Soft Tissue Reconstruction with Artelon for Multiple Foot and Ankle Applications

Petranto, Russell D; Lubin, Megan; Floros, Robert C.; Pfeiffer, Darelle; Spiess, Kerianne E.; Lenz, Robin; Crowell, Amanda; Ahmad, Haseeb; Chandrani, Sameep; Landsman, Adam

doi:10.1016/j.cpm.2018.02.008

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…It is also hyperelastic to permit loading and stimulation of the tissues during late remodeling. 12,10,18 Furthermore, PUUR is inert and thus incorporates with native tissue without any immune response. In addition, it integrates into the repair site without necrosis or foreign body reaction, maintains its strength for 4 to 6 years, and is eliminated benignly through hydrolytic degradation.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Insertional Achilles Tendinosis With Polyurethane Urea–Based Matrix Augmentation

Cuttica

Neufeld

Baird

et al. 2022

Foot & Ankle Specialist

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Introduction Surgical treatment for insertional Achilles tendinosis (IAT) sometimes requires tendon repair augmentation. The purpose of this study is to evaluate the efficacy of polycaprolactone-based polyurethane urea (PUUR) matrix augmentation in the treatment of IAT. Methods A retrospective review was performed in surgically treated IAT. Repairs were augmented with a PUUR matrix. Factors evaluated included date of full weightbearing, patient satisfaction, Visual Analog Scale (VAS) pain score, strength, and ankle motion. The Wilcoxon signed-rank test was used to compare baseline and final follow-up VAS scores. Results A total of 18 cases were included in the study. The mean patient age was 54.61 ± 8.25 (40-75) years with a mean follow-up of 163.61 ± 57.81 (92-314) days. Patient satisfaction was obtained on 15 of 18 patients, with 14 patients satisfied with their outcome. Mean VAS for pain significantly decreased from 6.19 ± 1.97 (2.5-9) to 0.83 ± 1.54 (0-5) postoperatively, which was statistically significant (P < .01). Conclusion Achilles tendon augmentation with the PUUR matrix is a viable option in the treatment of IAT. Its use in this condition has minimal morbidity and can be an alternative to other forms of augmentation. Levels of Evidence: Level IV: Retrospective case series

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Section: Discussionmentioning

confidence: 99%

Treatment of Insertional Achilles Tendinosis With Polyurethane Urea–Based Matrix Augmentation

Cuttica

Neufeld

Baird

et al. 2022

Foot & Ankle Specialist

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“…Receiving a CE Mark in Europe and clearance from the U.S. Food and Drug Administration (FDA) for these procedures, it has been applied clinically in cases of anterior cruciate ligament (ACL) reconstruction, 50 Achilles tendon repair, 51 rotator cuff repair, 52,53 and a variety of foot/ankle repair procedures. 54 Artelon ® is synthesized from a soft segment of PCL, a hard segment of 4,4 0 -diphenylmethane diisocyanate (MDI) and a chain extender of 1,3-diaminopropane. The PU is fabricated into strands of fiber via wet spinning that are then woven into a mesh sheet 55 (Figure 1B).…”

Section: Artelon ® Dynamic Matrix™ (Artelon)mentioning

confidence: 99%

“…Artelon® Dynamic Matrix is a PCL‐based PU that is clinically indicated for surgical repair of tendons and ligaments (Figure 1). Receiving a CE Mark in Europe and clearance from the U.S. Food and Drug Administration (FDA) for these procedures, it has been applied clinically in cases of anterior cruciate ligament (ACL) reconstruction, 50 Achilles tendon repair, 51 rotator cuff repair, 52,53 and a variety of foot/ankle repair procedures 54 . Artelon® is synthesized from a soft segment of PCL, a hard segment of 4,4′‐diphenylmethane diisocyanate (MDI) and a chain extender of 1,3‐diaminopropane.…”

