Soft Tissue Sarcoma

Abstract

Sarcomas constitute a heterogeneous group of rare solid tumors of mesenchymal cell origin with distinct clinical and pathological features, and are usually divided into 2 broad categories: sarcomas of soft tissues (including fat, muscle, nerve and nerve sheath, blood vessels, and other connective tissues) and sarcomas of bone. Soft tissue sarcomas (STS) are the most frequent sarcomas; the annual incidence in the United States for 2009 is estimated to be approximately 10,660 cases, with an overall mortality rate of approximately 3820 cases per year, including adults and children. 1 The true incidence of sarcoma is underestimated, especially because a large proportion of patients with gastrointestinal stromal tumors (GIST) may not The NCCN

Myxoid liposarcoma of the hand – A rare entity

“…Otherwise, definitive radiotherapy is recommended. 9 In the reported case, excisional biopsy without adjuvant treatment was done on first surgery. After tumoral recurrence, an adjuvant radiotherapy followed excisional surgery with a tumor-free follow-up period of 5 years.…”

Multidisciplinary Retroperitoneal and Pelvic Soft-Tissue Sarcoma Case Conferences: The Added Value that Radiologists Can Provide

“…For disseminated metastatic disease, supportive care might be considered 9 . Palliative surgery is often unsuccessful and is not recommended 4,6 .…”

“…Specifically, radiologists help to determine if vital organs are invaded by tumour and cannot be resected. To ensure negative margins, en bloc resection with adjacent structures or organs (and thus multi-visceral resections) are often required 9 . Imaging helps to define involved margins and structure boundaries to help decide which adjacent tissues might need to be resected together with the tumour.…”

“…The coaxial biopsy system is the standard ct-guided biopsy technique for consistent selection of the peripheral exophytic component [ Figure 1(B)] to improve diagnostic yield and limit injury to the ivc vessel wall. Radiology often uses a coaxial biopsy technique to significantly lower the risk for seeding 9,10 . The biopsy plan and approach were documented using the sarcoma planner, and at the mcc, the pathologist confirmed the diagnosis of an ivc leiomyosarcoma.…”

Surgical Treatment of Gastrointestinal Stromal Tumors (GISTs)

“…The revision of most important published series shows that several authors refer to complete macroscopic resection (Ng, Pollock et al 1992;Crosby, Catton et al 2001;Pierie, Choudry et al 2001;Eisenberg and Judson 2004;Boni, Benevento et al 2005;Wu, Lee et al 2006) of the tumors, whereas others specify R0 resection (Connolly, Gaffney et al 2003;Langer, Gunawan et al 2003;Wu, Langerman et al 2003;Aparicio, Boige et al 2004;Heinrich and Corless 2005;Bucher, Egger et al 2006;Wardelmann, Buttner et al 2007) as the standard procedure for the surgical treatment of GISTs. Some authors sustain that the microscopic status of the surgical margins (positive or negative), in contrast to the results obtained with other malignant solid tumors, does not influences the survival of patients, or even the recurrence of GISTs (DeMatteo, Lewis et al 2000;Pierie, Choudry et al 2001;Demetri, Baker et al 2007). In a study of 200 patients with GIST, DeMatteo et al (DeMatteo, Lewis et al 2000) report that the microscopic margins do not significantly influence the evolution of the tumors and that recurrence occur most probably due to the intrinsic characteristics of the tumors.…”