Revealing the characteristics of soil nutrient space and studying the variation characteristics of soil nutrient space can provide a reliable theoretical basis for the precise management of soil nutrients. The purpose of this paper is to study the spatial characteristics analysis and changes of cultivated soil based on GIS. A spatial database was established and kriging interpolation was analyzed. To study the characteristics of the spatial variation of soil nutrients in the M area, select the optimal theoretical model, and conduct a detailed theoretical analysis of the spatial variation of the soil in the study area on the basis of ArcGIS 10.2 data. The contents of soil organic matter, total nitrogen, alkali-hydrolyzed nitrogen, available phosphorus and available potassium were profoundly affected by external factors; under anisotropy, the spatial correlation of each nutrient content hardly increased. The soil nutrients are generally higher in the north and lower in the south, and higher in the west and lower in the east. The distribution trend of available potassium in the region is not obvious, and there are high-value areas under different landforms.