New available geological, geotechnical, and geophysical data and new acquired ambient-noise surveys allowed for a detailed characterization of the soils in the Vega Baja region, located in the Lower Segura River basin, SE of the Iberian Peninsula. Single-station measurements were carried out at 90 sites, mainly over the central area of the basin, checking reproducibility by repeating some measurements under different conditions, on different dates, and through different acquisition systems, following well established standard procedures. The detailed data processing and analysis of the new acquired ambient-noise records provided the identification of multiple peaks in some of the horizontal-to-vertical spectral ratio curves, representing different impedance contrasts at depth that were 1D modelled to characterize the Vega Baja soils in terms of resonant frequencies, average shear-wave velocity, thickness of the different soil units, depth to the engineering bedrock and depth to the rock units when the model includes it. The depth to the engineering bedrock is around 30 m in the central part of the region, reaching maximum values of about 50 m in the north and to the east. Maximum values of the shear-wave velocity averaged over the soil units are close to 200 m/s while that averaged in the top 30 m reach values around 300 m/s south of the river bank. Contour mapping and cross-sections of the obtained model parameters illustrate the soil characteristics over the region, providing relevant information for the generation of representative sets of seismic hazard scenarios at different probability levels in future studies for their application in risk mitigation and emergency planning in the Vega Baja.