Soft-tissue Sarcoma of the Hand: Patient Characteristics, Treatment, and Oncologic Outcomes

Abstract

Introduction: The aim of this study was to describe patient characteristics, treatment, and oncologic outcomes of soft-tissue sarcomas (STSs) of the hand. Methods: Sixty-nine STSs of the hand in adult patients treated at a tertiary referral center were retrospectively included. We describe patient and tumor characteristics along with oncologic outcomes. Results: Epithelioid sarcoma (23%) was the most common histologic subtype, followed by synovial sarcoma (15%). Of all tumors, 17 (25%) were grade I, 22 (32%) were grade II, and 30 (44%) were grade III. The 5-year disease-free survival for epithelioid sarcomas was 75% with a disease survival of 100%, along with a metastatic rate of 15%. Of the patients with a synovial sarcoma, 40% developed metastases, and the 5-year disease-free survival was 68% and the 5-year disease survival was 73%. Conclusion: Hand STSs are aggressive tumors with a high metastatic potential. Even with adequate oncologic treatment, long-term clinical follow-up (10 years) in these tumors is advised. The treating surgical oncologist should not be deceived by their smaller size.

Prognostic factors, disparity, and equity variables impacting prognosis in bone sarcomas of the hand: SEER database review

“…This is the first investigation to report incidence and prognostic factors governing the outcomes in osseous sarcomas of the hand and wrist. Traditionally a value of less than 0.1% has been quoted as the incidence of hand malignancies 1,29 . This is the first report of a population‐based estimate of the incidence of osseous sarcomas of hand and wrist (0.017 cases per 100 000 persons, Figure 1A) as well as the age‐adjusted incidence showing peak incidence in the sixth decade of life (Figure 1B).…”

A Case of Undifferentiated Pleomorphic Sarcoma

“…Clinical suspicion for soft-tissue malignancy of the hand is usually low because most tumors are small and benign [ 4 ]. However, soft-tissue sarcomas of the hand can rapidly enlarge tumors with a high metastatic potential [ 5 ]. Clinicians should be aware of specific malignant features of soft-tissue sarcomas, such as size greater than three cm, pain, rapid growth, and subfascial location [ 5 ], to expedite proper workup and management.…”

“…However, soft-tissue sarcomas of the hand can rapidly enlarge tumors with a high metastatic potential [ 5 ]. Clinicians should be aware of specific malignant features of soft-tissue sarcomas, such as size greater than three cm, pain, rapid growth, and subfascial location [ 5 ], to expedite proper workup and management. Because of the rarity of malignant tumors of the hand, data on the oncologic outcomes of these tumors remains sparse.…”

“…Because of the rarity of malignant tumors of the hand, data on the oncologic outcomes of these tumors remains sparse. Predictions on how these tumors behave and their ultimate outcomes are generally derived from investigations of tumors of the upper extremities [ 5 ].…”

“…UPSs have no specific line of differentiation and are usually a diagnosis of exclusion [ 1 ]. Patients with undifferentiated pleomorphic sarcomas are typically older compared to patients who present with other soft tissue sarcomas [ 5 ]. UPSs are frequently found in the limbs, followed by the trunk [ 1 ].…”