Soft tissue oncocytoma

Polk, Peggy; Parker, Kim M.; Biggs, Paul J.

doi:10.1016/s0046-8177(96)90378-0

Cited by 10 publications

(8 citation statements)

References 2 publications

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“…Rare oncocytic tumours have also been described in the breast [22] and in the prostate gland [8]. Recent reports, all including the results of ultrastructural examination, have documented the occurrence of oncocytic neoplasms in the skin [75], soft tissues [67], the haematolymphoid system [12] and the meninges [72]. The oncocytic variant of meningioma has been associated with a relatively aggressive behaviour [72].…”

Section: Pathological and Clinical Featuresmentioning

confidence: 99%

Oncocytic tumours

Tallini¹

1998

Virchows Archiv

145

131

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Oncocytic tumours represent a distinctive set of lesions with distinctive granular cytoplasmic eosinophilia of the neoplastic cells. These cells are called oncocytes because of the "swollen" appearance they have as the result of a striking accumulation of mitochondria. Although generally uncommon, oncocytic tumours are by no means rare and have been reported, with different frequencies, in virtually every organ. A variety of biochemical and molecular changes have been identified, and the aberrant biogenesis of mitochondria in oncocytic cells bears intriguing similarities to that of a group of degenerative disorders known as mitochondrial encephalomyopathies. Although the relationship between the accumulation of mitochondria and the occurrence of tumours is unknown, investigation into the cellular alterations of oncocytes may further our knowledge of a variety of important biological processes such as proliferation, energy production and ageing.

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Section: Pathological and Clinical Featuresmentioning

confidence: 99%

Oncocytic tumours

Tallini¹

1998

Virchows Archiv

145

131

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“…The proposal by Ghadially [7] of 60% of the total cytoplasmic volume loaded by mitochondria has become the generally accepted cutoff value for the designation of oncocyte. Even thought oncocytic tumors may occur in several different anatomical sites such as meninges [8], choroid plexus [9], soft tissue [10], and gastrointestinal tract [11], they tend more frequently to affect endocrine organs and glandular epithelia such as thyroid, salivary glands, and renal tubules [12] that have high metabolic activity. In the definition of oncocytoma, the proportion of neoplastic cells exhibiting oncocytic features varies in different organs, being 70% in breast [13], 75% in thyroid neoplasm [14,15], and 100% in renal tumors [16].…”

Section: Introductionmentioning

confidence: 99%

Oncocytic carcinoma of the breast: frequency, morphology and follow-up

et al. 2011

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“…[4][5][6] Tumours containing oncocytes can also occur rarely in other sites such as the ovary, 7 8 lung, 6 9 10 breast, 11 skin 12 and soft tissue. 13 Although several tumours with prominent ''pink'' (eosinophilic) cytoplasm are recognisable in the digestive tract, tumours with oncocytic features rarely affect the gastrointestinal tract, liver and pancreas. 14 Adenocarcinomas with oncocytic features have also been encountered in the stomach [15][16][17] and in the small intestine.…”

mentioning

confidence: 99%

Rectal adenocarcinoma with oncocytic features: possible relationship with preoperative chemoradiotherapy

2006

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Background: The introduction of preoperative chemoradiation into the treatment protocol of rectal adenocarcinomas has affected the microscopical morphology in subsequent resection specimens. The constellation of histopathological changes is varied and well documented. Aim: To describe oncocytic change in rectal cancers that have been treated with chemoradiation before surgery. Methods: 7 of 54 patients with rectal cancer were identified with a history of chemoradiation, specifically directed to the rectal tumours in fractions of 4500-5000 cGy of radiation and 5-fluorouracil. The rectal tumours in five of these seven patients were composed of oncocytes that constituted 30-80% of the cancers. The patients were three men and two women aged 65-73 years, all with T3 N0 tumours. The intervals between chemoradiation and resection varied from 3 to 12 weeks. Results: The tumour cells conformed to oncocytes morphologically (large size with abundant, granular eosinophilic cytoplasm, vesicular nuclei and prominent acidophilic nucleoli), immunohistochemically (positive for carcinoembryonic antigen, cytokeratin 20 and caudal type homeo box transcription factor 2, but negative for both chromogranin and synaptophysin) and ultrastructurally (large cells showing tight junctions, cytoplasmic engorgement by mitochondria and absence of neurosecretory granules). Conclusions: The changes in these cells differ from those described previously in endocrine cells encountered in pretreated rectal cancers. Oncocytic change in this particular clinical context occurs as a reflection of cytotoxic damage or cellular hypoxia induced by chemoradiation resulting in degeneration of the cell and the oncocytic phenotype. Oncocytic change may be an under-recognised histopathological change in rectal cancers receiving preoperative chemoradiation.

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Soft tissue oncocytoma

Cited by 10 publications

References 2 publications

Oncocytic tumours

Oncocytic tumours

Oncocytic carcinoma of the breast: frequency, morphology and follow-up

Rectal adenocarcinoma with oncocytic features: possible relationship with preoperative chemoradiotherapy

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