SOI MOSFET with grounded body potential by using the silicon direct bonding (SDB) technology

Kang, Won-Gu; Kang, Sung-Won; Lyu, Jong-Son; Kang, Sang‐Won; Lee, Jin-Hyo

doi:10.1109/soi.1993.344574

Cited by 2 publications

(1 citation statement)

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“…Several studies showed an important role for TGF-β signaling pathway in cervical oncogenesis [111]. A particularly interesting biological characteristic associated with malignant progression of cervical epithelial cells is their progressive loss of responsiveness to TGF-β [112,113]. An array study showed that TGF-β was amplified and overexpressed more than 2-fold in the cervical cancer group relative to its transcription and expression in the normal group [114].…”

Section: Further Cancer Indicationsmentioning

confidence: 99%

Combination Therapy of Bispecific Protein of Anti-PD-L1 Fused with TGF- β Receptor in Cancer

Yang¹

2022

AII

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Transforming growth factor β (TGF-β) and programmed death-ligand 1 (PD-L1) initiate signaling pathways with complementary, nonredundant immunosuppressive functions in the tumor microenvironment (TME). In the TME, dysregulated TGF-β signaling suppresses antitumor immunity and promotes cancer fibrosis, epithelial-mesenchymal transition, and angiogenesis. Meanwhile, PD-L1 expression inactivates cytotoxic T cell function and restricts immunosurveillance in the TME. Anti-PD-L1 therapies have been approved for the treatment of various cancers, while TGF-β signaling in the TME is associated with resistance to anti-PD-L1 therapies. Here, we have reviewed the rationale of the TGF-β and PD-L1 pathways in cancer and discussed current strategies using combination therapies that block these pathways separately or approaches with dualtargeting agents that may block the pathways simultaneously. Importantly, according to current clinical results, we propose the developing strategy of combination treatment with two or more agents.

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