Software improvement for evaluation of laryngopharyngeal pH testing (Restech) – a comparison between DataView 3 and 4

Müller, Dolores T.; Schulte, Elena; Babic, Benjamin; Knepper, Laura; Fuchs, Claudia; Schröder, Wolfgang; Bruns, Christiane; Leers, Jessica M.; Fuchs, Hans

doi:10.4240/wjgs.v12.i5.236

Cited by 3 publications

(3 citation statements)

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“…Interestingly, we observed that most oropharyngeal reflux events occurred supine and nighttime. This supine/nighttime profile of LPR does not corroborate the typical LPR profile of patients without OSA at the oropharyngeal pH-monitoring [ 28 ] or hypopharyngeal impedance-pH monitoring (HEMII-pH) [ 13 , 19 , 29 ]. Indeed, LPR patients have commonly upright and daytime pharyngeal reflux events, while the supine/nighttime events represent a low proportion of the 24-h reflux events [ 13 , 19 , 28 , 29 ].…”

Section: Discussionmentioning

confidence: 73%

“…This supine/nighttime profile of LPR does not corroborate the typical LPR profile of patients without OSA at the oropharyngeal pH-monitoring [ 28 ] or hypopharyngeal impedance-pH monitoring (HEMII-pH) [ 13 , 19 , 29 ]. Indeed, LPR patients have commonly upright and daytime pharyngeal reflux events, while the supine/nighttime events represent a low proportion of the 24-h reflux events [ 13 , 19 , 28 , 29 ]. The higher BMI of OSA patients and the related higher risk of GERD [ 30 ], which is commonly associated with supine events, may support our observation.…”

Section: Discussionmentioning

confidence: 73%

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Association between oropharyngeal ph-monitoring, pepsin saliva concentration and degree of apnea–hypopnea index of obstructive sleep apnea

Bobin,

Lechien

2023

Journal of Otolaryngology - Head & Neck Surgery

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Objective To investigate the association between obstructive sleep apnea (OSA) and laryngopharyngeal reflux (LPR) through oropharyngeal pH-monitoring and pepsin saliva measurements. Design Prospective uncontrolled study. Methods Patients with sleep disturbances and reflux symptoms underwent polysomnography, 24-h oropharyngeal pH-monitoring and saliva pepsin collections. The prevalence of LPR was investigated in OSA patients according to oropharyngeal pH-monitoring and pepsin measurements. A correlation analysis was performed between pH-monitoring findings, pepsin saliva levels, reflux symptom score-12 (RSS-12), reflux sign assessment (RSA), Apnea–Hypopnea Index (AHI), Epworth Sleepiness Scale, Pichot and arousal findings. Results Thirty-seven patients completed the evaluations. LPR was detected in 34/37 (92%) and 29/34 (85%) patients at the oropharyngeal-pH monitoring and pepsin test, respectively. OSA was detected in 30 patients (81%). Among them, LPR was detected in 28/30 (93%) cases. Pharyngeal reflux events mainly occurred nighttime/supine in OSA patients. Both Ryan score and supine reflux time at pH < 6.5 were significantly associated with BMI and the RSA sub- and total scores (p < 0.02). Tongue-base hypertrophy score was positively associated with the number of micro-arousals (p = 0.027); the supine percent of pH < 6.5 (p = 0.030); morning (p = 0.030) and bedtime pepsin saliva measurements (p = 0.037). The bedtime pepsin saliva level was significantly associated with Ryan Score (p = 0.047); AHI (p = 0.017) and the sleep saturation < 90% time (p = 0.040). The saliva level of the morning pepsin was associated with a shortest paradoxical sleep phase (p = 0.013). Conclusion OSA patients may have high prevalence of pharyngeal reflux events at the oropharyngeal pH-monitoring and high pepsin saliva measurements. Oropharyngeal pH-monitoring should be useful for the correlation between reflux and sleep findings in OSA patients. Future large cohort controlled studies are needed to determine the prevalence of LPR in OSA and healthy individuals.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 73%

Association between oropharyngeal ph-monitoring, pepsin saliva concentration and degree of apnea–hypopnea index of obstructive sleep apnea

Bobin,

Lechien

2023

Journal of Otolaryngology - Head & Neck Surgery

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“…This present research using the University of Cologne Reflux model was needed and helped to better understand the different existing reflux scenarios as well as purely validate Restech in volume refluxers. In addition, one of our previous projects focused on the validation of the new software version DataView 4 for analysis of measured pH data with the Restech device, suggesting that improvements made to the new software version might increase quality of results and correlation with esophageal pH measurement[ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal function testing model using a new laryngopharyngeal pH probe (Restech) in patients after Ivor-Lewis esophagectomy

Babic¹,

Müller²,

Gebauer³

et al. 2021

WJGO

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BACKGROUND There is no established correlation between 24-h esophageal pH-metry (Eso-pH) and the new laryngopharyngeal pH-monitoring system (Restech) as only small case series exist. Eso-pH was not designed to detect laryngopharyngeal reflux (LPR) and Restech may detect LPR better. We have previously published a dataset using the two techniques in a large patient collective with gastroesophageal reflux disease. Anatomically, patients after esophagectomy were reported to represent an ideal human reflux model as no reflux barrier exists. AIM To use a human reflux model to examine our previously published correlation in these patients. METHODS Patients after Ivor Lewis esophagectomy underwent our routine follow-up program with surveillance endoscopies, computed tomography scans and further exams following surgery. Only patients with a complete check-up program and reflux symptoms were offered inclusion into this prospective study and evaluated using Restech and simultaneous Eso-pH. Subsequently, the relationship between the two techniques was evaluated RESULTS A total of 43 patients from May 2016 - November 2018 were included. All patients presented with mainly typical reflux symptoms such as heartburn (74%), regurgitation (84%), chest pain (58%), and dysphagia (47%). Extraesophageal symptoms such as cough, hoarseness, asthma symptoms, and globus sensation were also present. Esophageal 24-hour pH-metry was abnormal in 88% of patients with a mean DeMeester Score of 229.45 [range 26.4-319.5]. Restech evaluation was abnormal in 61% of cases in this highly selective patient cohort. All patients with abnormal supine LPR were also abnormal for supine esophageal reflux measured by conventional Eso-pH. CONCLUSION Patients following esophagectomy and reconstruction with gastric interposition can ideally serve as a human reflux model. Interestingly, laryngopharyngeal reflux phases occur mainly in the upright position. In this human volume-reflux model, results of simultaneous esophageal and laryngopharyngeal (Restech) pH-metry showed 100% correlation as being explicable by one of our reflux scenarios.

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Reflux Finding Score Using HD Video Chromoendoscopy: A Diagnostic Adjunct in Suspected Laryngopharyngeal Reflux?

et al. 2022

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Software improvement for evaluation of laryngopharyngeal pH testing (Restech) – a comparison between DataView 3 and 4

Cited by 3 publications

References 19 publications

Association between oropharyngeal ph-monitoring, pepsin saliva concentration and degree of apnea–hypopnea index of obstructive sleep apnea

Association between oropharyngeal ph-monitoring, pepsin saliva concentration and degree of apnea–hypopnea index of obstructive sleep apnea

Gastrointestinal function testing model using a new laryngopharyngeal pH probe (Restech) in patients after Ivor-Lewis esophagectomy

Reflux Finding Score Using HD Video Chromoendoscopy: A Diagnostic Adjunct in Suspected Laryngopharyngeal Reflux?

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