, PAHs have become a matter of concern due to their poisonousness, mutagenicity and carcinogenicity for humans (Kanaly and Harayama, 2000;Vila et al, 2001;Jin et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. ustb-1

et al. 2015

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Section: Introductionmentioning

confidence: 99%

An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. ustb-1

et al. 2015

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“…This ability of toxic metals to migrate from soil to groundwater have already been demonstrated, even in areas with past outbreaks of pollution (McBride et al 1997, Rattan et al 2005. Moreover, some metals present in soil samples and other complex mixtures have shown mutagenicity measured by Salmonella/microsome assay (Nestmann et al 1979, Mandel and Roser 1984, Pohren et al 2012.…”

Section: Discussionmentioning

confidence: 99%

“…USEPA points out that 95% of children ingest 200 mg/day of soil. Pohren et al (2012) used the value as a reference to estimate the mutagenic risk of exposure to soils at contaminated sites. In our study, except for the soil from the area of reference, the other soil samples presented the lowest V100% varying from 129.3-600.2 mg of soil.…”

Section: Discussionmentioning

confidence: 99%

Tools used to estimate soil quality in coal combustion waste areas

Júnior

Vargas

2014

An. Acad. Bras. Ciênc.

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Soil is a highly complex environmental compartment that has suffered with the contamination of substances of various origins. Among the main activities that affect soil quality are power generation activities that use fossil fuels, such as mineral coal. Environmental protection agencies encourage scientific investigations using tools described in legal devices or standard protocols to evaluate the potential of coal as a pollutant, especially in places that have large reserves of this mineral like the state of Rio Grande do Sul. The aim of this study was to characterize the leached extracts of different soils from an area influenced by coal waste, to classify them according to the guideline values for groundwater described in CONAMA's n. 420/2009, and to estimate the effects of the leachates ingestion in DNA mutation rates. The volume of soil needed to induce a 100% increase in the spontaneous mutation rate varied between 129.3 and 1544.1 mg of soil among the soils studied. Metals such as Mn, Pb, Cd and Ni surpassed the investigation limits for groundwater at least in one soil sample. The results showed that there can be transfer of soil contaminants to groundwater and soil intake in the area could contribute to the increased mutagenic risk.

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“…While operating, it used the following compounds as wood preservatives: pentachlorophenol (PCP) that can generate dioxins; creosote, formed by polycyclic aromatic hydrocarbons (PAHs); and chrome copper arsenate (CCA), with high toxic, genotoxic and carcinogenic potentials [Appel et al, ]. Among the studies already performed in this area, PAHs, PCP, dioxins and heavy metals were detected in soil and house dust samples associated with the presence of mutagenic and cytotoxic activity measured by the Salmonella /microsome assay [FEPAM, ; Pohren et al, ; Coronas et al, ]. It was also possible to define the routes of these contaminants from the soil to the main river, using the same chemical markers (chemical groups of compounds present in the wood preservatives) detected in this drained material in association with the Salmonella /microsome assay [Costa et al, ].…”

Section: Introductionmentioning

confidence: 99%

Assessment of sediment mutagenicity in areas under the influence of a contaminated site undergoing a remediation process

Gameiro

Pereira

Rocha

et al. 2018

Environ and Mol Mutagen

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Soil contamination enters aquatic ecosystems affecting sediment quality. The region studied is the Taquari River, Brazil, close to a site contaminated by wood preservatives, with a runoff route into the river. The first stage of the remediation process (In this article, the terms intervention and remediation have been used with slightly different meanings. We consider intervention to be the first phase of the remediation process, which aims to remove active sources) was an intervention to remove the main active sources. The Salmonella/microsome assay and polycyclic aromatic hydrocarbons (PAHs) were used to assess sediment quality in organic extracts during different intervention phases. The strains used were TA98, TA97a, and TA100 with and without S9mix (±S9). The results indicated the presence of pro-mutagens at site Ta010 (closest to the contaminated site) in all samplings, and the highest result occurred before intervention for TA100 + S9 (1,672 ± 215.9 rev/g). These values decreased during (83 ± 23.6 rev/g) and after this process (403 ± 105.9 rev/g), although the PAHs concentrations increased. Samples from this site presented PAHs with a carcinogenic potential during the assessed periods. After intervention, Ta006 (4 km downstream from Ta010) showed the most significant mutagenesis for TA100 + S9 (764 ± 230.2 rev/g) and, although the total PAHs values were lower, the species considered carcinogenic had higher concentrations. Mutagenesis predicted values of PAHs confirmed that carcinogenic species were predominantly detected by TA100, and the other PAHs by TA97a strains. Marked contaminant release to the river was observed, mainly in Ta010 at different periods. Mutagenicity and PAHs values in an internal stream, upstream from Ta010, showed a dispersion route of these agents. Thus, contamination in Ta010 and possible contribution to Ta006, after intervention, provides a warning regarding environmental quality in the region. Environ. Mol. Mutagen. 59:625-638, 2018. © 2018 Wiley Periodicals, Inc.

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Soil mutagenicity as a strategy to evaluate environmental and health risks in a contaminated area

Cited by 27 publications

References 47 publications

An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. ustb-1

An integrated approach of bioassay and molecular docking to study the dihydroxylation mechanism of pyrene by naphthalene dioxygenase in Rhodococcus sp. ustb-1

Tools used to estimate soil quality in coal combustion waste areas

Assessment of sediment mutagenicity in areas under the influence of a contaminated site undergoing a remediation process

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