Comparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in ratsComparison between textured silicone implants and those bonded with expanded polytetrafluoroethylene in rats
ABSTRACT
Purpose:Comparison of the inflammatory reaction promoted by textured silicone implants and that caused by the implant bonded with e-ptfe. Methods: One-hundred and fifty rats were divided into three equal groups (control, silicone, and bonded e-ptfe). These groups were subdivided into five groups, according to the second operation, i.e., 7,30,60,90 and 180 days. Histology of the peri-implant tissue was analyzed by morphometry with blood count (neutrophilos, lymphocytes, macrophages, fibroblasts and capillaries). Results: Comparison of subgroups 7,30,60,90, 180 days: -neutrophils: silicone: > in subgroup 7 days; bonded e-ptfe: > in subgroups 7 and 30 days; -lymphocytes: silicone: > in subgroup 7 and 180 days; bonded e-ptfe: > in subgroup 180 days; -macrophages: silicone: > in subgroup 7 and 60 days; bonded e-ptfe: > in subgroup 7,30 and 60 days; -fibroblasts: silicone: > in subgroup 30 and 60 days;-vascular volume: silicone: in subgroup 7, 60 and 90 days; bonded e-ptfe: > in subgroup 7 days. Comparison of groups: neutrophils : 7 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe; -lymphocytes:-7,30,90 and 180 days: in the control; macrophages:-7,30 and 60 days: > in silicone & bonded e-ptfe; 180 days > in silicone; fibroblasts: -7,30 and 90 days: > in silicone and bonded e-ptfe; 180 days: > in bonded e-ptfe; vascular volume -7,60,90 and 180 days: > in silicone and bonded e-ptfe; 30 days: > in bonded e-ptfe. Conclusions: The acute stage of the inflammatory response was more severe and irregular in the silicone implant; both the silicone implant and the silicone bonded with e-ptfe promoted chronic inflammatory reaction and weak foreign body inflammatory response. These reactions were greater in the silicone implant group. Key words: Silicone Elastomers. Silicone Gels. Polytetrafluoroethylene. Rats, Wistar.
RESUMO Objetivo:Comparar a reação inflamatória provocada pelo implante de silicone texturizado, com aquela causada por este recoberto com PTFE-E. Métodos: Foram utilizadas 150 ratas, divididos em três grupos igruais (controle, silicone e recoberto PTFE-E). Os grupos foram subdivididos em cinco subgrupos, ou seja, 7, 30, 60, 90 e 180 dias, de acordo com a data do segundo ato operatório. O tecido perimplante foi analisado histologicamente, por meio de técnica morfométrica, com contagem de neutrófilos, linfócitos, macrófagos, fibroblastos e capilares. Resultados: Comparação dos subgrupos 7, 30, 60, 90 180 dias: -neutrófilos -silicone: > no subgrupo 7 dias; rec-ptfe: > nos subgrupos 7 e 30 dias; -linfócitos: silicone: > no subgrupo 7 e 180 dias; rec-ptfe: > no subgrupo 180 dias; -macrófagos: silicone: > no subgrupo 7 e 60 dias; rec-ptfe: > no subgrupo 7, 30 e 60 dias; -fibroblastos: silicone: > no subgrupo 30 e 60 dias; -volume vascular: silicone: > no subrupo 7, 60 e 90 dias; re...