Soft Tissue Special Issue: Imaging of Bone and Soft Tissue Sarcomas in the Head and Neck

Tran, Ngoc‐Anh; Guenette, Jeffrey P.; Jagannathan, Jyothi P.

doi:10.1007/s12105-019-01102-5

Cited by 8 publications

(3 citation statements)

References 38 publications

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“…Clinical and imaging findings are helpful in cases of small tumors with equivocal pathological findings. 6 Giant tumors as the case mentioned above are typically malignant and present no doubts.…”

Section: Discussionmentioning

confidence: 98%

Giant Soft Tissue Sarcoma of Scalp with Skull and Cerebral Invasion

Yelamanchi¹,

Manjunath

Gupta

et al. 2021

Nep. Med. Coll. J.

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Scalp soft tissue sarcomas (STS) are very rare accounting for less than 0.1% of all malignancies. We report a rare clinical image of advanced stage soft tissue sarcoma of the scalp. A 65 year woman had presented to the surgical department with complaints of a rapidly growing swelling over the scalp for three months. On examination there was huge 20 x 20 cm swelling over the scalp in the left temporoparietal region with variegated consistency. Computed tomography of head revealed a large soft tissue mass with necrosis invading the bone and underlying brain parenchyma. Histopathological finding from core needle biopsy revealed pleomorphic sarcoma. STS are highly malignant tumors which should be diagnosed and treated using multimodality approach. Recurrences are common even after complete resection and prognosis is poor.

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Section: Discussionmentioning

confidence: 98%

Giant Soft Tissue Sarcoma of Scalp with Skull and Cerebral Invasion

Yelamanchi¹,

Manjunath

Gupta

et al. 2021

Nep. Med. Coll. J.

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“…Imaging provides critical information for biopsy, surgical resection, chemotherapy or radiation. It plays an important role in the assessment of treatment response and disease recurrence [9]. Microscopically differentiating between this two entities propose a challenge and as a result of that, genetic analysis is necessary [10]: Lipoblastomas may have break-points in the long arm of chromosome 8 (8q 11-13) and liposarcomas typically show either the translocation t(12;16)(q13:p11) with the FUS/ TLS-CHOP chimeric fusión protein or the translocation t(12;22) (q13;q12) with the EWS-CHOP chimeric fusion protein [11].…”

Section: Discussionmentioning

confidence: 99%

"Neck Lipoblastoma. Differential Diagnosis of Cervical Mass in Children"

́Alessandro¹

2022

BJSTR

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BackgroundSince 1926, Jaffe used the term lipoblastoma to describe a tumor of immature fat cells located in the groin area [1]. Thirty two years later, Vellios et al. [2] described an "unusual tumor resembling fetal adipose tissue located in anterior wall of the thorax in an 8-monthold-child"; since it differed from hibernoma and other tumors of adult adipose tissue clinically, grossly and microscopically named this as lipoblastomatosis. Chung and Enziger used benign lipoblastoma for circumscribed types and benign lipoblastomatosis for diffuse multicentric type of these tumors [3]. Children Neck lipoblastoma is an unfrequent diagnosis, if we stand beside a toddler with a mass in his neck our first diagnosis is lymphangioma.

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“…Корректная и своевременная первичная и дифференциальная диагностика внеорганных СМТ в области шеи является критически важным фактором, который определяет оптимальный выбор тактики лечения и существенно влияет на прогноз заболевания. Сложности дифференциальной диагностики заключаются в высокой гетерогенности нозологий, отсутствии специфической клинической презентации, лабораторных и рентгенологических характеристик, что требует гистологической и иммуногистохимической верификации [13,14]. Хирургическое лечение СМТ внеорганной шейной локализации, как правило, сопряжено с высоким риском развития интра-и послеоперационных осложнений и носит отсроченный характер, требуя проведения неоадъювантной терапии, за исключением случаев, когда возможно инициально радикальное удаление опухоли.…”

Section: анализ эффективности дифференциальной диагностики и хирургич...unclassified

An analysis of the effectiveness of differential diagnosis and surgical treatment of neck soft-tissue sarcomas in children

Polev,

Grachev,

Vorozhtsov

et al. 2023

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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We conducted a retrospective sample study with prospective collection of follow-up data. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. In the time period from January 2013 to August 2020 (92 months), 126 patients with head and neck soft-tissue sarcomas (STS) received treatment at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. We included 25 patients who had undergone surgery for neck STS and divided them into 4 groups (rhabdomyosarcoma (RMS), non-RMS-like STS, RMS-like STS, IRS-IV STS – with distant metastasis at baseline). The median age at the time of correct diagnosis was 2.6 (0.5; 5.0). The median time from symptom onset to the verification of the correct pathomorphological diagnosis was 3.2 (1.6; 4.9) months. We discovered a significant number (13/25, 52%) of cases of biopsy that was performed improperly (excessive/non-diagnostic biopsy, fine-needle aspiration biopsy) at a general inpatient facility. The correct pathomorphological diagnosis was clinically and statistically much more often made at a reference center (20/25, 80%; p = 0.003). Moreover, more than half of pathomorphological diagnoses (8/13, 62%) made at a general inpatient facility were later changed at a reference center. Radical resection was achieved in 17/20 (85%) survivors. In 3/20 (15%) cases, a repeat surgery was not needed because of the patients' complete response to protocol-based treatment. Radiotherapy was carried out in 11/25 (44%) cases. Protocol-based treatment was completed in 19/25 (76%) patients, 18/25 (72%) patients achieved complete response, 2/25 (8%) patients were considered incurable, and 4/25 (16%) children died before the completion of therapy. Post-operative complications of varying severity were observed in 10/25 (40%) cases and were dependent on the degree of STS extension and the severity of the condition of the patients undergoing intensive protocol-based treatment. The median time of patient observation since diagnosis verification was 33.2 (15.6; 74.2) months. The five-year overall survival (OS) was 76.3% (95% confidence interval (CI) 51.8; 89.5), the five-year event-free survival without local disease progression – 73.9% (95% CI 41.8–90.1). Even though there weren't many patients with IRS-IV in our study (4/25, 16%), their exclusion from the analysis resulted in a higher 5-year OS rate: 88.2% (95% CI 60.2; 96.9). This study revealed significant problems in the differential diagnosis of neck STSs in children. In most patients receiving optimal protocol-based treatment, neck tumors can be radically removed at a specialized healthcare facility without mutilating surgery, which results in high 5-year OS and event-free survival rates in patients without distant metastasis. Our findings require further investigation in a larger sample of patients.

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Soft Tissue Special Issue: Imaging of Bone and Soft Tissue Sarcomas in the Head and Neck

Cited by 8 publications

References 38 publications

Giant Soft Tissue Sarcoma of Scalp with Skull and Cerebral Invasion

Giant Soft Tissue Sarcoma of Scalp with Skull and Cerebral Invasion

"Neck Lipoblastoma. Differential Diagnosis of Cervical Mass in Children"

An analysis of the effectiveness of differential diagnosis and surgical treatment of neck soft-tissue sarcomas in children

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