Section: Clinical Applications Of Biodegradable Pu Scaffoldsmentioning

confidence: 99%

“…Focusing on subscapularis tendon repair, Petriccioli et al followed 10 patients over 23 months and found one instance of retearing and no infection or rejection of the graft. Marberry et al 54 used Artelon® patch material on two‐tendon tears of the supraspinatus and infraspinatus tendons in 17 patients. One patient required follow‐up surgery at 8 months due to a re‐tear, but the remaining 16 reported significant improvement in quality of life and range of motion at 12 months follow‐up.…”

Section: Clinical Applications Of Biodegradable Pu Scaffoldsmentioning

confidence: 99%

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Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

Pedersen

Kim

Wagner

2022

J Biomedical Materials Res

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Early explorations of tissue engineering and regenerative medicine concepts commonly utilized simple polyesters such as polyglycolide, polylactide, and their copolymers as scaffolds. These biomaterials were deemed clinically acceptable, readily accessible, and provided processability and a generally known biological response. With experience and refinement of approaches, greater control of material properties and integrated bioactivity has received emphasis and a broadened palette of synthetic biomaterials has been employed. Biodegradable polyurethanes (PUs) have emerged as an attractive option for synthetic scaffolds in a variety of tissue applications because of their flexibility in molecular design and ability to fulfill mechanical property objectives, particularly in soft tissue applications. Biodegradable PUs are highly customizable based on their composition and processability to impart tailored mechanical and degradation behavior. Additionally, bioactive agents can be readily incorporated into these scaffolds to drive a desired biological response. Enthusiasm for biodegradable PU scaffolds has soared in recent years, leading to rapid growth in the literature documenting novel PU chemistries, scaffold designs, mechanical properties, and aspects of biocompatibility. Despite the enthusiasm in the field, there are still few examples of biodegradable PU scaffolds that have achieved regulatory approval and routine clinical use. However, there is a growing literature where biodegradable PU scaffolds are being specifically developed for a wide range of pathologies and where relevant pre‐clinical models are being employed. The purpose of this review is first to highlight examples of clinically used biodegradable PU scaffolds, and then to summarize the growing body of reports on pre‐clinical applications of biodegradable PU scaffolds.

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“…Autografts are taken from one part of the body, increasing the risk of disease at the donor site and making their use inefficient. Using allografts and xenografts to reduce donor site morbidity raises the concern of immune rejection and disease transmission ( Petranto et al, 2018 ; Schneider et al, 2018 ; Li et al, 2021a ; Regennass et al, 2021 ). As a result, the repaired tendon has weak biochemical and mechanical properties and is prone to re-injury.…”

Section: Introductionmentioning

confidence: 99%

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

Zhu

He²,

Ji³

et al. 2022

Front. Bioeng. Biotechnol.

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The Achilles tendon (AT) is responsible for running, jumping, and standing. The AT injuries are very common in the population. In the adult population (21–60 years), the incidence of AT injuries is approximately 2.35 per 1,000 people. It negatively impacts people’s quality of life and increases the medical burden. Due to its low cellularity and vascular deficiency, AT has a poor healing ability. Therefore, AT injury healing has attracted a lot of attention from researchers. Current AT injury treatment options cannot effectively restore the mechanical structure and function of AT, which promotes the development of AT regenerative tissue engineering. Various nanofiber-based scaffolds are currently being explored due to their structural similarity to natural tendon and their ability to promote tissue regeneration. This review discusses current methods of AT regeneration, recent advances in the fabrication and enhancement of nanofiber-based scaffolds, and the development and use of multiscale nanofiber-based scaffolds for AT regeneration.

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Soft Tissue Reconstruction with Artelon for Multiple Foot and Ankle Applications

Cited by 12 publications

References 24 publications

Treatment of Insertional Achilles Tendinosis With Polyurethane Urea–Based Matrix Augmentation

Treatment of Insertional Achilles Tendinosis With Polyurethane Urea–Based Matrix Augmentation

Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

Advanced Nanofiber-Based Scaffolds for Achilles Tendon Regenerative Engineering

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