Soft Tissue Sarcomas

Abstract

One hundred fifty-five adult patients with "operable" soft part sarcomas including rhabdomyosarcoma, liposarcoma, leiomyosarcoma and fibrosarcoma of the trunk and extremities are reviewed. Local recurrences of 93% and 60% occurred after local and wide excisions of the primary tumor. In this series of patients, amputation was the most efficient procedure for controlling the primary site. The absolute 5 and 10-year survival rates for all groups of tumors were 50% and 26%. Development of a second primary tumor of a different cell type occurred in 9% of the patients. Local recurrence, single distant metastasis, and/or second primary tumors should be considered potentially curable and appropriate surgical and/or radiation therapy carried out.

Prognostic factors for survival in soft tissue sarcoma

“…There have been many reports on the role of surgical excision alone or followed by adjuvant radiotherapy (Abbas et al, 1981;Coe et al, 1981;Dewar & Duncan, 1985;Markhede et al, 1982;Ueda et al, 1988). A poor survival in patients with unresectable tumours, irrespective of further treatment has been shown by Suit et al (1985) and Gerner et al (1975). Various methods of surgical treatment seem to relate to different rates of local recurrence (Markhede et al, 1982;Shieber et al, 1961;Shiu et al, 1975); this may be simply a reflection of the inadequacy of surgical excision (Abbas et al, 1981;Bell et al, 1989;Collin et al, 1987;Mandard et al, 1989).…”

The Surgical Treatment and Outcome of Soft-Tissue Sarcoma

“…Our institute is a referral center and this is reflected in the biased population of patients treated ( (18), fibrohistiocytoma (nine), and malignant schwannoma (eight). Also encountered were hemangiopericytoma (seven patients), lymphangiosarcoma (six), extraosseous osteosarcoma (four), extraosseous chondrosarcoma (three), malignant mesenchymoma (three), alveolar cell sarcoma (three), epithelioid sarcoma (one), and undetermined (eight).…”

Prospective cohort study of neoadjuvant treatment in conservative surgery of soft tissue sarcomas

“…Historically, simple surgical excision of soft tissue sarcomas has provided only 40% local control with wide excision and less than 10% control with local excision (1). The addition of radiotherapy to surgery has reduced local recurrence rates to an average of 10% to 15% (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”