Soft tissue Rosai-Dorfman disease: 29 new lesions in 18 patients, with detection of polyomavirus antigen in 3 abdominal cases

Al-Daraji, Wael I.; Anandan, A.; Klassen-Fischer, Mary; Auerbach, Aaron; Marwaha, Jayson S.; Fanburg‐Smith, Julie C.

doi:10.1016/j.anndiagpath.2010.05.006

Cited by 39 publications

(37 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two large case series of STRDD have been reported from the USA; the first described 17 cases of STRDD, of which four presented with lymphadenopathy, whereas the second found that only one of 18 patients with STRDD had associated lymph node involvement from a single node. 5,11 In both series, STRDD was more common in the trunk and proximal extremities and tended to grow rapidly, although the actual size of the lesion varied. The age of the affected patients also ranged widely and there was a slight female predominance.…”

Section: Discussionmentioning

confidence: 99%

“…11,12 The rate of recurrence of STRDD after excision has been reported to range from 21.4-54%. 5,11 Immunohistochemistry is key to differentiating soft tissue lesions in order to determine the correct diagnosis. Morphologically, STRDD is similar to nodal RDD in exhibiting the diffuse subcutaneous infiltration of large polygonal histiocytes, which in turn demonstrate emperipolesis predominantly of lymphocytes, although sometimes plasma cells, erythrocytes and neutrophils are also affected.…”

Section: Discussionmentioning

confidence: 99%

“…The age of the affected patients also ranged widely and there was a slight female predominance. 5,11 Multifocal STRDD is extremely uncommon but recurs more frequently than a solitary lesion. 11,12 The rate of recurrence of STRDD after excision has been reported to range from 21.4-54%.…”

Section: Discussionmentioning

confidence: 99%

“…5,11 Multifocal STRDD is extremely uncommon but recurs more frequently than a solitary lesion. 11,12 The rate of recurrence of STRDD after excision has been reported to range from 21.4-54%. 5,11 Immunohistochemistry is key to differentiating soft tissue lesions in order to determine the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…This reported frequent spindling of the histiocytes, others have claimed this is uncommon. 5,11 In cases with histiocyte spindling, STRDD may be confused with a sarcoma. 10 In terms of immunohistochemistry, RDD histiocytes are consistently positive for S100 proteins and CD68 and negative for CD1a.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Soft Tissue Rosai-Dorfman Disease: Case report

Rajib

Pillai

Sulaiman

et al. 2018

Sultan Qaboos Univ Med J

View full text Add to dashboard Cite

Rosai-Dorfman disease (RDD) is a rare benign proliferative histiocytic disorder characterised by massive lymphadenopathy. While extranodal involvement can occur in generalised RDD, isolated soft tissue RDD (STRDD) is extremely rare. We report a 17-year-old male patient who presented to the maxillofacial outpatient department of the Sultan Qaboos Hospital, Salalah, Oman, in 2015 with a painless cheek mass which had been slowly growing over the previous two months. Routine histopathological examinations and immunohistochemistry confirmed a diagnosis of STRDD. Currently, surgical excision is considered to be the most effective curative treatment for STRDD, as the outcomes of other treatment modalities are still unknown. Despite its rarity, STRDD should be considered in the differential diagnosis of histiocytic soft tissue lesions.

show abstract

Section: Discussionmentioning

confidence: 99%